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Three-times-weekly administration of teriparatide improves vertebral and peripheral bone density, microarchitecture, and mechanical properties without accelerating bone resorption in ovariectomized rats.

Takao-Kawabata R, Isogai Y, Takakura A, Shimazu Y, Sugimoto E, Nakazono O, Ikegaki I, Kuriyama H, Tanaka S, Oda H, Ishizuya T - Calcif. Tissue Int. (2015)

Bottom Line: Cortical thickness increased only toward the endocortical side of the femur, unlike with daily administration.Bone strength of the vertebrae and proximal and shaft of the femur was correlated with the changes in BMD and bone structure.These results demonstrate the effects of low frequency, intermittent administration of teriparatide on the biomechanical, and microstructural properties of bone in OVX rats.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Pharmacology, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, 632-1 Mifuku, Izunokuni, Shizuoka, 410-2321, Japan, takao.rb@om.asahi-kasei.co.jp.

ABSTRACT
Daily and weekly administration of teriparatide (PTH1-34) reduces the risk of osteoporotic bone fractures. However, their effects on markers of bone formation and bone resorption differ. These results indicate that the dosing frequency of teriparatide may affect bone metabolism and bone structure, with different effects on bone strength. In the present study, to evaluate the dose-related effects of a low administration frequency of teriparatide on bone status, we investigated the effects of three-times-weekly administration of teriparatide (1.1, 5.6, or 28.2 µg/kg) for 12 months on bone parameters, including bone metabolism markers, bone mineral density (BMD), micro-computed tomography, and bone strength, using 6-month-old ovariectomized (OVX) rats. Three-times-weekly administration of teriparatide dose-dependently increased the BMD of the lumbar vertebra and femur in OVX rats, and increased serum osteocalcin (a marker of bone formation), but not type I collagen C-telopeptide (a marker of bone resorption). The trabecular number and thickness increased in the vertebrae and femur, as in prior reports of daily teriparatide administration in OVX rats. Cortical thickness increased only toward the endocortical side of the femur, unlike with daily administration. Bone strength of the vertebrae and proximal and shaft of the femur was correlated with the changes in BMD and bone structure. These results demonstrate the effects of low frequency, intermittent administration of teriparatide on the biomechanical, and microstructural properties of bone in OVX rats.

No MeSH data available.


Related in: MedlinePlus

Correlations between the maximum load and bone density or structure parameters in the lumbar vertebra, proximal femur, and femoral shaft. r Spearman correlation coefficient, P P value
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Fig4: Correlations between the maximum load and bone density or structure parameters in the lumbar vertebra, proximal femur, and femoral shaft. r Spearman correlation coefficient, P P value

Mentions: The relationships between mechanical strength (maximum load) and BMD or structural parameters of the lumbar vertebra, femoral neck, and femoral shaft are shown in Fig. 4 for all rats combined. The maximum load was significantly correlated with the BMD of the lumbar vertebra (r = 0.933; Fig. 4a), proximal femur (r = 0.508; Fig. 4d), and femoral shaft (r = 0.757; Fig. 4g). The maximum load of the lumbar vertebra was positively correlated with Tb.Th (r = 0.786) and was negatively correlated with TBPf (r = −0.867) (Fig. 4b, c). The maximum load of the proximal femur was positively correlated with Tb.Th (r = 0.379) and Ct.Th (r = 0.405) in the inter-trochanter region (Fig. 4e, f). The maximum load of the femoral shaft was positively correlated with Ct.Th (r = 0.775) and was negatively correlated with In.L (r = −0.625) (Fig. 4h, i).Fig. 4


Three-times-weekly administration of teriparatide improves vertebral and peripheral bone density, microarchitecture, and mechanical properties without accelerating bone resorption in ovariectomized rats.

Takao-Kawabata R, Isogai Y, Takakura A, Shimazu Y, Sugimoto E, Nakazono O, Ikegaki I, Kuriyama H, Tanaka S, Oda H, Ishizuya T - Calcif. Tissue Int. (2015)

Correlations between the maximum load and bone density or structure parameters in the lumbar vertebra, proximal femur, and femoral shaft. r Spearman correlation coefficient, P P value
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4491365&req=5

Fig4: Correlations between the maximum load and bone density or structure parameters in the lumbar vertebra, proximal femur, and femoral shaft. r Spearman correlation coefficient, P P value
Mentions: The relationships between mechanical strength (maximum load) and BMD or structural parameters of the lumbar vertebra, femoral neck, and femoral shaft are shown in Fig. 4 for all rats combined. The maximum load was significantly correlated with the BMD of the lumbar vertebra (r = 0.933; Fig. 4a), proximal femur (r = 0.508; Fig. 4d), and femoral shaft (r = 0.757; Fig. 4g). The maximum load of the lumbar vertebra was positively correlated with Tb.Th (r = 0.786) and was negatively correlated with TBPf (r = −0.867) (Fig. 4b, c). The maximum load of the proximal femur was positively correlated with Tb.Th (r = 0.379) and Ct.Th (r = 0.405) in the inter-trochanter region (Fig. 4e, f). The maximum load of the femoral shaft was positively correlated with Ct.Th (r = 0.775) and was negatively correlated with In.L (r = −0.625) (Fig. 4h, i).Fig. 4

Bottom Line: Cortical thickness increased only toward the endocortical side of the femur, unlike with daily administration.Bone strength of the vertebrae and proximal and shaft of the femur was correlated with the changes in BMD and bone structure.These results demonstrate the effects of low frequency, intermittent administration of teriparatide on the biomechanical, and microstructural properties of bone in OVX rats.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Pharmacology, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, 632-1 Mifuku, Izunokuni, Shizuoka, 410-2321, Japan, takao.rb@om.asahi-kasei.co.jp.

ABSTRACT
Daily and weekly administration of teriparatide (PTH1-34) reduces the risk of osteoporotic bone fractures. However, their effects on markers of bone formation and bone resorption differ. These results indicate that the dosing frequency of teriparatide may affect bone metabolism and bone structure, with different effects on bone strength. In the present study, to evaluate the dose-related effects of a low administration frequency of teriparatide on bone status, we investigated the effects of three-times-weekly administration of teriparatide (1.1, 5.6, or 28.2 µg/kg) for 12 months on bone parameters, including bone metabolism markers, bone mineral density (BMD), micro-computed tomography, and bone strength, using 6-month-old ovariectomized (OVX) rats. Three-times-weekly administration of teriparatide dose-dependently increased the BMD of the lumbar vertebra and femur in OVX rats, and increased serum osteocalcin (a marker of bone formation), but not type I collagen C-telopeptide (a marker of bone resorption). The trabecular number and thickness increased in the vertebrae and femur, as in prior reports of daily teriparatide administration in OVX rats. Cortical thickness increased only toward the endocortical side of the femur, unlike with daily administration. Bone strength of the vertebrae and proximal and shaft of the femur was correlated with the changes in BMD and bone structure. These results demonstrate the effects of low frequency, intermittent administration of teriparatide on the biomechanical, and microstructural properties of bone in OVX rats.

No MeSH data available.


Related in: MedlinePlus