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Burden of illness associated with peripheral and central neuropathic pain among adults seeking treatment in the United States: a patient-centered evaluation.

Schaefer C, Mann R, Sadosky A, Daniel S, Parsons B, Nieshoff E, Tuchman M, Nalamachu S, Anschel A, Stacey BR - Pain Med (2014)

Bottom Line: Patient-reported outcomes (health status, physical and mental health, pain interference with function, sleep, anxiety, and depression) were significantly worse among subjects with greater pain severity (all P < 0.0001).Severe pain subjects were negatively impacted by ≥30% in each outcome compared with mild pain subjects; standardized effect size was moderate for anxiety (0.59) and large (>0.95) for all others.Subjects across NeP conditions exhibited high pain levels, which were significantly associated with poor function, compromised health status and sleep, and increased anxiety and depression.

View Article: PubMed Central - PubMed

Affiliation: Covance Market Access Services Inc., Gaithersburg, Maryland, USA.

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The majority of NeP subjects reported moderate or severe pain, regardless of NeP condition*.*Scores on the BPI-SF Pain Severity Index were used to classify average pain severity. Ten subjects did not respond to all required items needed to calculate a BPI-SF average pain severity score and thus were not included in any analysis by pain severity category (“missing”).†Pain severity levels for the individual NeP conditions have been previously published [15,20,37,38] or are being submitted for publication.BPI-SF = Brief Pain Inventory-Short Form; CLBP-NeP = chronic low back pain with a neuropathic pain component; HIV-NeP = human immunodeficiency virus-related peripheral neuropathic pain; NeP = neuropathic pain; pDPN = painful diabetic peripheral neuropathy; PTPS-NeP = post-trauma/post-surgery neuropathic pain; SCI-NeP = spinal cord injury-related neuropathic pain; SFN = painful peripheral neuropathy with small fiber involvement. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]
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fig01: The majority of NeP subjects reported moderate or severe pain, regardless of NeP condition*.*Scores on the BPI-SF Pain Severity Index were used to classify average pain severity. Ten subjects did not respond to all required items needed to calculate a BPI-SF average pain severity score and thus were not included in any analysis by pain severity category (“missing”).†Pain severity levels for the individual NeP conditions have been previously published [15,20,37,38] or are being submitted for publication.BPI-SF = Brief Pain Inventory-Short Form; CLBP-NeP = chronic low back pain with a neuropathic pain component; HIV-NeP = human immunodeficiency virus-related peripheral neuropathic pain; NeP = neuropathic pain; pDPN = painful diabetic peripheral neuropathy; PTPS-NeP = post-trauma/post-surgery neuropathic pain; SCI-NeP = spinal cord injury-related neuropathic pain; SFN = painful peripheral neuropathy with small fiber involvement. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]

Mentions: Subjects reported a mean (SD) pain severity score of 5.5 (2.2) overall. Close to half of the subjects (47.6%) reported moderate pain, while a third (33.2%) had severe pain. The majority of subjects reported suffering moderately to very strongly from a burning pain sensation (76.4%); a similar majority reported suffering moderately to very strongly from a prickling pain sensation (76.9%) (data not shown). The distribution of pain severity was similar across NeP conditions (Figure 1).


Burden of illness associated with peripheral and central neuropathic pain among adults seeking treatment in the United States: a patient-centered evaluation.

Schaefer C, Mann R, Sadosky A, Daniel S, Parsons B, Nieshoff E, Tuchman M, Nalamachu S, Anschel A, Stacey BR - Pain Med (2014)

The majority of NeP subjects reported moderate or severe pain, regardless of NeP condition*.*Scores on the BPI-SF Pain Severity Index were used to classify average pain severity. Ten subjects did not respond to all required items needed to calculate a BPI-SF average pain severity score and thus were not included in any analysis by pain severity category (“missing”).†Pain severity levels for the individual NeP conditions have been previously published [15,20,37,38] or are being submitted for publication.BPI-SF = Brief Pain Inventory-Short Form; CLBP-NeP = chronic low back pain with a neuropathic pain component; HIV-NeP = human immunodeficiency virus-related peripheral neuropathic pain; NeP = neuropathic pain; pDPN = painful diabetic peripheral neuropathy; PTPS-NeP = post-trauma/post-surgery neuropathic pain; SCI-NeP = spinal cord injury-related neuropathic pain; SFN = painful peripheral neuropathy with small fiber involvement. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4491355&req=5

fig01: The majority of NeP subjects reported moderate or severe pain, regardless of NeP condition*.*Scores on the BPI-SF Pain Severity Index were used to classify average pain severity. Ten subjects did not respond to all required items needed to calculate a BPI-SF average pain severity score and thus were not included in any analysis by pain severity category (“missing”).†Pain severity levels for the individual NeP conditions have been previously published [15,20,37,38] or are being submitted for publication.BPI-SF = Brief Pain Inventory-Short Form; CLBP-NeP = chronic low back pain with a neuropathic pain component; HIV-NeP = human immunodeficiency virus-related peripheral neuropathic pain; NeP = neuropathic pain; pDPN = painful diabetic peripheral neuropathy; PTPS-NeP = post-trauma/post-surgery neuropathic pain; SCI-NeP = spinal cord injury-related neuropathic pain; SFN = painful peripheral neuropathy with small fiber involvement. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]
Mentions: Subjects reported a mean (SD) pain severity score of 5.5 (2.2) overall. Close to half of the subjects (47.6%) reported moderate pain, while a third (33.2%) had severe pain. The majority of subjects reported suffering moderately to very strongly from a burning pain sensation (76.4%); a similar majority reported suffering moderately to very strongly from a prickling pain sensation (76.9%) (data not shown). The distribution of pain severity was similar across NeP conditions (Figure 1).

Bottom Line: Patient-reported outcomes (health status, physical and mental health, pain interference with function, sleep, anxiety, and depression) were significantly worse among subjects with greater pain severity (all P < 0.0001).Severe pain subjects were negatively impacted by ≥30% in each outcome compared with mild pain subjects; standardized effect size was moderate for anxiety (0.59) and large (>0.95) for all others.Subjects across NeP conditions exhibited high pain levels, which were significantly associated with poor function, compromised health status and sleep, and increased anxiety and depression.

View Article: PubMed Central - PubMed

Affiliation: Covance Market Access Services Inc., Gaithersburg, Maryland, USA.

Show MeSH
Related in: MedlinePlus