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Effect of Neem oil and Haridra on non-healing wounds.

Singh A, Singh AK, Narayan G, Singh TB, Shukla VK - Ayu (2014 Oct-Dec)

Bottom Line: To compare the effect of Neem oil and Haridra in the treatment of chronic non-healing wounds.Microscopic angiogenesis grading system scores and DNA concentration showed highly significant effect of combined use of both drugs when compared before and after results of treatment (P < 0.001).Topical use of Neem oil and oral use of Haridra powder capsule used in combination were found effective for chronic non-healing wounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Dravyaguna, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

ABSTRACT

Background: In Ayurveda, Vrana (wound) has stated as tissue destruction and discoloration of viable tissue due to various etiology. In Sushruta Samhita, Sushruta described Vrana as a main subject. Most commonly Vrana can be classified into Shuddha and Dushta Vrana (chronic wound/nonhealing ulcers). Among the various drugs mentioned for Dushta Vrana, two of them, Neem (Azadirechta indica A. Juss) oil and Haridra (Curcuma longa Linn.) powder are selected for their wide spectrum action on wound.

Aim: To compare the effect of Neem oil and Haridra in the treatment of chronic non-healing wounds.

Materials and methods: Total 60 patients of wounds with more than 6 weeks duration were enrolled and alternatively allocated to Group I (topical application of Neem oil), Group II (Haridra powder capsules, 1 g 3 times orally) and Group III (both drugs). Duration of treatment was considered until complete healing of the wound, whereas 4(th) and 8(th) week were considered for assessment of 50% healing. Wound size was measured and recorded at weekly intervals. Wound biopsy was repeated after 4 weeks for assessment of angiogenesis and deoxyribonucleic acid (DNA) analysis.

Results: After 8 weeks of treatment, 50% wound healing was observed in 43.80% patients of Group I, 18.20% patients of Group II, and 70.00% patients of Group III. Microscopic angiogenesis grading system scores and DNA concentration showed highly significant effect of combined use of both drugs when compared before and after results of treatment (P < 0.001).

Conclusion: Topical use of Neem oil and oral use of Haridra powder capsule used in combination were found effective for chronic non-healing wounds.

No MeSH data available.


Related in: MedlinePlus

Phenol chloroform method for deoxyribonucleic acid estimation in tissue
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Related In: Results  -  Collection

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Figure 1: Phenol chloroform method for deoxyribonucleic acid estimation in tissue

Mentions: DNA content estimation was done in the sample of wound tissue by phenol-chloroform method [Chart 1]. Tissue was kept in ribonucleic acid later solution at −70°C temperature for DNA assessment.[8] DNA assessment was done twice that is before treatment and after 4 weeks of scheduled treatment.


Effect of Neem oil and Haridra on non-healing wounds.

Singh A, Singh AK, Narayan G, Singh TB, Shukla VK - Ayu (2014 Oct-Dec)

Phenol chloroform method for deoxyribonucleic acid estimation in tissue
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4492024&req=5

Figure 1: Phenol chloroform method for deoxyribonucleic acid estimation in tissue
Mentions: DNA content estimation was done in the sample of wound tissue by phenol-chloroform method [Chart 1]. Tissue was kept in ribonucleic acid later solution at −70°C temperature for DNA assessment.[8] DNA assessment was done twice that is before treatment and after 4 weeks of scheduled treatment.

Bottom Line: To compare the effect of Neem oil and Haridra in the treatment of chronic non-healing wounds.Microscopic angiogenesis grading system scores and DNA concentration showed highly significant effect of combined use of both drugs when compared before and after results of treatment (P < 0.001).Topical use of Neem oil and oral use of Haridra powder capsule used in combination were found effective for chronic non-healing wounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Dravyaguna, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

ABSTRACT

Background: In Ayurveda, Vrana (wound) has stated as tissue destruction and discoloration of viable tissue due to various etiology. In Sushruta Samhita, Sushruta described Vrana as a main subject. Most commonly Vrana can be classified into Shuddha and Dushta Vrana (chronic wound/nonhealing ulcers). Among the various drugs mentioned for Dushta Vrana, two of them, Neem (Azadirechta indica A. Juss) oil and Haridra (Curcuma longa Linn.) powder are selected for their wide spectrum action on wound.

Aim: To compare the effect of Neem oil and Haridra in the treatment of chronic non-healing wounds.

Materials and methods: Total 60 patients of wounds with more than 6 weeks duration were enrolled and alternatively allocated to Group I (topical application of Neem oil), Group II (Haridra powder capsules, 1 g 3 times orally) and Group III (both drugs). Duration of treatment was considered until complete healing of the wound, whereas 4(th) and 8(th) week were considered for assessment of 50% healing. Wound size was measured and recorded at weekly intervals. Wound biopsy was repeated after 4 weeks for assessment of angiogenesis and deoxyribonucleic acid (DNA) analysis.

Results: After 8 weeks of treatment, 50% wound healing was observed in 43.80% patients of Group I, 18.20% patients of Group II, and 70.00% patients of Group III. Microscopic angiogenesis grading system scores and DNA concentration showed highly significant effect of combined use of both drugs when compared before and after results of treatment (P < 0.001).

Conclusion: Topical use of Neem oil and oral use of Haridra powder capsule used in combination were found effective for chronic non-healing wounds.

No MeSH data available.


Related in: MedlinePlus