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Effect of oral taurine on morbidity and mortality in elderly hip fracture patients: a randomized trial.

Van Stijn MF, Bruins AA, Vermeulen MA, Witlox J, Teerlink T, Schoorl MG, De Bandt JP, Twisk JW, Van Leeuwen PA, Houdijk AP - Int J Mol Sci (2015)

Bottom Line: Taurine supplementation did not improve in-hospital morbidity, medical comorbidities during the first year, or mortality during the first year.Taurine supplementation lowered postoperative oxidative stress, as shown by lower urinary 8-hydroxy-2-deoxyguanosine levels (Generalized estimating equations (GEE) analysis average difference over time; regression coefficient (Beta): -0.54; 95% CI: -1.08--0.01; p = 0.04), blunted plasma malondialdehyde response (Beta: 1.58; 95% CI: 0.00-3.15; p = 0.05) and a trend towards lower lactate to pyruvate ratio (Beta: -1.10; 95% CI: -2.33-0.12; p = 0.08).We concluded that peri-operative taurine supplementation attenuated postoperative oxidative stress in elderly hip fracture patients, but did not improve postoperative morbidity and mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Medical Center Alkmaar, Wilhelminalaan 12, 1815 JD Alkmaar, The Netherlands. m.f.vanstijn@amc.uva.nl.

ABSTRACT
Hip fracture patients represent a large part of the elderly surgical population and face severe postoperative morbidity and excessive mortality compared to adult surgical hip fracture patients. Low antioxidant status and taurine deficiency is common in the elderly, and may negatively affect postoperative outcome. We hypothesized that taurine, an antioxidant, could improve clinical outcome in the elderly hip fracture patient. A double blind randomized, placebo controlled, clinical trial was conducted on elderly hip fracture patients. Supplementation started after admission and before surgery up to the sixth postoperative day. Markers of oxidative status were measured during hospitalization, and postoperative outcome was monitored for one year after surgery. Taurine supplementation did not improve in-hospital morbidity, medical comorbidities during the first year, or mortality during the first year. Taurine supplementation lowered postoperative oxidative stress, as shown by lower urinary 8-hydroxy-2-deoxyguanosine levels (Generalized estimating equations (GEE) analysis average difference over time; regression coefficient (Beta): -0.54; 95% CI: -1.08--0.01; p = 0.04), blunted plasma malondialdehyde response (Beta: 1.58; 95% CI: 0.00-3.15; p = 0.05) and a trend towards lower lactate to pyruvate ratio (Beta: -1.10; 95% CI: -2.33-0.12; p = 0.08). We concluded that peri-operative taurine supplementation attenuated postoperative oxidative stress in elderly hip fracture patients, but did not improve postoperative morbidity and mortality.

No MeSH data available.


Related in: MedlinePlus

Flow Chart Inclusion. Kidney function is defined as creatinine clearance calculated with the Cockroft-Gault formula; miscellaneous patients: Three gastro-intestinal passage disorder, three language barrier, one hearing disability, thirteen secondary fractures, two had surgery in other hospital, eight cancer ± metastases, five primary total hip arthroplasty, six already participating in current study trial with contra lateral hip, three planned transfer to other hospital directly after surgery, one participating in other study trial.
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ijms-16-12288-f001: Flow Chart Inclusion. Kidney function is defined as creatinine clearance calculated with the Cockroft-Gault formula; miscellaneous patients: Three gastro-intestinal passage disorder, three language barrier, one hearing disability, thirteen secondary fractures, two had surgery in other hospital, eight cancer ± metastases, five primary total hip arthroplasty, six already participating in current study trial with contra lateral hip, three planned transfer to other hospital directly after surgery, one participating in other study trial.

Mentions: Between March 2008 and July 2010, 236 primary hip fracture patients aged 75 years or older entered the study. The flow chart of inclusion in the study is shown in Figure 1. Baseline patient characteristics of the taurine and placebo group are shown in Table 1, on an intention to treat analysis. Per protocol analysis of the baseline characteristics revealed no other differences (data not shown).


