MRS water resonance frequency in childhood brain tumours: a novel potential biomarker of temperature and tumour environment.
Bottom Line: Mean PRF values were significantly larger for medulloblastoma compared with glioma, with a difference in the means of 0.0147 ppm (p < 0.05), while the mean PRF for glioma was significantly lower than for the healthy cohort, with a difference in the means of 0.0061 ppm (p < 0.05).Measurement of these effects could also be used as a supplementary biomarker, and further investigation is required.This study has shown that the water PRF value has the potential to be used for characterizing childhood brain tumours, which has not been reported previously.
Affiliation: School of Cancer Sciences, University of Birmingham, Birmingham, West Midlands, UK; Children's Hospital NHS Foundation Trust, Birmingham, West Midlands, UK.Show MeSH
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Mentions: Spectra were analysed in the jMRUI (jMRUI, Java Magnetic Resonance User Interface) software package using the AMARES tool (23). The Cr and the Cho peak were chosen as references since they were prominent in all tumour and healthy spectra. Mean spectra of the groups, with SD, were generated using MATLAB and normalized by the sum of the absolute real values in the frequency domain (0.5–4 ppm range) (see Figure 3 later).
Affiliation: School of Cancer Sciences, University of Birmingham, Birmingham, West Midlands, UK; Children's Hospital NHS Foundation Trust, Birmingham, West Midlands, UK.