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Development and performance analysis of Si-CaP/fine particulate bone powder combined grafts for bone regeneration.

Sun C, Tian Y, Xu W, Zhou C, Xie H, Wang X - Biomed Eng Online (2015)

Bottom Line: However, when applied individually, these two materials fall short of an ideal substitute material.Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis.Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, The Second Harbin City Hospital, Harbin, 150056, China. scl324@126.com.

ABSTRACT

Background: Although autogenous bone grafts as well as several bone graft substitute material have been used for some time, there is high demand for more efficient and less costly bone-substitute materials. Silicon-substituted calcium phosphates (Si-CaP) and fine particulate bone powder (FPBP) preparations have been previously shown to individually possess many of the required features of a bone graft substitute scaffold. However, when applied individually, these two materials fall short of an ideal substitute material. We investigated a new concept of combining Si-CaP with FPBP for improved performance in bone-repair.

Methods: We assessed Si-CaP/FPBP combined grafts in vitro, by measuring changes in pH, weight loss, water absorption and compressive strength over time.

Results: Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis.

Conclusion: Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually.

No MeSH data available.


Related in: MedlinePlus

a Light microscope image of FPBP. FPBP particle sizes were about 300–500 µm. b, c SEM images of FPBP at 200× (b) and 1,000× (c).
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Fig4: a Light microscope image of FPBP. FPBP particle sizes were about 300–500 µm. b, c SEM images of FPBP at 200× (b) and 1,000× (c).

Mentions: Bright field images showed that FPBP particles had irregular shape with bone debris scattered on the surface (Figure 4a). SEM was used to characterize the surface morphology of FPBP (Figure 4b, c). The FPBP was observed as a mixture of 10 μm porous cortical and cancellous bone. The majority was coarse cancellous bone.Figure 4


Development and performance analysis of Si-CaP/fine particulate bone powder combined grafts for bone regeneration.

Sun C, Tian Y, Xu W, Zhou C, Xie H, Wang X - Biomed Eng Online (2015)

a Light microscope image of FPBP. FPBP particle sizes were about 300–500 µm. b, c SEM images of FPBP at 200× (b) and 1,000× (c).
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4492003&req=5

Fig4: a Light microscope image of FPBP. FPBP particle sizes were about 300–500 µm. b, c SEM images of FPBP at 200× (b) and 1,000× (c).
Mentions: Bright field images showed that FPBP particles had irregular shape with bone debris scattered on the surface (Figure 4a). SEM was used to characterize the surface morphology of FPBP (Figure 4b, c). The FPBP was observed as a mixture of 10 μm porous cortical and cancellous bone. The majority was coarse cancellous bone.Figure 4

Bottom Line: However, when applied individually, these two materials fall short of an ideal substitute material.Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis.Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopaedic Surgery, The Second Harbin City Hospital, Harbin, 150056, China. scl324@126.com.

ABSTRACT

Background: Although autogenous bone grafts as well as several bone graft substitute material have been used for some time, there is high demand for more efficient and less costly bone-substitute materials. Silicon-substituted calcium phosphates (Si-CaP) and fine particulate bone powder (FPBP) preparations have been previously shown to individually possess many of the required features of a bone graft substitute scaffold. However, when applied individually, these two materials fall short of an ideal substitute material. We investigated a new concept of combining Si-CaP with FPBP for improved performance in bone-repair.

Methods: We assessed Si-CaP/FPBP combined grafts in vitro, by measuring changes in pH, weight loss, water absorption and compressive strength over time.

Results: Si-CaP/FPBP combined grafts was found to produce conditions of alkaline pH levels compared to FPBP, and scaffold surface morphology conducive to bone cell adhesion, proliferation, differentiation, tissue growth and transport of nutrients, while maintaining elasticity and mechanical strength and degradation at a rate closer to osteogenesis.

Conclusion: Si-CaP/FPBP combined grafts was found to be superior to any of the two components individually.

No MeSH data available.


Related in: MedlinePlus