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Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state.

Bellay T, Klaus A, Seshadri S, Plenz D - Elife (2015)

Bottom Line: As the animal transitions from the anesthetized to awake state, spontaneous single neuron firing increases in irregularity and assembles into scale-invariant avalanches at the group level.In vitro spike avalanches emerged naturally yet required balanced excitation and inhibition.This demonstrates that neuronal avalanches are linked to the global physiological state of wakefulness and that cortical resting activity organizes as avalanches from firing of local PN groups to global population activity.

View Article: PubMed Central - PubMed

Affiliation: Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, United States.

ABSTRACT
Spontaneous fluctuations in neuronal activity emerge at many spatial and temporal scales in cortex. Population measures found these fluctuations to organize as scale-invariant neuronal avalanches, suggesting cortical dynamics to be critical. Macroscopic dynamics, though, depend on physiological states and are ambiguous as to their cellular composition, spatiotemporal origin, and contributions from synaptic input or action potential (AP) output. Here, we study spontaneous firing in pyramidal neurons (PNs) from rat superficial cortical layers in vivo and in vitro using 2-photon imaging. As the animal transitions from the anesthetized to awake state, spontaneous single neuron firing increases in irregularity and assembles into scale-invariant avalanches at the group level. In vitro spike avalanches emerged naturally yet required balanced excitation and inhibition. This demonstrates that neuronal avalanches are linked to the global physiological state of wakefulness and that cortical resting activity organizes as avalanches from firing of local PN groups to global population activity.

No MeSH data available.


Related in: MedlinePlus

(A) Maximum cluster rate is observed at intermediate threshold levels for all three conditions.(B) Average cluster size distributions as a function of λthr for WK.DOI:http://dx.doi.org/10.7554/eLife.07224.011
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fig5s1: (A) Maximum cluster rate is observed at intermediate threshold levels for all three conditions.(B) Average cluster size distributions as a function of λthr for WK.DOI:http://dx.doi.org/10.7554/eLife.07224.011

Mentions: Avalanche dynamics were unique to the AW state (Figure 5). During AN, cluster size distributions at corresponding (Figure 5—figure supplement 1A) were slightly bimodal (Figure 5A, arrow), in line with a progressively worse fit to a power law for WK and AN compared to AW (Figure 5B; ANOVA, p < 0.05; cf.Figure 4, Figure 5—figure supplement 1B).10.7554/eLife.07224.010Figure 5.Avalanche dynamics is abolished under anesthesia.


Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state.

Bellay T, Klaus A, Seshadri S, Plenz D - Elife (2015)

(A) Maximum cluster rate is observed at intermediate threshold levels for all three conditions.(B) Average cluster size distributions as a function of λthr for WK.DOI:http://dx.doi.org/10.7554/eLife.07224.011
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4492006&req=5

fig5s1: (A) Maximum cluster rate is observed at intermediate threshold levels for all three conditions.(B) Average cluster size distributions as a function of λthr for WK.DOI:http://dx.doi.org/10.7554/eLife.07224.011
Mentions: Avalanche dynamics were unique to the AW state (Figure 5). During AN, cluster size distributions at corresponding (Figure 5—figure supplement 1A) were slightly bimodal (Figure 5A, arrow), in line with a progressively worse fit to a power law for WK and AN compared to AW (Figure 5B; ANOVA, p < 0.05; cf.Figure 4, Figure 5—figure supplement 1B).10.7554/eLife.07224.010Figure 5.Avalanche dynamics is abolished under anesthesia.

Bottom Line: As the animal transitions from the anesthetized to awake state, spontaneous single neuron firing increases in irregularity and assembles into scale-invariant avalanches at the group level.In vitro spike avalanches emerged naturally yet required balanced excitation and inhibition.This demonstrates that neuronal avalanches are linked to the global physiological state of wakefulness and that cortical resting activity organizes as avalanches from firing of local PN groups to global population activity.

View Article: PubMed Central - PubMed

Affiliation: Section on Critical Brain Dynamics, National Institute of Mental Health, Bethesda, United States.

ABSTRACT
Spontaneous fluctuations in neuronal activity emerge at many spatial and temporal scales in cortex. Population measures found these fluctuations to organize as scale-invariant neuronal avalanches, suggesting cortical dynamics to be critical. Macroscopic dynamics, though, depend on physiological states and are ambiguous as to their cellular composition, spatiotemporal origin, and contributions from synaptic input or action potential (AP) output. Here, we study spontaneous firing in pyramidal neurons (PNs) from rat superficial cortical layers in vivo and in vitro using 2-photon imaging. As the animal transitions from the anesthetized to awake state, spontaneous single neuron firing increases in irregularity and assembles into scale-invariant avalanches at the group level. In vitro spike avalanches emerged naturally yet required balanced excitation and inhibition. This demonstrates that neuronal avalanches are linked to the global physiological state of wakefulness and that cortical resting activity organizes as avalanches from firing of local PN groups to global population activity.

No MeSH data available.


Related in: MedlinePlus