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Burden of illness associated with peripheral and central neuropathic pain among adults seeking treatment in the United States: a patient-centered evaluation.

Schaefer C, Mann R, Sadosky A, Daniel S, Parsons B, Nieshoff E, Tuchman M, Nalamachu S, Anschel A, Stacey BR - Pain Med (2014)

Bottom Line: Patient-reported outcomes (health status, physical and mental health, pain interference with function, sleep, anxiety, and depression) were significantly worse among subjects with greater pain severity (all P < 0.0001).Severe pain subjects were negatively impacted by ≥30% in each outcome compared with mild pain subjects; standardized effect size was moderate for anxiety (0.59) and large (>0.95) for all others.Subjects across NeP conditions exhibited high pain levels, which were significantly associated with poor function, compromised health status and sleep, and increased anxiety and depression.

View Article: PubMed Central - PubMed

Affiliation: Covance Market Access Services Inc., Gaithersburg, Maryland, USA.

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Trends across domains of sleep are consistent across NeP conditions*.*Significant differences were observed across NeP conditions for sleep disturbance, sleep adequacy, shortness of breath or headache domains (all P < 0.03).†Mean sleep disturbance for PTPS-NeP has been previously published [20].‡The sleep adequacy item differs from all others in that higher scores indicate better outcomes on this item.CLBP-NeP = chronic low back pain with a neuropathic pain component; HIV-NeP = human immunodeficiency virus-related peripheral neuropathic pain; NeP = neuropathic pain; pDPN = painful diabetic peripheral neuropathy; PTPS-NeP = post-trauma/post-surgery neuropathic pain; SCI-NeP = spinal cord injury-related neuropathic pain; SFN = painful peripheral neuropathy with small fiber involvement. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]
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fig06: Trends across domains of sleep are consistent across NeP conditions*.*Significant differences were observed across NeP conditions for sleep disturbance, sleep adequacy, shortness of breath or headache domains (all P < 0.03).†Mean sleep disturbance for PTPS-NeP has been previously published [20].‡The sleep adequacy item differs from all others in that higher scores indicate better outcomes on this item.CLBP-NeP = chronic low back pain with a neuropathic pain component; HIV-NeP = human immunodeficiency virus-related peripheral neuropathic pain; NeP = neuropathic pain; pDPN = painful diabetic peripheral neuropathy; PTPS-NeP = post-trauma/post-surgery neuropathic pain; SCI-NeP = spinal cord injury-related neuropathic pain; SFN = painful peripheral neuropathy with small fiber involvement. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]

Mentions: The mean MOS-SS subscale scores for each of the NeP conditions are presented in Figure 6. Mean scores exhibited a similar pattern across NeP conditions and were consistently the worst among CLBP-NeP subjects.


Burden of illness associated with peripheral and central neuropathic pain among adults seeking treatment in the United States: a patient-centered evaluation.

Schaefer C, Mann R, Sadosky A, Daniel S, Parsons B, Nieshoff E, Tuchman M, Nalamachu S, Anschel A, Stacey BR - Pain Med (2014)

Trends across domains of sleep are consistent across NeP conditions*.*Significant differences were observed across NeP conditions for sleep disturbance, sleep adequacy, shortness of breath or headache domains (all P < 0.03).†Mean sleep disturbance for PTPS-NeP has been previously published [20].‡The sleep adequacy item differs from all others in that higher scores indicate better outcomes on this item.CLBP-NeP = chronic low back pain with a neuropathic pain component; HIV-NeP = human immunodeficiency virus-related peripheral neuropathic pain; NeP = neuropathic pain; pDPN = painful diabetic peripheral neuropathy; PTPS-NeP = post-trauma/post-surgery neuropathic pain; SCI-NeP = spinal cord injury-related neuropathic pain; SFN = painful peripheral neuropathy with small fiber involvement. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4491355&req=5

fig06: Trends across domains of sleep are consistent across NeP conditions*.*Significant differences were observed across NeP conditions for sleep disturbance, sleep adequacy, shortness of breath or headache domains (all P < 0.03).†Mean sleep disturbance for PTPS-NeP has been previously published [20].‡The sleep adequacy item differs from all others in that higher scores indicate better outcomes on this item.CLBP-NeP = chronic low back pain with a neuropathic pain component; HIV-NeP = human immunodeficiency virus-related peripheral neuropathic pain; NeP = neuropathic pain; pDPN = painful diabetic peripheral neuropathy; PTPS-NeP = post-trauma/post-surgery neuropathic pain; SCI-NeP = spinal cord injury-related neuropathic pain; SFN = painful peripheral neuropathy with small fiber involvement. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]
Mentions: The mean MOS-SS subscale scores for each of the NeP conditions are presented in Figure 6. Mean scores exhibited a similar pattern across NeP conditions and were consistently the worst among CLBP-NeP subjects.

Bottom Line: Patient-reported outcomes (health status, physical and mental health, pain interference with function, sleep, anxiety, and depression) were significantly worse among subjects with greater pain severity (all P < 0.0001).Severe pain subjects were negatively impacted by ≥30% in each outcome compared with mild pain subjects; standardized effect size was moderate for anxiety (0.59) and large (>0.95) for all others.Subjects across NeP conditions exhibited high pain levels, which were significantly associated with poor function, compromised health status and sleep, and increased anxiety and depression.

View Article: PubMed Central - PubMed

Affiliation: Covance Market Access Services Inc., Gaithersburg, Maryland, USA.

Show MeSH
Related in: MedlinePlus