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Free-Breathing 3D Imaging of Right Ventricular Structure and Function Using Respiratory and Cardiac Self-Gated Cine MRI.

Zhu Y, Liu J, Weinsaft J, Spincemaille P, Nguyen TD, Prince MR, Bao S, Xie Y, Wang Y - Biomed Res Int (2015)

Bottom Line: Providing a movie of the beating heart in a single prescribed plane, cine MRI has been widely used in clinical cardiac diagnosis, especially in the left ventricle (LV).High correlations between the two techniques were found (RVEDV: 0.94; RVESV: 0.85; RVSV: 0.95; and RVEF: 0.89).Compared with 2D, the 3D image quality measurements show a small reduction in blood SNR, myocardium-blood CNR, myocardium contrast, and image sharpness.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Nanshan District, Shenzhen 518055, China ; Beijing City Key Lab of Medical Physics and Engineering, School of Physics, Peking University, 201 Chengfu Road, Haidian District, Beijing 100871, China ; Department of Radiology, Weill Cornell Medical College, 515 East 71th Street, New York, NY 10021, USA.

ABSTRACT
Providing a movie of the beating heart in a single prescribed plane, cine MRI has been widely used in clinical cardiac diagnosis, especially in the left ventricle (LV). Right ventricular (RV) morphology and function are also important for the diagnosis of cardiopulmonary diseases and serve as predictors for the long term outcome. The purpose of this study is to develop a self-gated free-breathing 3D imaging method for RV quantification and to evaluate its performance by comparing it with breath-hold 2D cine imaging in 7 healthy volunteers. Compared with 2D, the 3D RV functional measurements show a reduction of RV end-diastole volume (RVEDV) by 10%, increase of RV end-systole volume (RVESV) by 1.8%, reduction of RV systole volume (RVSV) by 21%, and reduction of RV ejection fraction (RVEF) by 12%. High correlations between the two techniques were found (RVEDV: 0.94; RVESV: 0.85; RVSV: 0.95; and RVEF: 0.89). Compared with 2D, the 3D image quality measurements show a small reduction in blood SNR, myocardium-blood CNR, myocardium contrast, and image sharpness. In conclusion, the proposed self-gated free-breathing 3D cardiac cine imaging technique provides comparable image quality and correlated functional measurements to those acquired with the multiple breath-hold 2D technique in RV.

No MeSH data available.


Related in: MedlinePlus

Cardiac self-gating signal (red line) and respiratory self-gating signal (blue line) were synchronized and presented, respectively. Amplitudes of both curves were rescaled for display purposes only. The asterisk represents cardiac self-gating trigger. Note: AU: arbitrary unit.
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fig4: Cardiac self-gating signal (red line) and respiratory self-gating signal (blue line) were synchronized and presented, respectively. Amplitudes of both curves were rescaled for display purposes only. The asterisk represents cardiac self-gating trigger. Note: AU: arbitrary unit.

Mentions: All scans were completed successfully. Figure 4 shows an example of synchronized self-gating signals. Temporal resolutions of both self-gating signals were 61.6 ms. The valleys of cardiac self-gating curves were detected and used as trigger. The mean of heart rate and respiratory rate of the subject shown in Figure 4 is 55 bpm (beats per minutes) and 17 bpm (breaths per minute). Figure 5 shows the short-axis cardiac cine images obtained with breath-hold 2D and free-breathing 3D imaging during diastole and systole, demonstrating similar visualization of cardiac structures and excellent motion suppression of the developed self-gated 3D pulse sequence. Note that 3D imaging yielded 12 contiguous slices without gap, while 2D imaging only provided 10 slices with a 3 mm interslice gap. The 3D images have 61.6 ms temporal resolution and 1.2 × 1.2 mm2 in-plane spatial resolution, while the 2D images have 84 ms temporal resolution and 1.2 × 1.6 mm2 measured in-plane spatial resolution.


