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Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL.

Matena J, Petersen S, Gieseke M, Teske M, Beyerbach M, Kampmann A, Murua Escobar H, Gellrich NC, Haferkamp H, Nolte I - Int J Mol Sci (2015)

Bottom Line: The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process.For testing the biocompatibility, we used primary murine osteoblasts.Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating.

View Article: PubMed Central - PubMed

Affiliation: Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany. julia.matena@tiho-hannover.de.

ABSTRACT
Degradable implant material for bone remodeling that corresponds to the physiological stability of bone has still not been developed. Promising degradable materials with good mechanical properties are magnesium and magnesium alloys. However, excessive gas production due to corrosion can lower the biocompatibility. In the present study we used the polymer coating polycaprolactone (PCL), intended to lower the corrosion rate of magnesium. Additionally, improvement of implant geometry can increase bone remodeling. Porous structures are known to support vessel ingrowth and thus increase osseointegration. With the selective laser melting (SLM) process, defined open porous structures can be created. Recently, highly reactive magnesium has also been processed by SLM. We performed studies with a flat magnesium layer and with porous magnesium implants coated with polymers. The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process. For testing the biocompatibility, we used primary murine osteoblasts. Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating.

No MeSH data available.


Related in: MedlinePlus

Osteoblasts seeded on titanium and magnesium implant. The cell number development (A) and the cell spreading area development (B) over seven days were examined.
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ijms-16-13287-f006: Osteoblasts seeded on titanium and magnesium implant. The cell number development (A) and the cell spreading area development (B) over seven days were examined.

Mentions: Daily pictures of living cells successfully were imaged for both implant materials and were analyzed for development in cell spreading area and cell count of osteoblasts (Figure 6A,B). Comparing the results of cell spreading area and cell count, there was no difference between the two regression curves. The value of spreading area of cells settled on magnesium implant is higher than on titanium implants. Total cell numbers are higher on titanium implants in comparison with magnesium implants. A Statistical comparison test of the two regression coefficients, using an analysis of covariance, with a test of the interaction between the two implant materials and time with p < 0.05 was performed.


Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL.

Matena J, Petersen S, Gieseke M, Teske M, Beyerbach M, Kampmann A, Murua Escobar H, Gellrich NC, Haferkamp H, Nolte I - Int J Mol Sci (2015)

Osteoblasts seeded on titanium and magnesium implant. The cell number development (A) and the cell spreading area development (B) over seven days were examined.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490495&req=5

ijms-16-13287-f006: Osteoblasts seeded on titanium and magnesium implant. The cell number development (A) and the cell spreading area development (B) over seven days were examined.
Mentions: Daily pictures of living cells successfully were imaged for both implant materials and were analyzed for development in cell spreading area and cell count of osteoblasts (Figure 6A,B). Comparing the results of cell spreading area and cell count, there was no difference between the two regression curves. The value of spreading area of cells settled on magnesium implant is higher than on titanium implants. Total cell numbers are higher on titanium implants in comparison with magnesium implants. A Statistical comparison test of the two regression coefficients, using an analysis of covariance, with a test of the interaction between the two implant materials and time with p < 0.05 was performed.

Bottom Line: The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process.For testing the biocompatibility, we used primary murine osteoblasts.Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating.

View Article: PubMed Central - PubMed

Affiliation: Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany. julia.matena@tiho-hannover.de.

ABSTRACT
Degradable implant material for bone remodeling that corresponds to the physiological stability of bone has still not been developed. Promising degradable materials with good mechanical properties are magnesium and magnesium alloys. However, excessive gas production due to corrosion can lower the biocompatibility. In the present study we used the polymer coating polycaprolactone (PCL), intended to lower the corrosion rate of magnesium. Additionally, improvement of implant geometry can increase bone remodeling. Porous structures are known to support vessel ingrowth and thus increase osseointegration. With the selective laser melting (SLM) process, defined open porous structures can be created. Recently, highly reactive magnesium has also been processed by SLM. We performed studies with a flat magnesium layer and with porous magnesium implants coated with polymers. The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process. For testing the biocompatibility, we used primary murine osteoblasts. Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating.

No MeSH data available.


Related in: MedlinePlus