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The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis.

Pak KH, Jo A, Choi HJ, Choi Y, Kim H, Cheong JH - BMC Cancer (2015)

Bottom Line: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics.P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05).We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Hallym University Medical Center, Hwasung, South Korea. sweetpkh@gmail.com.

ABSTRACT

Background: Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD) has been controversial in gastric cancer. The purpose of this study was to investigate the differences of clinicopathologic characteristics with respect to I-LVD and P-LVD in gastric cancer.

Methods: Samples of I-LVD and P-LVD from 66 patients who had undergone radical gastrectomy for gastric cancer were assessed after staining with D2-40, an immunostaining marker for lymphatic endothelium. The mean number of lymphatic vessels in three hotspots was calculated in intratumoral and peritumoral areas.

Results: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics. I-LVD was positively correlated with diffuse gastric cancer subtype, tumor stage, lymphovascular invasion, tumor node metastasis stage, and overall survival (P < 0.05). P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05).

Conclusions: We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion. However, both LVDs contributed to gastric cancer progression and prognosis.

No MeSH data available.


Related in: MedlinePlus

Intratumoral lymphatics containing tumor (Lymphovascular invasion)
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Fig2: Intratumoral lymphatics containing tumor (Lymphovascular invasion)

Mentions: The D2-40-positive lymphatic vessels had irregular morphology and thin-walled lumens. Lymphatic vessels in gastric tissues were mostly located in the layer of submucosa. Intratumoral lymphatic vessels were usually collapsed, small, and irregular in all intestinal and diffuse types (Fig. 1a and b), but some non-collapsed lymphatics had open lumens and occasionally contained invading tumor-cell clusters (Fig. 2). The peritumoral lymphatic vessels were enlarged with dilated lymphatic cavities, regardless of their Lauren classification (Fig. 3a and b). Overall, the mean I-LVD was higher than the mean P-LVD (12.29 ± 4.35 vs. 11.01 ± 3.62 [±SD throughout], P = 0.025). In addition, the mean I-LVD of the intestinal and diffuse subtypes was significantly different (11.20 ± 3.06 vs. 13.27 ± 5.09, respectively, P = 0.048). However, the P-LVD of the two subtypes was not significantly different..Fig. 1


The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis.

Pak KH, Jo A, Choi HJ, Choi Y, Kim H, Cheong JH - BMC Cancer (2015)

Intratumoral lymphatics containing tumor (Lymphovascular invasion)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4491256&req=5

Fig2: Intratumoral lymphatics containing tumor (Lymphovascular invasion)
Mentions: The D2-40-positive lymphatic vessels had irregular morphology and thin-walled lumens. Lymphatic vessels in gastric tissues were mostly located in the layer of submucosa. Intratumoral lymphatic vessels were usually collapsed, small, and irregular in all intestinal and diffuse types (Fig. 1a and b), but some non-collapsed lymphatics had open lumens and occasionally contained invading tumor-cell clusters (Fig. 2). The peritumoral lymphatic vessels were enlarged with dilated lymphatic cavities, regardless of their Lauren classification (Fig. 3a and b). Overall, the mean I-LVD was higher than the mean P-LVD (12.29 ± 4.35 vs. 11.01 ± 3.62 [±SD throughout], P = 0.025). In addition, the mean I-LVD of the intestinal and diffuse subtypes was significantly different (11.20 ± 3.06 vs. 13.27 ± 5.09, respectively, P = 0.048). However, the P-LVD of the two subtypes was not significantly different..Fig. 1

Bottom Line: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics.P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05).We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Hallym University Medical Center, Hwasung, South Korea. sweetpkh@gmail.com.

ABSTRACT

Background: Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD) has been controversial in gastric cancer. The purpose of this study was to investigate the differences of clinicopathologic characteristics with respect to I-LVD and P-LVD in gastric cancer.

Methods: Samples of I-LVD and P-LVD from 66 patients who had undergone radical gastrectomy for gastric cancer were assessed after staining with D2-40, an immunostaining marker for lymphatic endothelium. The mean number of lymphatic vessels in three hotspots was calculated in intratumoral and peritumoral areas.

Results: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics. I-LVD was positively correlated with diffuse gastric cancer subtype, tumor stage, lymphovascular invasion, tumor node metastasis stage, and overall survival (P < 0.05). P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05).

Conclusions: We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion. However, both LVDs contributed to gastric cancer progression and prognosis.

No MeSH data available.


Related in: MedlinePlus