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Ecotoxicogenomic approaches for understanding molecular mechanisms of environmental chemical toxicity using aquatic invertebrate, Daphnia model organism.

Kim HJ, Koedrith P, Seo YR - Int J Mol Sci (2015)

Bottom Line: Due to the rapid advent in genomics technologies and attention to ecological risk assessment, the term "ecotoxicogenomics" has recently emerged to describe integration of omics studies (i.e., transcriptomics, proteomics, metabolomics, and epigenomics) into ecotoxicological fields.Ecotoxicogenomics is defined as study of an entire set of genes or proteins expression in ecological organisms to provide insight on environmental toxicity, offering benefit in ecological risk assessment.These approaches enable us to address adverse phenotypic outcomes linked to particular gene function(s) and mechanistic understanding of aquatic ecotoxicology as well as exploration of useful biomarkers.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environmental Medicine for Green Chemistry, Dongguk University Biomedi Campus 32, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-820, Korea. hd414@naver.com.

ABSTRACT
Due to the rapid advent in genomics technologies and attention to ecological risk assessment, the term "ecotoxicogenomics" has recently emerged to describe integration of omics studies (i.e., transcriptomics, proteomics, metabolomics, and epigenomics) into ecotoxicological fields. Ecotoxicogenomics is defined as study of an entire set of genes or proteins expression in ecological organisms to provide insight on environmental toxicity, offering benefit in ecological risk assessment. Indeed, Daphnia is a model species to study aquatic environmental toxicity designated in the Organization for Economic Co-operation and Development's toxicity test guideline and to investigate expression patterns using ecotoxicology-oriented genomics tools. Our main purpose is to demonstrate the potential utility of gene expression profiling in ecotoxicology by identifying novel biomarkers and relevant modes of toxicity in Daphnia magna. These approaches enable us to address adverse phenotypic outcomes linked to particular gene function(s) and mechanistic understanding of aquatic ecotoxicology as well as exploration of useful biomarkers. Furthermore, key challenges that currently face aquatic ecotoxicology (e.g., predicting toxicant responses among a broad spectrum of phytogenetic groups, predicting impact of temporal exposure on toxicant responses) necessitate the parallel use of other model organisms, both aquatic and terrestrial. By investigating gene expression profiling in an environmentally important organism, this provides viable support for the utility of ecotoxicogenomics.

No MeSH data available.


Related in: MedlinePlus

A scheme illustrating conceptual ecotoxicogenomics using Daphnia model. The thin arrows connect primary fields of study (in rectangles) to form interdisciplinary fields (in circles). The thick arrows indicate the tools or the knowledge that can be applied to integrated multidisplinary data sets, for instance: (1) ecological surveys; (2) genomic tools; (3) toxicity tests.
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ijms-16-12261-f001: A scheme illustrating conceptual ecotoxicogenomics using Daphnia model. The thin arrows connect primary fields of study (in rectangles) to form interdisciplinary fields (in circles). The thick arrows indicate the tools or the knowledge that can be applied to integrated multidisplinary data sets, for instance: (1) ecological surveys; (2) genomic tools; (3) toxicity tests.

Mentions: Recently, the term “ecotoxicogenomics” has been introduced [1,2,3,4,5] to describe the toxicogenomic context into ecotoxicological field (Figure 1) [6]. The toxicogenomic approach with the use of Daphnia magna as an aquatic invertebrate model advances our knowledge and understanding of ecotoxicity because current mechanism of chemical toxicity in invertebrates as well as potential biomarkers still need to be determined.


Ecotoxicogenomic approaches for understanding molecular mechanisms of environmental chemical toxicity using aquatic invertebrate, Daphnia model organism.

Kim HJ, Koedrith P, Seo YR - Int J Mol Sci (2015)

A scheme illustrating conceptual ecotoxicogenomics using Daphnia model. The thin arrows connect primary fields of study (in rectangles) to form interdisciplinary fields (in circles). The thick arrows indicate the tools or the knowledge that can be applied to integrated multidisplinary data sets, for instance: (1) ecological surveys; (2) genomic tools; (3) toxicity tests.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490443&req=5

ijms-16-12261-f001: A scheme illustrating conceptual ecotoxicogenomics using Daphnia model. The thin arrows connect primary fields of study (in rectangles) to form interdisciplinary fields (in circles). The thick arrows indicate the tools or the knowledge that can be applied to integrated multidisplinary data sets, for instance: (1) ecological surveys; (2) genomic tools; (3) toxicity tests.
Mentions: Recently, the term “ecotoxicogenomics” has been introduced [1,2,3,4,5] to describe the toxicogenomic context into ecotoxicological field (Figure 1) [6]. The toxicogenomic approach with the use of Daphnia magna as an aquatic invertebrate model advances our knowledge and understanding of ecotoxicity because current mechanism of chemical toxicity in invertebrates as well as potential biomarkers still need to be determined.

Bottom Line: Due to the rapid advent in genomics technologies and attention to ecological risk assessment, the term "ecotoxicogenomics" has recently emerged to describe integration of omics studies (i.e., transcriptomics, proteomics, metabolomics, and epigenomics) into ecotoxicological fields.Ecotoxicogenomics is defined as study of an entire set of genes or proteins expression in ecological organisms to provide insight on environmental toxicity, offering benefit in ecological risk assessment.These approaches enable us to address adverse phenotypic outcomes linked to particular gene function(s) and mechanistic understanding of aquatic ecotoxicology as well as exploration of useful biomarkers.

View Article: PubMed Central - PubMed

Affiliation: Institute of Environmental Medicine for Green Chemistry, Dongguk University Biomedi Campus 32, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-820, Korea. hd414@naver.com.

ABSTRACT
Due to the rapid advent in genomics technologies and attention to ecological risk assessment, the term "ecotoxicogenomics" has recently emerged to describe integration of omics studies (i.e., transcriptomics, proteomics, metabolomics, and epigenomics) into ecotoxicological fields. Ecotoxicogenomics is defined as study of an entire set of genes or proteins expression in ecological organisms to provide insight on environmental toxicity, offering benefit in ecological risk assessment. Indeed, Daphnia is a model species to study aquatic environmental toxicity designated in the Organization for Economic Co-operation and Development's toxicity test guideline and to investigate expression patterns using ecotoxicology-oriented genomics tools. Our main purpose is to demonstrate the potential utility of gene expression profiling in ecotoxicology by identifying novel biomarkers and relevant modes of toxicity in Daphnia magna. These approaches enable us to address adverse phenotypic outcomes linked to particular gene function(s) and mechanistic understanding of aquatic ecotoxicology as well as exploration of useful biomarkers. Furthermore, key challenges that currently face aquatic ecotoxicology (e.g., predicting toxicant responses among a broad spectrum of phytogenetic groups, predicting impact of temporal exposure on toxicant responses) necessitate the parallel use of other model organisms, both aquatic and terrestrial. By investigating gene expression profiling in an environmentally important organism, this provides viable support for the utility of ecotoxicogenomics.

No MeSH data available.


Related in: MedlinePlus