Limits...
Angiosarcoma of the Head and Neck.

Mullins B, Hackman T - Int Arch Otorhinolaryngol (2015)

Bottom Line: We compared our results to the literature from 1979 to 2013.Results Mean follow-up was 42 months.The study highlights the importance of attaining negative margins during surgical resection, the utility of adjuvant therapies, as well as the need for continued research in developing new management strategies.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology/Head and Neck Oncology, University of North Carolina Hospitals, Chapel Hill, North Carolina, United States.

ABSTRACT
Introduction Angiosarcoma of the head and neck is a rare vascular sarcoma associated with high rates of local recurrence and distant metastasis and a poor prognosis. Objective We describe our experience treating patients with angiosarcoma of the head and neck to evaluate the outcomes, patterns of failure, and current treatments. Methods We identified six patients with angiosarcoma of the head and neck and treated at our institution between 2000 and 2013. We compared our results to the literature from 1979 to 2013. Results Mean follow-up was 42 months. Local recurrence rate was 50% with disease-specific survival and 2-year disease-free survival rates of 33.3 and 20%, respectively. Prognostic factors included tumor size > 5 cm and surgical margin status, with no correlation between histologic grade and survival. Combined-modality therapy was only used for aggressive tumors with positive surgical margins but is suggested to improve local control and overall survival. Conclusions Our data series supports that angiosarcoma of the head and neck has a high rate of recurrence and is associated with a poor prognosis, despite current combined-modality therapy. The study highlights the importance of attaining negative margins during surgical resection, the utility of adjuvant therapies, as well as the need for continued research in developing new management strategies.

No MeSH data available.


Related in: MedlinePlus

Hematoxylin and eosin staining of a tumor section of patient 2 demonstrating extensive dermal involvement by angiosarcoma (×40 magnification).
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4490918&req=5

FI0182or-1: Hematoxylin and eosin staining of a tumor section of patient 2 demonstrating extensive dermal involvement by angiosarcoma (×40 magnification).

Mentions: During diagnosis, all patients had a thorough clinical workup, physical examination, and either computed tomography or magnetic resonance imaging of the tumor. On imaging, tumor sizes ranged from 2.2 to 7.5 cm. Tumors were biopsied for final pathologic confirmation (Figs. 1 and 2).


Angiosarcoma of the Head and Neck.

Mullins B, Hackman T - Int Arch Otorhinolaryngol (2015)

Hematoxylin and eosin staining of a tumor section of patient 2 demonstrating extensive dermal involvement by angiosarcoma (×40 magnification).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4490918&req=5

FI0182or-1: Hematoxylin and eosin staining of a tumor section of patient 2 demonstrating extensive dermal involvement by angiosarcoma (×40 magnification).
Mentions: During diagnosis, all patients had a thorough clinical workup, physical examination, and either computed tomography or magnetic resonance imaging of the tumor. On imaging, tumor sizes ranged from 2.2 to 7.5 cm. Tumors were biopsied for final pathologic confirmation (Figs. 1 and 2).

Bottom Line: We compared our results to the literature from 1979 to 2013.Results Mean follow-up was 42 months.The study highlights the importance of attaining negative margins during surgical resection, the utility of adjuvant therapies, as well as the need for continued research in developing new management strategies.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology/Head and Neck Oncology, University of North Carolina Hospitals, Chapel Hill, North Carolina, United States.

ABSTRACT
Introduction Angiosarcoma of the head and neck is a rare vascular sarcoma associated with high rates of local recurrence and distant metastasis and a poor prognosis. Objective We describe our experience treating patients with angiosarcoma of the head and neck to evaluate the outcomes, patterns of failure, and current treatments. Methods We identified six patients with angiosarcoma of the head and neck and treated at our institution between 2000 and 2013. We compared our results to the literature from 1979 to 2013. Results Mean follow-up was 42 months. Local recurrence rate was 50% with disease-specific survival and 2-year disease-free survival rates of 33.3 and 20%, respectively. Prognostic factors included tumor size > 5 cm and surgical margin status, with no correlation between histologic grade and survival. Combined-modality therapy was only used for aggressive tumors with positive surgical margins but is suggested to improve local control and overall survival. Conclusions Our data series supports that angiosarcoma of the head and neck has a high rate of recurrence and is associated with a poor prognosis, despite current combined-modality therapy. The study highlights the importance of attaining negative margins during surgical resection, the utility of adjuvant therapies, as well as the need for continued research in developing new management strategies.

No MeSH data available.


Related in: MedlinePlus