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Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases.

Korbecki J, Baranowska-Bosiacka I, Gutowska I, Chlubek D - Int J Mol Sci (2015)

Bottom Line: We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling.We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA2.For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland. jan.korbecki@onet.eu.

ABSTRACT
This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling. We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA2. For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds.

No MeSH data available.


Related in: MedlinePlus

Effect of vanadium compounds on the selected processes in the expression and activity of COXs. Vanadium compounds at different concentrations cause changes (gray) in COXs protein and mRNA expression. These processes are associated with activation of NF-κB. In addition to the effects on the expression of COX, vanadium compounds also increase the activity of COX through the activation of cPLA2. This process is due to the influx of Ca2+, among other things. ??–unknown data
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ijms-16-12648-f001: Effect of vanadium compounds on the selected processes in the expression and activity of COXs. Vanadium compounds at different concentrations cause changes (gray) in COXs protein and mRNA expression. These processes are associated with activation of NF-κB. In addition to the effects on the expression of COX, vanadium compounds also increase the activity of COX through the activation of cPLA2. This process is due to the influx of Ca2+, among other things. ??–unknown data

Mentions: In addition to its potential medicinal properties, vanadium compounds can also cause poisonings, which constitutes another important area of research on vanadium. Its normal human blood concentrations of about 1 nM, associated with the natural presence of vanadium compounds [13], may significantly increase in the conditions of considerable anthropogenic vanadium pollution in industrialized and highly urbanized areas [14,15,16,17]. The pollution results from the combustion of oil and coal which contain large amounts of vanadium [18,19], for example, blood vanadium levels in the population of Taiwan is ca 10 nM [20] and in factory workers occupationally exposed to vanadium-containing dust may exceed 4 μM [13]. At this last concentration, vanadium compounds exhibit therapeutic properties in vivo in diabetic rats [4,21] and in vitro in human tumor cells [22]. Nevertheless, at a concentration of 7.5 μM vanadium compounds activate the Ca2+-dependent cytoplasmic phospholipase A2 (cPLA2), which increases the synthesis of metabolites of arachidonic acid (AA) (Figure 1) [23,24,25,26]. Prostanoids have important functions in physiology but are also an important factor in the pathology of many diseases. The main pro-inflammatory prostaglandin, prostaglandin E2 (PGE2) inhibits apoptosis and stimulates tumor cell division [27]. Therefore drugs used in tumor therapy, as well as those used in chronic diabetes management, should not increase PGE2 synthesis.


Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases.

Korbecki J, Baranowska-Bosiacka I, Gutowska I, Chlubek D - Int J Mol Sci (2015)

Effect of vanadium compounds on the selected processes in the expression and activity of COXs. Vanadium compounds at different concentrations cause changes (gray) in COXs protein and mRNA expression. These processes are associated with activation of NF-κB. In addition to the effects on the expression of COX, vanadium compounds also increase the activity of COX through the activation of cPLA2. This process is due to the influx of Ca2+, among other things. ??–unknown data
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490466&req=5

ijms-16-12648-f001: Effect of vanadium compounds on the selected processes in the expression and activity of COXs. Vanadium compounds at different concentrations cause changes (gray) in COXs protein and mRNA expression. These processes are associated with activation of NF-κB. In addition to the effects on the expression of COX, vanadium compounds also increase the activity of COX through the activation of cPLA2. This process is due to the influx of Ca2+, among other things. ??–unknown data
Mentions: In addition to its potential medicinal properties, vanadium compounds can also cause poisonings, which constitutes another important area of research on vanadium. Its normal human blood concentrations of about 1 nM, associated with the natural presence of vanadium compounds [13], may significantly increase in the conditions of considerable anthropogenic vanadium pollution in industrialized and highly urbanized areas [14,15,16,17]. The pollution results from the combustion of oil and coal which contain large amounts of vanadium [18,19], for example, blood vanadium levels in the population of Taiwan is ca 10 nM [20] and in factory workers occupationally exposed to vanadium-containing dust may exceed 4 μM [13]. At this last concentration, vanadium compounds exhibit therapeutic properties in vivo in diabetic rats [4,21] and in vitro in human tumor cells [22]. Nevertheless, at a concentration of 7.5 μM vanadium compounds activate the Ca2+-dependent cytoplasmic phospholipase A2 (cPLA2), which increases the synthesis of metabolites of arachidonic acid (AA) (Figure 1) [23,24,25,26]. Prostanoids have important functions in physiology but are also an important factor in the pathology of many diseases. The main pro-inflammatory prostaglandin, prostaglandin E2 (PGE2) inhibits apoptosis and stimulates tumor cell division [27]. Therefore drugs used in tumor therapy, as well as those used in chronic diabetes management, should not increase PGE2 synthesis.

Bottom Line: We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling.We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA2.For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland. jan.korbecki@onet.eu.

ABSTRACT
This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling. We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA2. For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds.

No MeSH data available.


Related in: MedlinePlus