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Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL.

Matena J, Petersen S, Gieseke M, Teske M, Beyerbach M, Kampmann A, Murua Escobar H, Gellrich NC, Haferkamp H, Nolte I - Int J Mol Sci (2015)

Bottom Line: The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process.For testing the biocompatibility, we used primary murine osteoblasts.Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating.

View Article: PubMed Central - PubMed

Affiliation: Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany. julia.matena@tiho-hannover.de.

ABSTRACT
Degradable implant material for bone remodeling that corresponds to the physiological stability of bone has still not been developed. Promising degradable materials with good mechanical properties are magnesium and magnesium alloys. However, excessive gas production due to corrosion can lower the biocompatibility. In the present study we used the polymer coating polycaprolactone (PCL), intended to lower the corrosion rate of magnesium. Additionally, improvement of implant geometry can increase bone remodeling. Porous structures are known to support vessel ingrowth and thus increase osseointegration. With the selective laser melting (SLM) process, defined open porous structures can be created. Recently, highly reactive magnesium has also been processed by SLM. We performed studies with a flat magnesium layer and with porous magnesium implants coated with polymers. The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process. For testing the biocompatibility, we used primary murine osteoblasts. Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating.

No MeSH data available.


Related in: MedlinePlus

ESEM image of a magnesium PCL implant. Two different zones of the PCL coating were analyzed, named the external coating and the internal coating.
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ijms-16-13287-f005: ESEM image of a magnesium PCL implant. Two different zones of the PCL coating were analyzed, named the external coating and the internal coating.

Mentions: The magnesium implant was coated with PCL via a manual dip-coating process. Cross-section polishes of scaffolds were prepared to determine thickness of PCL coatings. The focus was put on the external coating, in order to evaluate the coating at the edge of the scaffold and on the internal coating with the 600 µm holes, which should enhance the angiogenesis (Figure 5). During dip coating, the direction of scaffold position was changed after each dip process in order to improve the coating homogeneity. For the external coating, a high thickness at the top, which decreases with increasing deepness of scaffold, was observed. For the internal coating a uniform thickness over the whole cross section was evaluated (Table 2).


Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL.

Matena J, Petersen S, Gieseke M, Teske M, Beyerbach M, Kampmann A, Murua Escobar H, Gellrich NC, Haferkamp H, Nolte I - Int J Mol Sci (2015)

ESEM image of a magnesium PCL implant. Two different zones of the PCL coating were analyzed, named the external coating and the internal coating.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490495&req=5

ijms-16-13287-f005: ESEM image of a magnesium PCL implant. Two different zones of the PCL coating were analyzed, named the external coating and the internal coating.
Mentions: The magnesium implant was coated with PCL via a manual dip-coating process. Cross-section polishes of scaffolds were prepared to determine thickness of PCL coatings. The focus was put on the external coating, in order to evaluate the coating at the edge of the scaffold and on the internal coating with the 600 µm holes, which should enhance the angiogenesis (Figure 5). During dip coating, the direction of scaffold position was changed after each dip process in order to improve the coating homogeneity. For the external coating, a high thickness at the top, which decreases with increasing deepness of scaffold, was observed. For the internal coating a uniform thickness over the whole cross section was evaluated (Table 2).

Bottom Line: The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process.For testing the biocompatibility, we used primary murine osteoblasts.Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating.

View Article: PubMed Central - PubMed

Affiliation: Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany. julia.matena@tiho-hannover.de.

ABSTRACT
Degradable implant material for bone remodeling that corresponds to the physiological stability of bone has still not been developed. Promising degradable materials with good mechanical properties are magnesium and magnesium alloys. However, excessive gas production due to corrosion can lower the biocompatibility. In the present study we used the polymer coating polycaprolactone (PCL), intended to lower the corrosion rate of magnesium. Additionally, improvement of implant geometry can increase bone remodeling. Porous structures are known to support vessel ingrowth and thus increase osseointegration. With the selective laser melting (SLM) process, defined open porous structures can be created. Recently, highly reactive magnesium has also been processed by SLM. We performed studies with a flat magnesium layer and with porous magnesium implants coated with polymers. The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process. For testing the biocompatibility, we used primary murine osteoblasts. Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating.

No MeSH data available.


Related in: MedlinePlus