Burden of illness associated with peripheral and central neuropathic pain among adults seeking treatment in the United States: a patient-centered evaluation.
Bottom Line: Patient-reported outcomes (health status, physical and mental health, pain interference with function, sleep, anxiety, and depression) were significantly worse among subjects with greater pain severity (all P < 0.0001).Severe pain subjects were negatively impacted by ≥30% in each outcome compared with mild pain subjects; standardized effect size was moderate for anxiety (0.59) and large (>0.95) for all others.Subjects across NeP conditions exhibited high pain levels, which were significantly associated with poor function, compromised health status and sleep, and increased anxiety and depression.
Affiliation: Covance Market Access Services Inc., Gaithersburg, Maryland, USA.Show MeSH
Related in: MedlinePlus
Mentions: Subjects reported a mean (SD) pain severity score of 5.5 (2.2) overall. Close to half of the subjects (47.6%) reported moderate pain, while a third (33.2%) had severe pain. The majority of subjects reported suffering moderately to very strongly from a burning pain sensation (76.4%); a similar majority reported suffering moderately to very strongly from a prickling pain sensation (76.9%) (data not shown). The distribution of pain severity was similar across NeP conditions (Figure 1).
Affiliation: Covance Market Access Services Inc., Gaithersburg, Maryland, USA.