Burden of illness associated with peripheral and central neuropathic pain among adults seeking treatment in the United States: a patient-centered evaluation.
Bottom Line: Patient-reported outcomes (health status, physical and mental health, pain interference with function, sleep, anxiety, and depression) were significantly worse among subjects with greater pain severity (all P < 0.0001).Severe pain subjects were negatively impacted by ≥30% in each outcome compared with mild pain subjects; standardized effect size was moderate for anxiety (0.59) and large (>0.95) for all others.Subjects across NeP conditions exhibited high pain levels, which were significantly associated with poor function, compromised health status and sleep, and increased anxiety and depression.
Affiliation: Covance Market Access Services Inc., Gaithersburg, Maryland, USA.Show MeSH
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Mentions: Overall, the mean (SD) time since NeP diagnosis was 7.8 (6.8) years, with a longer duration of NeP observed among those with greater pain severity (P = 0.0059). On average, the time from appearance of NeP symptoms to diagnosis was 20 months (1.7 years). Approximately three-fourths of the sample reported being originally diagnosed by a primary care physician (39.3%), a neurologist (23.9%), or a pain specialist (11.4%) (data not shown). On average, subjects had approximately 3 comorbidities, with more comorbidities among those with greater pain severity (P < 0.0001). The most common comorbidities overall were depressive symptoms (42.6%), sleep disturbance/insomnia (42.1%), and anxiety (35.1%) (Figure 2). Seventy-four (11.9%) subjects were not able to walk on their own; 50 of these subjects were SCI-NeP subjects.
Affiliation: Covance Market Access Services Inc., Gaithersburg, Maryland, USA.