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An adjustable fetal weight standard for twins: a statistical modeling study.

Zhang J, Mikolajczyk R, Lei X, Sun L, Yu H, Cheng W - BMC Med (2015)

Bottom Line: The adjustable fetal weight standard has an excellent match with the observed birthweight data in non-Hispanic White, non-Hispanic Black, Hispanics, and Asian from 24 to 38 weeks gestation.It also had a very good fit with cross-sectional data from Australia and Norway, and a longitudinal standard from Brazil.The adjustable fetal weight standard for twins is a flexible tool and can be used in different populations.

View Article: PubMed Central - PubMed

Affiliation: MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. junjimzhang@gmail.com.

ABSTRACT

Background: It is a common practice to use a singleton fetal growth standard to assess twin growth. We aim to create a twin fetal weight standard which is also adjustable for race/ethnicity and other factors.

Methods: Over half a million twin births of low risk pregnancies in the US, from 1995 to 2004, were used to construct a fetal weight standard. We used the Hadlock's fetal growth standard and the proportionality principle to make the standard adjustable for other factors such as race/ethnicity. We validated the standard in different race/ethnicities in the US and against previously published curves from around the world.

Results: The adjustable fetal weight standard has an excellent match with the observed birthweight data in non-Hispanic White, non-Hispanic Black, Hispanics, and Asian from 24 to 38 weeks gestation. It also had a very good fit with cross-sectional data from Australia and Norway, and a longitudinal standard from Brazil. However, our model-based 10th and 90th percentiles differed substantially from studies in Japan and US that used the last menstrual period for estimate of gestational age.

Conclusion: The adjustable fetal weight standard for twins is a flexible tool and can be used in different populations.

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Related in: MedlinePlus

Subject selection process, the US Linked Live Birth and Infant Death Database, 1995–2004
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Fig1: Subject selection process, the US Linked Live Birth and Infant Death Database, 1995–2004

Mentions: There were 1,157,393 twins in the linked 1995–2004 birth and infant death dataset (Fig. 1). We restricted our analysis to low risk twin live births, i.e., women with reliable gestational age and birthweight, maternal age between 20 and 35 years, high school graduate or higher education, non-smokers, no hypertensive disorders in pregnancy or pre-existing or gestational diabetes, and prenatal care started in first trimester, leaving 536,479 twins for the final analysis.Fig. 1


An adjustable fetal weight standard for twins: a statistical modeling study.

Zhang J, Mikolajczyk R, Lei X, Sun L, Yu H, Cheng W - BMC Med (2015)

Subject selection process, the US Linked Live Birth and Infant Death Database, 1995–2004
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4491250&req=5

Fig1: Subject selection process, the US Linked Live Birth and Infant Death Database, 1995–2004
Mentions: There were 1,157,393 twins in the linked 1995–2004 birth and infant death dataset (Fig. 1). We restricted our analysis to low risk twin live births, i.e., women with reliable gestational age and birthweight, maternal age between 20 and 35 years, high school graduate or higher education, non-smokers, no hypertensive disorders in pregnancy or pre-existing or gestational diabetes, and prenatal care started in first trimester, leaving 536,479 twins for the final analysis.Fig. 1

Bottom Line: The adjustable fetal weight standard has an excellent match with the observed birthweight data in non-Hispanic White, non-Hispanic Black, Hispanics, and Asian from 24 to 38 weeks gestation.It also had a very good fit with cross-sectional data from Australia and Norway, and a longitudinal standard from Brazil.The adjustable fetal weight standard for twins is a flexible tool and can be used in different populations.

View Article: PubMed Central - PubMed

Affiliation: MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. junjimzhang@gmail.com.

ABSTRACT

Background: It is a common practice to use a singleton fetal growth standard to assess twin growth. We aim to create a twin fetal weight standard which is also adjustable for race/ethnicity and other factors.

Methods: Over half a million twin births of low risk pregnancies in the US, from 1995 to 2004, were used to construct a fetal weight standard. We used the Hadlock's fetal growth standard and the proportionality principle to make the standard adjustable for other factors such as race/ethnicity. We validated the standard in different race/ethnicities in the US and against previously published curves from around the world.

Results: The adjustable fetal weight standard has an excellent match with the observed birthweight data in non-Hispanic White, non-Hispanic Black, Hispanics, and Asian from 24 to 38 weeks gestation. It also had a very good fit with cross-sectional data from Australia and Norway, and a longitudinal standard from Brazil. However, our model-based 10th and 90th percentiles differed substantially from studies in Japan and US that used the last menstrual period for estimate of gestational age.

Conclusion: The adjustable fetal weight standard for twins is a flexible tool and can be used in different populations.

Show MeSH
Related in: MedlinePlus