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Standard manufacturing procedure of Shadguna Balijarita Makaradhwaja.

Khedekar SB, Prajapati PK - Ayu (2014 Oct-Dec)

Bottom Line: Total four batches of SBM were prepared by using electrical muffle furnace (EMF).All the involved procedures were followed as per classical guidelines.Average 13.68% yield of SBM was observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Rasashastra and Bhaishajya Kalpana, Shree Saptashrungi Ayurveda Mahavidyalaya, Nashik, Maharashtra, India.

ABSTRACT

Background: Makaradhwaja is one of the most potent herbomineral medicines of Ayurveda. Different references for the preparation of Makaradhwaja were reported in classics. According to the proportion of sulfur (Gandhaka), three references were mentioned in classics that is, Dwiguna (2:1 = S: Hg), Triguna (3:1 = S: Hg) and Shadguna (6:1 = S: Hg). Makaradhwaja is prepared by Kupipakwa system of heating. In the preparation of Kupipakwa medicine as the ratio of sulfur to mercury increases it becomes difficult to prepare medicine.

Aim: To standardize manufacturing procedure of Shadguna Balijarita Makaradhwaja (SBM).

Materials and methods: Total four batches of SBM were prepared by using electrical muffle furnace (EMF). All the involved procedures were followed as per classical guidelines.

Results: Average 13.68% yield of SBM was observed.

Conclusion: SBM requires intermittent heating pattern, that is, mild heat (100-125° C) for 2.5 hrs, moderate heat (250-450° C) for 4.5 hrs and strong heat (450-600° C) for 5 hrs for 290.5 g Kajjali.

No MeSH data available.


Related in: MedlinePlus

Sublimed product collected from the neck of glass bottle
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Figure 8: Sublimed product collected from the neck of glass bottle

Mentions: A glass bottle (of 750 ml capacity) was wrapped with mud smeared cotton cloth. Total seven consecutive layers were wrapped after complete drying of earlier layer. Kajjali was filled in this glass bottle, placed in electrical muffle furnace [Figure 6] and heat was given in gradual increasing manner. Heat was gradually increased as per schedule that is mild heat (Mriduagni) at 100-250°C for 2.5 h, moderate heat (Madhyamagni) at 250-450°C for 4.5 h and strong heat (Tivragni) at 450-600°C for 5 h [Graph 1]. During the course of heating, red hot iron rod (Agni Tapta Shalaka) was repeatedly inserted into the neck of glass bottle to remove settled sulfur. After achieving the confirmative tests, the mouth of glass bottle was sealed with cork (iron nut wrapped with cotton cloth and smeared with mud). Temperature was increased up to 600°C and maintained for next 2 h. After this, furnace was switched off and left for self-cooling. Next day morning, glass bottle was taken out from the furnace. The bottle was scraped to remove the burnt layers of cotton cloth followed by cleaning. Thread soaked in kerosene was tied on the bottle and thread was ignited. Thread was removed after complete burning and few drops of water was sprinkled over it, due to which, bottle was broken in two parts. Makaradhwaja was collected from the neck [Figure 7], and gold ash from the bottom of the bottle. Makaradhwaja was triturated in china clay mortar and pestle up to fine red colored powder [Figure 8]. Same procedure was adopted for the rest of three samples. Total four batches were prepared to determine the standard manufacturing procedure (SMP) for SBM [Table 2].


Standard manufacturing procedure of Shadguna Balijarita Makaradhwaja.

Khedekar SB, Prajapati PK - Ayu (2014 Oct-Dec)

Sublimed product collected from the neck of glass bottle
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492029&req=5

Figure 8: Sublimed product collected from the neck of glass bottle
Mentions: A glass bottle (of 750 ml capacity) was wrapped with mud smeared cotton cloth. Total seven consecutive layers were wrapped after complete drying of earlier layer. Kajjali was filled in this glass bottle, placed in electrical muffle furnace [Figure 6] and heat was given in gradual increasing manner. Heat was gradually increased as per schedule that is mild heat (Mriduagni) at 100-250°C for 2.5 h, moderate heat (Madhyamagni) at 250-450°C for 4.5 h and strong heat (Tivragni) at 450-600°C for 5 h [Graph 1]. During the course of heating, red hot iron rod (Agni Tapta Shalaka) was repeatedly inserted into the neck of glass bottle to remove settled sulfur. After achieving the confirmative tests, the mouth of glass bottle was sealed with cork (iron nut wrapped with cotton cloth and smeared with mud). Temperature was increased up to 600°C and maintained for next 2 h. After this, furnace was switched off and left for self-cooling. Next day morning, glass bottle was taken out from the furnace. The bottle was scraped to remove the burnt layers of cotton cloth followed by cleaning. Thread soaked in kerosene was tied on the bottle and thread was ignited. Thread was removed after complete burning and few drops of water was sprinkled over it, due to which, bottle was broken in two parts. Makaradhwaja was collected from the neck [Figure 7], and gold ash from the bottom of the bottle. Makaradhwaja was triturated in china clay mortar and pestle up to fine red colored powder [Figure 8]. Same procedure was adopted for the rest of three samples. Total four batches were prepared to determine the standard manufacturing procedure (SMP) for SBM [Table 2].

Bottom Line: Total four batches of SBM were prepared by using electrical muffle furnace (EMF).All the involved procedures were followed as per classical guidelines.Average 13.68% yield of SBM was observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Rasashastra and Bhaishajya Kalpana, Shree Saptashrungi Ayurveda Mahavidyalaya, Nashik, Maharashtra, India.

ABSTRACT

Background: Makaradhwaja is one of the most potent herbomineral medicines of Ayurveda. Different references for the preparation of Makaradhwaja were reported in classics. According to the proportion of sulfur (Gandhaka), three references were mentioned in classics that is, Dwiguna (2:1 = S: Hg), Triguna (3:1 = S: Hg) and Shadguna (6:1 = S: Hg). Makaradhwaja is prepared by Kupipakwa system of heating. In the preparation of Kupipakwa medicine as the ratio of sulfur to mercury increases it becomes difficult to prepare medicine.

Aim: To standardize manufacturing procedure of Shadguna Balijarita Makaradhwaja (SBM).

Materials and methods: Total four batches of SBM were prepared by using electrical muffle furnace (EMF). All the involved procedures were followed as per classical guidelines.

Results: Average 13.68% yield of SBM was observed.

Conclusion: SBM requires intermittent heating pattern, that is, mild heat (100-125° C) for 2.5 hrs, moderate heat (250-450° C) for 4.5 hrs and strong heat (450-600° C) for 5 hrs for 290.5 g Kajjali.

No MeSH data available.


Related in: MedlinePlus