Free-Breathing 3D Imaging of Right Ventricular Structure and Function Using Respiratory and Cardiac Self-Gated Cine MRI.

Zhu Y, Liu J, Weinsaft J, Spincemaille P, Nguyen TD, Prince MR, Bao S, Xie Y, Wang Y - Biomed Res Int (2015)

Cardiac self-gating signal (red line) and respiratory self-gating signal (blue line) were synchronized and presented, respectively. Amplitudes of both curves were rescaled for display purposes only. The asterisk represents cardiac self-gating trigger. Note: AU: arbitrary unit.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4491385&req=5

fig4: Cardiac self-gating signal (red line) and respiratory self-gating signal (blue line) were synchronized and presented, respectively. Amplitudes of both curves were rescaled for display purposes only. The asterisk represents cardiac self-gating trigger. Note: AU: arbitrary unit.
Mentions: All scans were completed successfully. Figure 4 shows an example of synchronized self-gating signals. Temporal resolutions of both self-gating signals were 61.6 ms. The valleys of cardiac self-gating curves were detected and used as trigger. The mean of heart rate and respiratory rate of the subject shown in Figure 4 is 55 bpm (beats per minutes) and 17 bpm (breaths per minute). Figure 5 shows the short-axis cardiac cine images obtained with breath-hold 2D and free-breathing 3D imaging during diastole and systole, demonstrating similar visualization of cardiac structures and excellent motion suppression of the developed self-gated 3D pulse sequence. Note that 3D imaging yielded 12 contiguous slices without gap, while 2D imaging only provided 10 slices with a 3 mm interslice gap. The 3D images have 61.6 ms temporal resolution and 1.2 × 1.2 mm2 in-plane spatial resolution, while the 2D images have 84 ms temporal resolution and 1.2 × 1.6 mm2 measured in-plane spatial resolution.

Bottom Line: Providing a movie of the beating heart in a single prescribed plane, cine MRI has been widely used in clinical cardiac diagnosis, especially in the left ventricle (LV).High correlations between the two techniques were found (RVEDV: 0.94; RVESV: 0.85; RVSV: 0.95; and RVEF: 0.89).Compared with 2D, the 3D image quality measurements show a small reduction in blood SNR, myocardium-blood CNR, myocardium contrast, and image sharpness.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Nanshan District, Shenzhen 518055, China ; Beijing City Key Lab of Medical Physics and Engineering, School of Physics, Peking University, 201 Chengfu Road, Haidian District, Beijing 100871, China ; Department of Radiology, Weill Cornell Medical College, 515 East 71th Street, New York, NY 10021, USA.

ABSTRACT
Providing a movie of the beating heart in a single prescribed plane, cine MRI has been widely used in clinical cardiac diagnosis, especially in the left ventricle (LV). Right ventricular (RV) morphology and function are also important for the diagnosis of cardiopulmonary diseases and serve as predictors for the long term outcome. The purpose of this study is to develop a self-gated free-breathing 3D imaging method for RV quantification and to evaluate its performance by comparing it with breath-hold 2D cine imaging in 7 healthy volunteers. Compared with 2D, the 3D RV functional measurements show a reduction of RV end-diastole volume (RVEDV) by 10%, increase of RV end-systole volume (RVESV) by 1.8%, reduction of RV systole volume (RVSV) by 21%, and reduction of RV ejection fraction (RVEF) by 12%. High correlations between the two techniques were found (RVEDV: 0.94; RVESV: 0.85; RVSV: 0.95; and RVEF: 0.89). Compared with 2D, the 3D image quality measurements show a small reduction in blood SNR, myocardium-blood CNR, myocardium contrast, and image sharpness. In conclusion, the proposed self-gated free-breathing 3D cardiac cine imaging technique provides comparable image quality and correlated functional measurements to those acquired with the multiple breath-hold 2D technique in RV.

No MeSH data available.


Related in: MedlinePlus