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Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China.

Wang R, Guo XL, Wisman GB, Schuuring E, Wang WF, Zeng ZY, Zhu H, Wu SW - BMC Infect. Dis. (2015)

Bottom Line: A total of 111,131 samples were tested by Hybrid Capture II and the other 9,641 were genotyped using the Tellgenplex™ HPV DNA Assay.The total positive rate for hrHPV was 21.07 %, which ranged from 18.42 % (Nanchang) to 31.94 % (Haikou) and varied by region.Overall, the most prevalent genotypes were HPV16 (4.82 %) and HPV52 (4.52 %), followed by HPV58 (2.74 %).

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Microbiology, School of Laboratory Medicine, Tianjin Medical University, Tianjin, China. wangrong825@126.com.

ABSTRACT

Background: Type-specific high-risk HPV (hrHPV) infection is related to cervical carcinogenesis. The prevalence of hrHPV infection varies geographically, which might reflect the epidemiological characteristics of cervical cancer among different populations. To establish a foundation for HPV-based screening and vaccination programs in China, we investigated the most recent HPV prevalence and genotypic distributions in different female age groups and geographical regions in China.

Methods: In 2012, a total of 120,772 liquid-based cytological samples from women enrolled for population- or employee-based cervical screening in 37 Chinese cities were obtained by the Laboratory of Molecular Infectious Diseases of Guangzhou KingMed. A total of 111,131 samples were tested by Hybrid Capture II and the other 9,641 were genotyped using the Tellgenplex™ HPV DNA Assay.

Results: The total positive rate for hrHPV was 21.07 %, which ranged from 18.42 % (Nanchang) to 31.94 % (Haikou) and varied by region. The regions of Nanchang, Changsha, Hangzhou, Chengdu, Fuzhou, Guangdong, and Guiyang could be considered the low prevalence regions. Age-specific prevalence showed a "two-peak" pattern, with the youngest age group (15-19 years) presenting the highest hrHPV infection rate (30.55 %), followed by a second peak for the 50-60-year-old group. Overall, the most prevalent genotypes were HPV16 (4.82 %) and HPV52 (4.52 %), followed by HPV58 (2.74 %). Two genotypes HPV6 (4.01 %) and HPV11 (2.29 %) were predominant in the low-risk HPV (lrHPV) type, while the mixed genotypes HPV16 + 52 and HPV52 + 58 were most common in women with multiple infections.

Conclusions: This study shows that HPV infection in China has increased to the level of an "HPV-heavy-burden" zone in certain regions, with prevalence varying significantly among different ages and regions. Data from this study represent the most current survey of the nationwide prevalence of HPV infection in China, and can serve as valuable reference to guide nationwide cervical cancer screening and HPV vaccination programs.

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The prevalence of each genotype hrHPV in multiple infections by Tellgenplex™ HPV DNA Test
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Fig3: The prevalence of each genotype hrHPV in multiple infections by Tellgenplex™ HPV DNA Test

Mentions: Infection with multiple HPVs was detected in a total of 486 specimens (5.04 %), among which 434 (16.82 %) and 52 (6.16 %) were infected with hrHPVs and lrHPVs, respectively. In the multiple hrHPV infection individuals, the frequencies of 6, 5, 4, 3, and 2 genotypes were 0.23 %, 1.84 %, 4.61 %, 17.74 %, and 75.58 %, respectively, and three genotypes showed higher positive rates, i.e., HPV16 (35.02 %), HPV52 (32.26 %), and HPV58 (21.20 %) (Fig. 3). The top most common combinations of strains were HPV16 + HPV52 (26 cases) and HPV52 + HPV58 (14 cases) (Additional file 1: Table S3.). For the individuals with multiple lrHPV infections, the proportion of those with 4, 3, and 2 genotypes were 1.92 %, 3.85 %, and 94.23 %, respectively.Fig. 3


Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China.

