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Bioavailability study of calcium sandoz-250 by atomic absorption spectroscopy in albino rats.

Patel BN, Krishnaveni N, Jivani NP, Khodakiya AS, Khodakiya MS, Parida SK - Ayu (2014 Oct-Dec)

Bottom Line: Linearity curve was plotted for 0.5-2.5 ppm, given R (2) value 0.9975.The C max, i.e. C max after administration of calcium sandoz-250 was 0.793 mg/ml at 90 min (T max).Measurable calcium-blood levels were noticed in all subjects up to 3.0 h after administration of calcium sandoz-250.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Analysis, C.U. Shah College of Pharmacy and Research, Wadhwan, Gujarat, India.

ABSTRACT

Background: Calcium sandoz-250 is an Ayurvedic calcium supplement, containing Khatika Churna. Bioavailability study of the formulation is essential for estimation of peak plasma concentration (C max), time to C max and rate of absorption.

Aim: To evaluate the absorption parameters of calcium sandoz-250 in albino rats by atomic absorption spectroscopic (AAS) method.

Materials and methods: Study was carried out as a single dose, open-label, randomized study. Estimation of calcium was carried out by AAS, after validating the method for a few parameters for the estimation. Pharmacokinetic parameters such as C max, time to peak concentration (T max), area under the plasma concentration - time curve were calculated for calcium on administration of calcium sandoz-250.

Results: Linearity curve was plotted for 0.5-2.5 ppm, given R (2) value 0.9975. The C max, i.e. C max after administration of calcium sandoz-250 was 0.793 mg/ml at 90 min (T max). Measurable calcium-blood levels were noticed in all subjects up to 3.0 h after administration of calcium sandoz-250.

Conclusion: Calcium sandoz-250, consisting of Khatika Churna, increases the blood calcium level in albino rats.

No MeSH data available.


Related in: MedlinePlus

Mean plasma concentration of calcium from animals (administered calcium sandoz-250)
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Figure 3: Mean plasma concentration of calcium from animals (administered calcium sandoz-250)

Mentions: Figure 3 shows bioavailability curve of the calcium after oral administration of calcium sandoz-250. A summary of different pharmacokinetic parameters was depicted in Table 6.


Bioavailability study of calcium sandoz-250 by atomic absorption spectroscopy in albino rats.

Patel BN, Krishnaveni N, Jivani NP, Khodakiya AS, Khodakiya MS, Parida SK - Ayu (2014 Oct-Dec)

Mean plasma concentration of calcium from animals (administered calcium sandoz-250)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492031&req=5

Figure 3: Mean plasma concentration of calcium from animals (administered calcium sandoz-250)
Mentions: Figure 3 shows bioavailability curve of the calcium after oral administration of calcium sandoz-250. A summary of different pharmacokinetic parameters was depicted in Table 6.

Bottom Line: Linearity curve was plotted for 0.5-2.5 ppm, given R (2) value 0.9975.The C max, i.e. C max after administration of calcium sandoz-250 was 0.793 mg/ml at 90 min (T max).Measurable calcium-blood levels were noticed in all subjects up to 3.0 h after administration of calcium sandoz-250.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Analysis, C.U. Shah College of Pharmacy and Research, Wadhwan, Gujarat, India.

ABSTRACT

Background: Calcium sandoz-250 is an Ayurvedic calcium supplement, containing Khatika Churna. Bioavailability study of the formulation is essential for estimation of peak plasma concentration (C max), time to C max and rate of absorption.

Aim: To evaluate the absorption parameters of calcium sandoz-250 in albino rats by atomic absorption spectroscopic (AAS) method.

Materials and methods: Study was carried out as a single dose, open-label, randomized study. Estimation of calcium was carried out by AAS, after validating the method for a few parameters for the estimation. Pharmacokinetic parameters such as C max, time to peak concentration (T max), area under the plasma concentration - time curve were calculated for calcium on administration of calcium sandoz-250.

Results: Linearity curve was plotted for 0.5-2.5 ppm, given R (2) value 0.9975. The C max, i.e. C max after administration of calcium sandoz-250 was 0.793 mg/ml at 90 min (T max). Measurable calcium-blood levels were noticed in all subjects up to 3.0 h after administration of calcium sandoz-250.

Conclusion: Calcium sandoz-250, consisting of Khatika Churna, increases the blood calcium level in albino rats.

No MeSH data available.


Related in: MedlinePlus