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Development and performance analysis of Si-CaP/fine particulate bone powder combined grafts for bone regeneration.

Sun C, Tian Y, Xu W, Zhou C, Xie H, Wang X - Biomed Eng Online (2015)

Bottom Line: However, when applied individually, these two materials fall short of an ideal substitute material.Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis.Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, The Second Harbin City Hospital, Harbin, 150056, China. scl324@126.com.

ABSTRACT

Background: Although autogenous bone grafts as well as several bone graft substitute material have been used for some time, there is high demand for more efficient and less costly bone-substitute materials. Silicon-substituted calcium phosphates (Si-CaP) and fine particulate bone powder (FPBP) preparations have been previously shown to individually possess many of the required features of a bone graft substitute scaffold. However, when applied individually, these two materials fall short of an ideal substitute material. We investigated a new concept of combining Si-CaP with FPBP for improved performance in bone-repair.

Methods: We assessed Si-CaP/FPBP combined grafts in vitro, by measuring changes in pH, weight loss, water absorption and compressive strength over time.

Results: Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis.

Conclusion: Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually.

No MeSH data available.


Related in: MedlinePlus

SEM images of Si-CaP/FPBP at day 0 (a), 3 (b), 7 (c), 14 (d), and 28 (e) days in vitro degradation. n = 7.
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Fig5: SEM images of Si-CaP/FPBP at day 0 (a), 3 (b), 7 (c), 14 (d), and 28 (e) days in vitro degradation. n = 7.

Mentions: Cross-section surface morphology of Si-CaP/FPBP scaffold was observed with SEM before in vitro degradation. We found that FPBP attached tightly to the surface of Si-CaP particles (Figure 5a). Si-CaP particles showed uniform short rod shape with size of approximately 2–10 µm. Si-CaP particles and FPBP were relatively uniform and positioned closely together. The Si-CaP/FPBP scaffold formed three-dimensional porous structures. The sizes of pores were approximately 150–300 µm with micropores of 1–10 µm distributed on the relatively smooth pore wall.Figure 5


Development and performance analysis of Si-CaP/fine particulate bone powder combined grafts for bone regeneration.

Sun C, Tian Y, Xu W, Zhou C, Xie H, Wang X - Biomed Eng Online (2015)

SEM images of Si-CaP/FPBP at day 0 (a), 3 (b), 7 (c), 14 (d), and 28 (e) days in vitro degradation. n = 7.
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4492003&req=5

Fig5: SEM images of Si-CaP/FPBP at day 0 (a), 3 (b), 7 (c), 14 (d), and 28 (e) days in vitro degradation. n = 7.
Mentions: Cross-section surface morphology of Si-CaP/FPBP scaffold was observed with SEM before in vitro degradation. We found that FPBP attached tightly to the surface of Si-CaP particles (Figure 5a). Si-CaP particles showed uniform short rod shape with size of approximately 2–10 µm. Si-CaP particles and FPBP were relatively uniform and positioned closely together. The Si-CaP/FPBP scaffold formed three-dimensional porous structures. The sizes of pores were approximately 150–300 µm with micropores of 1–10 µm distributed on the relatively smooth pore wall.Figure 5

Bottom Line: However, when applied individually, these two materials fall short of an ideal substitute material.Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis.Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, The Second Harbin City Hospital, Harbin, 150056, China. scl324@126.com.

ABSTRACT

Background: Although autogenous bone grafts as well as several bone graft substitute material have been used for some time, there is high demand for more efficient and less costly bone-substitute materials. Silicon-substituted calcium phosphates (Si-CaP) and fine particulate bone powder (FPBP) preparations have been previously shown to individually possess many of the required features of a bone graft substitute scaffold. However, when applied individually, these two materials fall short of an ideal substitute material. We investigated a new concept of combining Si-CaP with FPBP for improved performance in bone-repair.

Methods: We assessed Si-CaP/FPBP combined grafts in vitro, by measuring changes in pH, weight loss, water absorption and compressive strength over time.

Results: Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis.

Conclusion: Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually.

No MeSH data available.


Related in: MedlinePlus