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Ataxia induced by a thymic neuroblastoma in the elderly patient.

Wiesel O, Bhattacharyya S, Vaitkevicius H, Prasad S, McNamee C - World J Surg Oncol (2015)

Bottom Line: Thymic neuroblastoma is a rare tumor with only few reports in modern literature.We report a case of a 62-year-old male who presented with neurological symptoms of ataxia and opsoclonus and an anterior mediastinal mass.This is the first case of thymic neuroblastoma associated with symptomatic central nervous system disease; it is presented with an up-to-date review of the previous cases in the field as well with a review of the literature of post adolescent neuroblastoma.

View Article: PubMed Central - PubMed

Affiliation: Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75th Francis Street, Boston, 02115, MA, USA. owiesel@partners.org.

ABSTRACT
Thymic neuroblastoma is a rare tumor with only few reports in modern literature. Whereas most data is taken from childhood neuroblastoma, little is known about the characteristics of the disease in the adult and elderly population. There are significant differences between adult and childhood neuroblastoma which are reviewed below. We report a case of a 62-year-old male who presented with neurological symptoms of ataxia and opsoclonus and an anterior mediastinal mass. Ultimately, the patient underwent a resection of the mass and pathologic review identified a thymic neuroblastoma. This is the first case of thymic neuroblastoma associated with symptomatic central nervous system disease; it is presented with an up-to-date review of the previous cases in the field as well with a review of the literature of post adolescent neuroblastoma.

No MeSH data available.


Related in: MedlinePlus

Axial section of initial CT scan with the anterior mediastinal mass abutting the pericardium.
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Fig1: Axial section of initial CT scan with the anterior mediastinal mass abutting the pericardium.

Mentions: A previously asymptomatic 62-year-old male presented with ataxia and oscillopsia with progression over a 6-week interval. On physical examination, the patient was noted to have horizontal and vertical opsoclonus, truncal ataxia, right eye ptosis, and a hoarse voice. A chest CT was done and an anterior mediastinal mass was found (Figure 1). A magnetic resonance imaging (MRI) of the mediastinum revealed an anterior mediastinal mass extending from the distal ascending aorta to the right ventricular free wall with a smaller adjacent nodule, both abutting but not invading the neighboring structures. The mass was hyperintense on T1 and T2, with avid enhancement during first pass perfusion and heterogeneous enhancement on delayed images. Positron emission tomography (PET)/CT revealed a 5.2 × 3.8 cm anterior mediastinal mass with a superior satellite nodule (1.8 × 1.5 cm); both showed intense FDG avidity (Figure 2).Figure 1


Ataxia induced by a thymic neuroblastoma in the elderly patient.

Wiesel O, Bhattacharyya S, Vaitkevicius H, Prasad S, McNamee C - World J Surg Oncol (2015)

Axial section of initial CT scan with the anterior mediastinal mass abutting the pericardium.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4491252&req=5

Fig1: Axial section of initial CT scan with the anterior mediastinal mass abutting the pericardium.
Mentions: A previously asymptomatic 62-year-old male presented with ataxia and oscillopsia with progression over a 6-week interval. On physical examination, the patient was noted to have horizontal and vertical opsoclonus, truncal ataxia, right eye ptosis, and a hoarse voice. A chest CT was done and an anterior mediastinal mass was found (Figure 1). A magnetic resonance imaging (MRI) of the mediastinum revealed an anterior mediastinal mass extending from the distal ascending aorta to the right ventricular free wall with a smaller adjacent nodule, both abutting but not invading the neighboring structures. The mass was hyperintense on T1 and T2, with avid enhancement during first pass perfusion and heterogeneous enhancement on delayed images. Positron emission tomography (PET)/CT revealed a 5.2 × 3.8 cm anterior mediastinal mass with a superior satellite nodule (1.8 × 1.5 cm); both showed intense FDG avidity (Figure 2).Figure 1

Bottom Line: Thymic neuroblastoma is a rare tumor with only few reports in modern literature.We report a case of a 62-year-old male who presented with neurological symptoms of ataxia and opsoclonus and an anterior mediastinal mass.This is the first case of thymic neuroblastoma associated with symptomatic central nervous system disease; it is presented with an up-to-date review of the previous cases in the field as well with a review of the literature of post adolescent neuroblastoma.

View Article: PubMed Central - PubMed

Affiliation: Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75th Francis Street, Boston, 02115, MA, USA. owiesel@partners.org.

ABSTRACT
Thymic neuroblastoma is a rare tumor with only few reports in modern literature. Whereas most data is taken from childhood neuroblastoma, little is known about the characteristics of the disease in the adult and elderly population. There are significant differences between adult and childhood neuroblastoma which are reviewed below. We report a case of a 62-year-old male who presented with neurological symptoms of ataxia and opsoclonus and an anterior mediastinal mass. Ultimately, the patient underwent a resection of the mass and pathologic review identified a thymic neuroblastoma. This is the first case of thymic neuroblastoma associated with symptomatic central nervous system disease; it is presented with an up-to-date review of the previous cases in the field as well with a review of the literature of post adolescent neuroblastoma.

No MeSH data available.


Related in: MedlinePlus