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Effect of oral taurine on morbidity and mortality in elderly hip fracture patients: a randomized trial.

Van Stijn MF, Bruins AA, Vermeulen MA, Witlox J, Teerlink T, Schoorl MG, De Bandt JP, Twisk JW, Van Leeuwen PA, Houdijk AP - Int J Mol Sci (2015)

Bottom Line: Taurine supplementation did not improve in-hospital morbidity, medical comorbidities during the first year, or mortality during the first year.Taurine supplementation lowered postoperative oxidative stress, as shown by lower urinary 8-hydroxy-2-deoxyguanosine levels (Generalized estimating equations (GEE) analysis average difference over time; regression coefficient (Beta): -0.54; 95% CI: -1.08--0.01; p = 0.04), blunted plasma malondialdehyde response (Beta: 1.58; 95% CI: 0.00-3.15; p = 0.05) and a trend towards lower lactate to pyruvate ratio (Beta: -1.10; 95% CI: -2.33-0.12; p = 0.08).We concluded that peri-operative taurine supplementation attenuated postoperative oxidative stress in elderly hip fracture patients, but did not improve postoperative morbidity and mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Medical Center Alkmaar, Wilhelminalaan 12, 1815 JD Alkmaar, The Netherlands. m.f.vanstijn@amc.uva.nl.

ABSTRACT
Hip fracture patients represent a large part of the elderly surgical population and face severe postoperative morbidity and excessive mortality compared to adult surgical hip fracture patients. Low antioxidant status and taurine deficiency is common in the elderly, and may negatively affect postoperative outcome. We hypothesized that taurine, an antioxidant, could improve clinical outcome in the elderly hip fracture patient. A double blind randomized, placebo controlled, clinical trial was conducted on elderly hip fracture patients. Supplementation started after admission and before surgery up to the sixth postoperative day. Markers of oxidative status were measured during hospitalization, and postoperative outcome was monitored for one year after surgery. Taurine supplementation did not improve in-hospital morbidity, medical comorbidities during the first year, or mortality during the first year. Taurine supplementation lowered postoperative oxidative stress, as shown by lower urinary 8-hydroxy-2-deoxyguanosine levels (Generalized estimating equations (GEE) analysis average difference over time; regression coefficient (Beta): -0.54; 95% CI: -1.08--0.01; p = 0.04), blunted plasma malondialdehyde response (Beta: 1.58; 95% CI: 0.00-3.15; p = 0.05) and a trend towards lower lactate to pyruvate ratio (Beta: -1.10; 95% CI: -2.33-0.12; p = 0.08). We concluded that peri-operative taurine supplementation attenuated postoperative oxidative stress in elderly hip fracture patients, but did not improve postoperative morbidity and mortality.

No MeSH data available.


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Results of a dose finding on taurine dosage.
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ijms-16-12288-f003: Results of a dose finding on taurine dosage.

Mentions: A dose finding was performed before the start of the clinical trial to decide on the dosage to give. Based on a literature search, as described in the method section of the manuscript, it was known that dosages up to six grams a day could be safely administered. We did not find in the literature evidence for the rise and decline of plasma taurine levels in a regimen suitable for our clinical trial. Therefore, we performed a dose finding to decide on the dosage and regimen to give (Figure A1).


Effect of oral taurine on morbidity and mortality in elderly hip fracture patients: a randomized trial.

Van Stijn MF, Bruins AA, Vermeulen MA, Witlox J, Teerlink T, Schoorl MG, De Bandt JP, Twisk JW, Van Leeuwen PA, Houdijk AP - Int J Mol Sci (2015)

Results of a dose finding on taurine dosage.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490444&req=5

ijms-16-12288-f003: Results of a dose finding on taurine dosage.
Mentions: A dose finding was performed before the start of the clinical trial to decide on the dosage to give. Based on a literature search, as described in the method section of the manuscript, it was known that dosages up to six grams a day could be safely administered. We did not find in the literature evidence for the rise and decline of plasma taurine levels in a regimen suitable for our clinical trial. Therefore, we performed a dose finding to decide on the dosage and regimen to give (Figure A1).

Bottom Line: Taurine supplementation did not improve in-hospital morbidity, medical comorbidities during the first year, or mortality during the first year.Taurine supplementation lowered postoperative oxidative stress, as shown by lower urinary 8-hydroxy-2-deoxyguanosine levels (Generalized estimating equations (GEE) analysis average difference over time; regression coefficient (Beta): -0.54; 95% CI: -1.08--0.01; p = 0.04), blunted plasma malondialdehyde response (Beta: 1.58; 95% CI: 0.00-3.15; p = 0.05) and a trend towards lower lactate to pyruvate ratio (Beta: -1.10; 95% CI: -2.33-0.12; p = 0.08).We concluded that peri-operative taurine supplementation attenuated postoperative oxidative stress in elderly hip fracture patients, but did not improve postoperative morbidity and mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Medical Center Alkmaar, Wilhelminalaan 12, 1815 JD Alkmaar, The Netherlands. m.f.vanstijn@amc.uva.nl.

ABSTRACT
Hip fracture patients represent a large part of the elderly surgical population and face severe postoperative morbidity and excessive mortality compared to adult surgical hip fracture patients. Low antioxidant status and taurine deficiency is common in the elderly, and may negatively affect postoperative outcome. We hypothesized that taurine, an antioxidant, could improve clinical outcome in the elderly hip fracture patient. A double blind randomized, placebo controlled, clinical trial was conducted on elderly hip fracture patients. Supplementation started after admission and before surgery up to the sixth postoperative day. Markers of oxidative status were measured during hospitalization, and postoperative outcome was monitored for one year after surgery. Taurine supplementation did not improve in-hospital morbidity, medical comorbidities during the first year, or mortality during the first year. Taurine supplementation lowered postoperative oxidative stress, as shown by lower urinary 8-hydroxy-2-deoxyguanosine levels (Generalized estimating equations (GEE) analysis average difference over time; regression coefficient (Beta): -0.54; 95% CI: -1.08--0.01; p = 0.04), blunted plasma malondialdehyde response (Beta: 1.58; 95% CI: 0.00-3.15; p = 0.05) and a trend towards lower lactate to pyruvate ratio (Beta: -1.10; 95% CI: -2.33-0.12; p = 0.08). We concluded that peri-operative taurine supplementation attenuated postoperative oxidative stress in elderly hip fracture patients, but did not improve postoperative morbidity and mortality.

No MeSH data available.


Related in: MedlinePlus