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The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis.

Pak KH, Jo A, Choi HJ, Choi Y, Kim H, Cheong JH - BMC Cancer (2015)

Bottom Line: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics.P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05).We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Hallym University Medical Center, Hwasung, South Korea. sweetpkh@gmail.com.

ABSTRACT

Background: Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD) has been controversial in gastric cancer. The purpose of this study was to investigate the differences of clinicopathologic characteristics with respect to I-LVD and P-LVD in gastric cancer.

Methods: Samples of I-LVD and P-LVD from 66 patients who had undergone radical gastrectomy for gastric cancer were assessed after staining with D2-40, an immunostaining marker for lymphatic endothelium. The mean number of lymphatic vessels in three hotspots was calculated in intratumoral and peritumoral areas.

Results: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics. I-LVD was positively correlated with diffuse gastric cancer subtype, tumor stage, lymphovascular invasion, tumor node metastasis stage, and overall survival (P < 0.05). P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05).

Conclusions: We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion. However, both LVDs contributed to gastric cancer progression and prognosis.

No MeSH data available.


Related in: MedlinePlus

Survival curve according to the intratumoral lympho-vascular density (I-LVD). a Disease-free survival, b overall survival
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Fig4: Survival curve according to the intratumoral lympho-vascular density (I-LVD). a Disease-free survival, b overall survival

Mentions: The correlations of I-LVD and P-LVD with clinicopathological parameters are shown in Table 1. Neither I-LVD nor P-LVD correlated with age, sex, extent of resection, tumor location, or tumor size. In addition to the association of I-LVD with the diffuse type of cancer, it was also significantly associated with the undifferentiated type (P = 0.021), tumor stage (T-stage; P = 0.024), LVI (P = 0.004), tumor node metastasis (TNM) stage (P = 0.029), and poor overall survival (P = 0.031; refer also to Fig. 4 a and b). Although it failed to reach statistical significance, the data showed a trend for I-LVD to associate with node (N)-stage (P = 0.052). In comparison, P-LVD had a significant correlation with LVI (P = 0.028), N-stage (P = 0.040), poor disease-free survival (P = 0.037; also refer to Fig. 5a), and a tendency for association with TNM-stage (P = 0.061) and overall survival (P = 0.088, Fig. 5b). Lauren classification, differentiation, and T-stage were not correlated with P-LVD.Fig. 4


The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis.

Pak KH, Jo A, Choi HJ, Choi Y, Kim H, Cheong JH - BMC Cancer (2015)

Survival curve according to the intratumoral lympho-vascular density (I-LVD). a Disease-free survival, b overall survival
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4491256&req=5

Fig4: Survival curve according to the intratumoral lympho-vascular density (I-LVD). a Disease-free survival, b overall survival
Mentions: The correlations of I-LVD and P-LVD with clinicopathological parameters are shown in Table 1. Neither I-LVD nor P-LVD correlated with age, sex, extent of resection, tumor location, or tumor size. In addition to the association of I-LVD with the diffuse type of cancer, it was also significantly associated with the undifferentiated type (P = 0.021), tumor stage (T-stage; P = 0.024), LVI (P = 0.004), tumor node metastasis (TNM) stage (P = 0.029), and poor overall survival (P = 0.031; refer also to Fig. 4 a and b). Although it failed to reach statistical significance, the data showed a trend for I-LVD to associate with node (N)-stage (P = 0.052). In comparison, P-LVD had a significant correlation with LVI (P = 0.028), N-stage (P = 0.040), poor disease-free survival (P = 0.037; also refer to Fig. 5a), and a tendency for association with TNM-stage (P = 0.061) and overall survival (P = 0.088, Fig. 5b). Lauren classification, differentiation, and T-stage were not correlated with P-LVD.Fig. 4

Bottom Line: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics.P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05).We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Hallym University Medical Center, Hwasung, South Korea. sweetpkh@gmail.com.

ABSTRACT

Background: Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD) has been controversial in gastric cancer. The purpose of this study was to investigate the differences of clinicopathologic characteristics with respect to I-LVD and P-LVD in gastric cancer.

Methods: Samples of I-LVD and P-LVD from 66 patients who had undergone radical gastrectomy for gastric cancer were assessed after staining with D2-40, an immunostaining marker for lymphatic endothelium. The mean number of lymphatic vessels in three hotspots was calculated in intratumoral and peritumoral areas.

Results: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics. I-LVD was positively correlated with diffuse gastric cancer subtype, tumor stage, lymphovascular invasion, tumor node metastasis stage, and overall survival (P < 0.05). P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05).

Conclusions: We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion. However, both LVDs contributed to gastric cancer progression and prognosis.

No MeSH data available.


Related in: MedlinePlus