Wang R, Guo XL, Wisman GB, Schuuring E, Wang WF, Zeng ZY, Zhu H, Wu SW - BMC Infect. Dis. (2015)

The prevalence of each genotype hrHPV in multiple infections by Tellgenplex™ HPV DNA Test
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4491249&req=5

Fig3: The prevalence of each genotype hrHPV in multiple infections by Tellgenplex™ HPV DNA Test
Mentions: Infection with multiple HPVs was detected in a total of 486 specimens (5.04 %), among which 434 (16.82 %) and 52 (6.16 %) were infected with hrHPVs and lrHPVs, respectively. In the multiple hrHPV infection individuals, the frequencies of 6, 5, 4, 3, and 2 genotypes were 0.23 %, 1.84 %, 4.61 %, 17.74 %, and 75.58 %, respectively, and three genotypes showed higher positive rates, i.e., HPV16 (35.02 %), HPV52 (32.26 %), and HPV58 (21.20 %) (Fig. 3). The top most common combinations of strains were HPV16 + HPV52 (26 cases) and HPV52 + HPV58 (14 cases) (Additional file 1: Table S3.). For the individuals with multiple lrHPV infections, the proportion of those with 4, 3, and 2 genotypes were 1.92 %, 3.85 %, and 94.23 %, respectively.Fig. 3

Bottom Line: A total of 111,131 samples were tested by Hybrid Capture II and the other 9,641 were genotyped using the Tellgenplex™ HPV DNA Assay.The total positive rate for hrHPV was 21.07 %, which ranged from 18.42 % (Nanchang) to 31.94 % (Haikou) and varied by region.Overall, the most prevalent genotypes were HPV16 (4.82 %) and HPV52 (4.52 %), followed by HPV58 (2.74 %).

View Article: PubMed Central - PubMed

Affiliation: Division of Clinical Microbiology, School of Laboratory Medicine, Tianjin Medical University, Tianjin, China. wangrong825@126.com.

ABSTRACT

Background: Type-specific high-risk HPV (hrHPV) infection is related to cervical carcinogenesis. The prevalence of hrHPV infection varies geographically, which might reflect the epidemiological characteristics of cervical cancer among different populations. To establish a foundation for HPV-based screening and vaccination programs in China, we investigated the most recent HPV prevalence and genotypic distributions in different female age groups and geographical regions in China.

Methods: In 2012, a total of 120,772 liquid-based cytological samples from women enrolled for population- or employee-based cervical screening in 37 Chinese cities were obtained by the Laboratory of Molecular Infectious Diseases of Guangzhou KingMed. A total of 111,131 samples were tested by Hybrid Capture II and the other 9,641 were genotyped using the Tellgenplex™ HPV DNA Assay.

Results: The total positive rate for hrHPV was 21.07 %, which ranged from 18.42 % (Nanchang) to 31.94 % (Haikou) and varied by region. The regions of Nanchang, Changsha, Hangzhou, Chengdu, Fuzhou, Guangdong, and Guiyang could be considered the low prevalence regions. Age-specific prevalence showed a "two-peak" pattern, with the youngest age group (15-19 years) presenting the highest hrHPV infection rate (30.55 %), followed by a second peak for the 50-60-year-old group. Overall, the most prevalent genotypes were HPV16 (4.82 %) and HPV52 (4.52 %), followed by HPV58 (2.74 %). Two genotypes HPV6 (4.01 %) and HPV11 (2.29 %) were predominant in the low-risk HPV (lrHPV) type, while the mixed genotypes HPV16 + 52 and HPV52 + 58 were most common in women with multiple infections.

Conclusions: This study shows that HPV infection in China has increased to the level of an "HPV-heavy-burden" zone in certain regions, with prevalence varying significantly among different ages and regions. Data from this study represent the most current survey of the nationwide prevalence of HPV infection in China, and can serve as valuable reference to guide nationwide cervical cancer screening and HPV vaccination programs.

Show MeSH
Related in: MedlinePlus