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Review: Polymeric-Based 3D Printing for Tissue Engineering.

Wu GH, Hsu SH - J Med Biol Eng (2015)

Bottom Line: Suitable scaffolds can be designed and custom-made based on medical images such as those obtained from computed tomography.There are advantages and limitations for each method.Future areas of interest and progress are the development of new 3D printing platforms, scaffold design software, and materials for tissue engineering applications.

View Article: PubMed Central - PubMed

Affiliation: Institute of Polymer Science and Engineering, National Taiwan University, No. 1, Sec. 4 Roosevelt Road, Taipei, 10617 Taiwan, ROC.

ABSTRACT

Three-dimensional (3D) printing, also referred to as additive manufacturing, is a technology that allows for customized fabrication through computer-aided design. 3D printing has many advantages in the fabrication of tissue engineering scaffolds, including fast fabrication, high precision, and customized production. Suitable scaffolds can be designed and custom-made based on medical images such as those obtained from computed tomography. Many 3D printing methods have been employed for tissue engineering. There are advantages and limitations for each method. Future areas of interest and progress are the development of new 3D printing platforms, scaffold design software, and materials for tissue engineering applications.

No MeSH data available.


Scheme of fused deposition manufacturing (FDM). Melted polymer is extruded from nozzle to build scaffold
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Fig1: Scheme of fused deposition manufacturing (FDM). Melted polymer is extruded from nozzle to build scaffold

Mentions: Various additive manufacturing techniques have been applied in tissue engineering. They can be categorized into two large groups according to the power source used during fabrication, namely heat or light. Fused deposition modeling (FDM) is a typical heat-using technique for 3D scaffold fabrication. A scheme of FDM is shown in Fig. 1. In this method, the filament of the desired material is fed and melted in a liquefier by heat before extrusion from the nozzle. The melted polymer is extruded from the nozzle and deposited layer by layer to create a scaffold. The process temperature depends on the melting temperature of building materials and is generally too high for cells to survive or for bioactive molecules to retain their activity. Zein et al. [11] fabricated a honeycomb-structured polycaprolactone (PCL) scaffold that has a channel size of 160–700 µm, a filament diameter of 260–370 µm, and a porosity of 48–77 %. The working temperature was determined as 125 ± 5 °C, which is considered a relatively narrow process window for polymer processing. Hsu et al. used poly(d,l-lactide) (PLA) as the feed material. Scaffolds with various fiber stacking orientations were produced and examined [12]. They also fabricated scaffolds with concentric cylinder geometry (with interconnected hollows) and tested them. Furthermore, collagen was placed in a poly(d,l-lactide-co-glycolide) (PLGA) scaffold to promote chondrocyte growth [13].Fig. 1


Review: Polymeric-Based 3D Printing for Tissue Engineering.

Wu GH, Hsu SH - J Med Biol Eng (2015)

Scheme of fused deposition manufacturing (FDM). Melted polymer is extruded from nozzle to build scaffold
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4491116&req=5

Fig1: Scheme of fused deposition manufacturing (FDM). Melted polymer is extruded from nozzle to build scaffold
Mentions: Various additive manufacturing techniques have been applied in tissue engineering. They can be categorized into two large groups according to the power source used during fabrication, namely heat or light. Fused deposition modeling (FDM) is a typical heat-using technique for 3D scaffold fabrication. A scheme of FDM is shown in Fig. 1. In this method, the filament of the desired material is fed and melted in a liquefier by heat before extrusion from the nozzle. The melted polymer is extruded from the nozzle and deposited layer by layer to create a scaffold. The process temperature depends on the melting temperature of building materials and is generally too high for cells to survive or for bioactive molecules to retain their activity. Zein et al. [11] fabricated a honeycomb-structured polycaprolactone (PCL) scaffold that has a channel size of 160–700 µm, a filament diameter of 260–370 µm, and a porosity of 48–77 %. The working temperature was determined as 125 ± 5 °C, which is considered a relatively narrow process window for polymer processing. Hsu et al. used poly(d,l-lactide) (PLA) as the feed material. Scaffolds with various fiber stacking orientations were produced and examined [12]. They also fabricated scaffolds with concentric cylinder geometry (with interconnected hollows) and tested them. Furthermore, collagen was placed in a poly(d,l-lactide-co-glycolide) (PLGA) scaffold to promote chondrocyte growth [13].Fig. 1

Bottom Line: Suitable scaffolds can be designed and custom-made based on medical images such as those obtained from computed tomography.There are advantages and limitations for each method.Future areas of interest and progress are the development of new 3D printing platforms, scaffold design software, and materials for tissue engineering applications.

View Article: PubMed Central - PubMed

Affiliation: Institute of Polymer Science and Engineering, National Taiwan University, No. 1, Sec. 4 Roosevelt Road, Taipei, 10617 Taiwan, ROC.

ABSTRACT

Three-dimensional (3D) printing, also referred to as additive manufacturing, is a technology that allows for customized fabrication through computer-aided design. 3D printing has many advantages in the fabrication of tissue engineering scaffolds, including fast fabrication, high precision, and customized production. Suitable scaffolds can be designed and custom-made based on medical images such as those obtained from computed tomography. Many 3D printing methods have been employed for tissue engineering. There are advantages and limitations for each method. Future areas of interest and progress are the development of new 3D printing platforms, scaffold design software, and materials for tissue engineering applications.

No MeSH data available.