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Computational Fluid Dynamics Study of Bifurcation Aneurysms Treated with Pipeline Embolization Device: Side Branch Diameter Study.

Tang AY, Chung WC, Liu ET, Qu JQ, Tsang AC, Leung GK, Leung KM, Yu AC, Chow KW - J Med Biol Eng (2015)

Bottom Line: This may result in side-branch hypoperfusion subsequent to stenting.Furthermore, the peripheral resistance of downstream vessels is investigated by varying the outlet pressure conditions.This quantitative analysis can assist in treatment planning and therapeutic decision-making.

View Article: PubMed Central - PubMed

Affiliation: Department of Mechanical Engineering, The University of Hong Kong, Pokfulam, Hong Kong, 999077 China.

ABSTRACT

An intracranial aneurysm, abnormal swelling of the cerebral artery, may lead to undesirable rates of mortality and morbidity upon rupture. Endovascular treatment involves the deployment of a flow-diverting stent that covers the aneurysm orifice, thereby reducing the blood flow into the aneurysm and mitigating the risk of rupture. In this study, computational fluid dynamics analysis is performed on a bifurcation model to investigate the change in hemodynamics with various side branch diameters. The condition after the deployment of a pipeline embolization device is also simulated. Hemodynamic factors such as flow velocity, pressure, and wall shear stress are studied. Aneurysms with a larger side branch vessel might have greater risk after treatment in terms of hemodynamics. Although a stent could lead to flow reduction entering the aneurysm, it would drastically alter the flow rate inside the side branch vessel. This may result in side-branch hypoperfusion subsequent to stenting. In addition, two patient-specific bifurcation aneurysms are tested, and the results show good agreement with the idealized models. Furthermore, the peripheral resistance of downstream vessels is investigated by varying the outlet pressure conditions. This quantitative analysis can assist in treatment planning and therapeutic decision-making.

No MeSH data available.


Related in: MedlinePlus

3D vector diagrams near aneurysm neck for two patient-specific models. Drastic flow reduction inside aneurysm is observed in both patients after stent deployment
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Fig8: 3D vector diagrams near aneurysm neck for two patient-specific models. Drastic flow reduction inside aneurysm is observed in both patients after stent deployment

Mentions: Two patient-specific bifurcation aneurysms with linear dimensions similar to that of the idealized model, i.e., side branch diameter of about d = 1.0 mm, are investigated in this study. The 3D velocity vector plots of both patients before and after stent placement are similar to those observed for the idealized model (Fig. 8). In addition, the flow-diverting stent can dramatically reduce the volume influx into the aneurysm. The maximum pressure inside the aneurysm also drops after stenting for both patients, with reductions of 0.4 and 0.3 mmHg for Patient 1 and Patient 2, respectively. The trend and magnitude of these data are consistent with the conclusions made in Sect. 3.1.1.Fig. 8


Computational Fluid Dynamics Study of Bifurcation Aneurysms Treated with Pipeline Embolization Device: Side Branch Diameter Study.

Tang AY, Chung WC, Liu ET, Qu JQ, Tsang AC, Leung GK, Leung KM, Yu AC, Chow KW - J Med Biol Eng (2015)

3D vector diagrams near aneurysm neck for two patient-specific models. Drastic flow reduction inside aneurysm is observed in both patients after stent deployment
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4491114&req=5

Fig8: 3D vector diagrams near aneurysm neck for two patient-specific models. Drastic flow reduction inside aneurysm is observed in both patients after stent deployment
Mentions: Two patient-specific bifurcation aneurysms with linear dimensions similar to that of the idealized model, i.e., side branch diameter of about d = 1.0 mm, are investigated in this study. The 3D velocity vector plots of both patients before and after stent placement are similar to those observed for the idealized model (Fig. 8). In addition, the flow-diverting stent can dramatically reduce the volume influx into the aneurysm. The maximum pressure inside the aneurysm also drops after stenting for both patients, with reductions of 0.4 and 0.3 mmHg for Patient 1 and Patient 2, respectively. The trend and magnitude of these data are consistent with the conclusions made in Sect. 3.1.1.Fig. 8

Bottom Line: This may result in side-branch hypoperfusion subsequent to stenting.Furthermore, the peripheral resistance of downstream vessels is investigated by varying the outlet pressure conditions.This quantitative analysis can assist in treatment planning and therapeutic decision-making.

View Article: PubMed Central - PubMed

Affiliation: Department of Mechanical Engineering, The University of Hong Kong, Pokfulam, Hong Kong, 999077 China.

ABSTRACT

An intracranial aneurysm, abnormal swelling of the cerebral artery, may lead to undesirable rates of mortality and morbidity upon rupture. Endovascular treatment involves the deployment of a flow-diverting stent that covers the aneurysm orifice, thereby reducing the blood flow into the aneurysm and mitigating the risk of rupture. In this study, computational fluid dynamics analysis is performed on a bifurcation model to investigate the change in hemodynamics with various side branch diameters. The condition after the deployment of a pipeline embolization device is also simulated. Hemodynamic factors such as flow velocity, pressure, and wall shear stress are studied. Aneurysms with a larger side branch vessel might have greater risk after treatment in terms of hemodynamics. Although a stent could lead to flow reduction entering the aneurysm, it would drastically alter the flow rate inside the side branch vessel. This may result in side-branch hypoperfusion subsequent to stenting. In addition, two patient-specific bifurcation aneurysms are tested, and the results show good agreement with the idealized models. Furthermore, the peripheral resistance of downstream vessels is investigated by varying the outlet pressure conditions. This quantitative analysis can assist in treatment planning and therapeutic decision-making.

No MeSH data available.


Related in: MedlinePlus