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Development and performance analysis of Si-CaP/fine particulate bone powder combined grafts for bone regeneration.
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However, when applied individually, these two materials fall short of an ideal substitute material.Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis.Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually.
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PubMed Central - PubMed
Affiliation: Department of Orthopaedic Surgery, The Second Harbin City Hospital, Harbin, 150056, China. scl324@126.com.
ABSTRACT
Background: Although autogenous bone grafts as well as several bone graft substitute material have been used for some time, there is high demand for more efficient and less costly bone-substitute materials. Silicon-substituted calcium phosphates (Si-CaP) and fine particulate bone powder (FPBP) preparations have been previously shown to individually possess many of the required features of a bone graft substitute scaffold. However, when applied individually, these two materials fall short of an ideal substitute material. We investigated a new concept of combining Si-CaP with FPBP for improved performance in bone-repair. Methods: We assessed Si-CaP/FPBP combined grafts in vitro, by measuring changes in pH, weight loss, water absorption and compressive strength over time. Results: Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis. Conclusion: Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually. No MeSH data available. Related in: MedlinePlus |
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Fig6: H&E images of Si-CaP/FPBP at day 0 (a), 3 (b), 7 (c), 14 (d), and 28 (e) days in vitro degradation. n = 7. Mentions: H&E observation found that Si-CaP and FPBP engaged tightly with each other at the interface on day 0. As time increased, Si-CaP at the junction between Si-CaP and FPBP became sparse and loose. Lacunae gradually became empty. After 14 days of in vitro incubation, osteoblasts had lyzed and disappeared (Figure 6a–e).Figure 6 |
View Article: PubMed Central - PubMed
Affiliation: Department of Orthopaedic Surgery, The Second Harbin City Hospital, Harbin, 150056, China. scl324@126.com.
Background: Although autogenous bone grafts as well as several bone graft substitute material have been used for some time, there is high demand for more efficient and less costly bone-substitute materials. Silicon-substituted calcium phosphates (Si-CaP) and fine particulate bone powder (FPBP) preparations have been previously shown to individually possess many of the required features of a bone graft substitute scaffold. However, when applied individually, these two materials fall short of an ideal substitute material. We investigated a new concept of combining Si-CaP with FPBP for improved performance in bone-repair.
Methods: We assessed Si-CaP/FPBP combined grafts in vitro, by measuring changes in pH, weight loss, water absorption and compressive strength over time.
Results: Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis.
Conclusion: Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually.
No MeSH data available.