Effect of oral taurine on morbidity and mortality in elderly hip fracture patients: a randomized trial.

Van Stijn MF, Bruins AA, Vermeulen MA, Witlox J, Teerlink T, Schoorl MG, De Bandt JP, Twisk JW, Van Leeuwen PA, Houdijk AP - Int J Mol Sci (2015)

Flow Chart Inclusion. Kidney function is defined as creatinine clearance calculated with the Cockroft-Gault formula; miscellaneous patients: Three gastro-intestinal passage disorder, three language barrier, one hearing disability, thirteen secondary fractures, two had surgery in other hospital, eight cancer ± metastases, five primary total hip arthroplasty, six already participating in current study trial with contra lateral hip, three planned transfer to other hospital directly after surgery, one participating in other study trial.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490444&req=5

ijms-16-12288-f001: Flow Chart Inclusion. Kidney function is defined as creatinine clearance calculated with the Cockroft-Gault formula; miscellaneous patients: Three gastro-intestinal passage disorder, three language barrier, one hearing disability, thirteen secondary fractures, two had surgery in other hospital, eight cancer ± metastases, five primary total hip arthroplasty, six already participating in current study trial with contra lateral hip, three planned transfer to other hospital directly after surgery, one participating in other study trial.
Mentions: Between March 2008 and July 2010, 236 primary hip fracture patients aged 75 years or older entered the study. The flow chart of inclusion in the study is shown in Figure 1. Baseline patient characteristics of the taurine and placebo group are shown in Table 1, on an intention to treat analysis. Per protocol analysis of the baseline characteristics revealed no other differences (data not shown).

Bottom Line: Taurine supplementation did not improve in-hospital morbidity, medical comorbidities during the first year, or mortality during the first year.Taurine supplementation lowered postoperative oxidative stress, as shown by lower urinary 8-hydroxy-2-deoxyguanosine levels (Generalized estimating equations (GEE) analysis average difference over time; regression coefficient (Beta): -0.54; 95% CI: -1.08--0.01; p = 0.04), blunted plasma malondialdehyde response (Beta: 1.58; 95% CI: 0.00-3.15; p = 0.05) and a trend towards lower lactate to pyruvate ratio (Beta: -1.10; 95% CI: -2.33-0.12; p = 0.08).We concluded that peri-operative taurine supplementation attenuated postoperative oxidative stress in elderly hip fracture patients, but did not improve postoperative morbidity and mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Medical Center Alkmaar, Wilhelminalaan 12, 1815 JD Alkmaar, The Netherlands. m.f.vanstijn@amc.uva.nl.

ABSTRACT
Hip fracture patients represent a large part of the elderly surgical population and face severe postoperative morbidity and excessive mortality compared to adult surgical hip fracture patients. Low antioxidant status and taurine deficiency is common in the elderly, and may negatively affect postoperative outcome. We hypothesized that taurine, an antioxidant, could improve clinical outcome in the elderly hip fracture patient. A double blind randomized, placebo controlled, clinical trial was conducted on elderly hip fracture patients. Supplementation started after admission and before surgery up to the sixth postoperative day. Markers of oxidative status were measured during hospitalization, and postoperative outcome was monitored for one year after surgery. Taurine supplementation did not improve in-hospital morbidity, medical comorbidities during the first year, or mortality during the first year. Taurine supplementation lowered postoperative oxidative stress, as shown by lower urinary 8-hydroxy-2-deoxyguanosine levels (Generalized estimating equations (GEE) analysis average difference over time; regression coefficient (Beta): -0.54; 95% CI: -1.08--0.01; p = 0.04), blunted plasma malondialdehyde response (Beta: 1.58; 95% CI: 0.00-3.15; p = 0.05) and a trend towards lower lactate to pyruvate ratio (Beta: -1.10; 95% CI: -2.33-0.12; p = 0.08). We concluded that peri-operative taurine supplementation attenuated postoperative oxidative stress in elderly hip fracture patients, but did not improve postoperative morbidity and mortality.

No MeSH data available.


Related in: MedlinePlus