MRS water resonance frequency in childhood brain tumours: a novel potential biomarker of temperature and tumour environment.
Bottom Line: Mean PRF values were significantly larger for medulloblastoma compared with glioma, with a difference in the means of 0.0147 ppm (p < 0.05), while the mean PRF for glioma was significantly lower than for the healthy cohort, with a difference in the means of 0.0061 ppm (p < 0.05).Measurement of these effects could also be used as a supplementary biomarker, and further investigation is required.This study has shown that the water PRF value has the potential to be used for characterizing childhood brain tumours, which has not been reported previously.
Affiliation: School of Cancer Sciences, University of Birmingham, Birmingham, West Midlands, UK; Children's Hospital NHS Foundation Trust, Birmingham, West Midlands, UK.Show MeSH
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Mentions: The PRF of water (δH2O), choline (δCho) and creatine (δCr) were determined in the frequency domain by correcting the zero order phase manually and fitting individual peaks with a Lorentzian profile. Chemical shifts of 4.68 ppm, 3.03 ppm and 3.22 ppm were used as initial estimates for fitting the H2O, Cr and Cho peaks respectively. Since NAA was not often readily detected in all tumour spectra, only water PRF shifts relative to Cr, δ(H2O – Cr), and Cho, δ(H20 – Cho), were determined for each spectrum (Fig. 2).
Affiliation: School of Cancer Sciences, University of Birmingham, Birmingham, West Midlands, UK; Children's Hospital NHS Foundation Trust, Birmingham, West Midlands, UK.