MRS water resonance frequency in childhood brain tumours: a novel potential biomarker of temperature and tumour environment.
Bottom Line: Mean PRF values were significantly larger for medulloblastoma compared with glioma, with a difference in the means of 0.0147 ppm (p < 0.05), while the mean PRF for glioma was significantly lower than for the healthy cohort, with a difference in the means of 0.0061 ppm (p < 0.05).Measurement of these effects could also be used as a supplementary biomarker, and further investigation is required.This study has shown that the water PRF value has the potential to be used for characterizing childhood brain tumours, which has not been reported previously.
Affiliation: School of Cancer Sciences, University of Birmingham, Birmingham, West Midlands, UK; Children's Hospital NHS Foundation Trust, Birmingham, West Midlands, UK.Show MeSH
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Mentions: Comparison of the individual water PRF shifts, δW(Cho) and δW(Cr) (Fig. 5) shows a similar trend, across the groups, to the amplitude-squared weighted results (Fig. 4). However, the SD was generally larger for the water PRF shifts calculated using individual metabolite references. Comparing the two individual metabolite reference plots, the Cr plot had consistently reduced mean PRF values across groups; however, only the medulloblastoma group PRF difference was significant, p < 0.05. The group SDs were similar for each individual metabolite reference, except for the glioma group, in which the SD for δW(Cr) was significantly larger, p < 0.05.
Affiliation: School of Cancer Sciences, University of Birmingham, Birmingham, West Midlands, UK; Children's Hospital NHS Foundation Trust, Birmingham, West Midlands, UK.