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Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus.

Ma K, Li J, Fang Y, Lu L - Int J Mol Sci (2015)

Bottom Line: Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells.The B cell-intrinsic TLR signals play critical roles during lupus process.Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology and Center of Infection and Immunology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China. kongyang@hku.hk.

ABSTRACT
Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.

No MeSH data available.


Related in: MedlinePlus

TLR signals in B cell subpopulations. B-1 cells, transitional B cells, marginal zone B cells, germinal center B cells as well as memory B cells are responsive to TLR ligation. B-1 cells are highly sensitive to the ligation of TLR, 2, 4, 7 and 9. CpG ligates the TLR9 in transitional B cells. Marginal zone B cells are more sensitive to the ligation of LPS and CpG. Germinal center B cells respond to TLR4 ligation whereas TLR9 is highly expressed in CD27− memory B cells.
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ijms-16-13084-f001: TLR signals in B cell subpopulations. B-1 cells, transitional B cells, marginal zone B cells, germinal center B cells as well as memory B cells are responsive to TLR ligation. B-1 cells are highly sensitive to the ligation of TLR, 2, 4, 7 and 9. CpG ligates the TLR9 in transitional B cells. Marginal zone B cells are more sensitive to the ligation of LPS and CpG. Germinal center B cells respond to TLR4 ligation whereas TLR9 is highly expressed in CD27− memory B cells.

Mentions: Both B1a and B1b cells from B-1 cells and newly formed B cells, transitional B cells, FO B cells, MZ B cells from conventional B-2 cell pool can recognize TLR ligands, but they show differential responses to TLR ligation. More sensitive TLR signals are found in B-1 cells and MZ B cells. Increased number of B-1 cells is observed in lupus-prone mice and peripheral blood of SLE patients [18,24,25]. Similarly, the enlarged population of MZ B cells is also detected in lupus-prone BXSB mice and markedly contributes to anti-dsDNA autoantibody production [26,27]. Besides B-1 cells and MZ B cells, transitional B cells, germinal center B cells and memory B cells are also highly responsive to certain TLR ligation (Figure 1).


Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus.

Ma K, Li J, Fang Y, Lu L - Int J Mol Sci (2015)

TLR signals in B cell subpopulations. B-1 cells, transitional B cells, marginal zone B cells, germinal center B cells as well as memory B cells are responsive to TLR ligation. B-1 cells are highly sensitive to the ligation of TLR, 2, 4, 7 and 9. CpG ligates the TLR9 in transitional B cells. Marginal zone B cells are more sensitive to the ligation of LPS and CpG. Germinal center B cells respond to TLR4 ligation whereas TLR9 is highly expressed in CD27− memory B cells.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490487&req=5

ijms-16-13084-f001: TLR signals in B cell subpopulations. B-1 cells, transitional B cells, marginal zone B cells, germinal center B cells as well as memory B cells are responsive to TLR ligation. B-1 cells are highly sensitive to the ligation of TLR, 2, 4, 7 and 9. CpG ligates the TLR9 in transitional B cells. Marginal zone B cells are more sensitive to the ligation of LPS and CpG. Germinal center B cells respond to TLR4 ligation whereas TLR9 is highly expressed in CD27− memory B cells.
Mentions: Both B1a and B1b cells from B-1 cells and newly formed B cells, transitional B cells, FO B cells, MZ B cells from conventional B-2 cell pool can recognize TLR ligands, but they show differential responses to TLR ligation. More sensitive TLR signals are found in B-1 cells and MZ B cells. Increased number of B-1 cells is observed in lupus-prone mice and peripheral blood of SLE patients [18,24,25]. Similarly, the enlarged population of MZ B cells is also detected in lupus-prone BXSB mice and markedly contributes to anti-dsDNA autoantibody production [26,27]. Besides B-1 cells and MZ B cells, transitional B cells, germinal center B cells and memory B cells are also highly responsive to certain TLR ligation (Figure 1).

Bottom Line: Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells.The B cell-intrinsic TLR signals play critical roles during lupus process.Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology and Center of Infection and Immunology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China. kongyang@hku.hk.

ABSTRACT
Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.

No MeSH data available.


Related in: MedlinePlus