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Periostin expression and its prognostic value for colorectal cancer.

Li Z, Zhang X, Yang Y, Yang S, Dong Z, Du L, Wang L, Wang C - Int J Mol Sci (2015)

Bottom Line: The positive expression rate of POSTN protein (59.13%, 68/115) in colorectal cancers was significantly higher than that in adjacent normal colon mucosa (0.47%, 11/109).Further analysis showed that patients with advanced stage colorectal cancer and high POSTN expression levels had lower survival rates than those with early stage colorectal cancer and low POSTN expression levels.Overall, our results showed that POSTN played an important role in the progression of colorectal cancers.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan 250012, China. lizwlgs@yeah.net.

ABSTRACT
Integrin is important for cell growth, invasion and metastasis, which are frequently observed in malignant tumors. The periostin (POSTN) gene encodes the ligand for integrin, one of the key focal adhesion proteins contributing to the formation of a structural link between the extracellular matrix and integrins. High expression levels of the POSTN gene are correlated with numerous human malignancies. We examined POSTN protein in colorectal cancer specimens from 115 patients by strictly following up using immunohistochemistry. Cytoplasm immunohistochemical staining showed POSTN protein expression in colorectal cancers. The positive expression rate of POSTN protein (59.13%, 68/115) in colorectal cancers was significantly higher than that in adjacent normal colon mucosa (0.47%, 11/109). POSTN over-expression in colorectal cancers was positively correlated with tumor size, differentiation, lymph node metastasis, serosal invasion, clinical stage and five-year survival rates. Further analysis showed that patients with advanced stage colorectal cancer and high POSTN expression levels had lower survival rates than those with early stage colorectal cancer and low POSTN expression levels. Overall, our results showed that POSTN played an important role in the progression of colorectal cancers.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier analysis of five-year survival rates in 115 colorectal cancer patients according to (A) POSTN expression (p = 0.022); (B) Serosal invasion (SI) (p < 0.001); (C) Lymph nodes metastasis (p < 0.001); and (D) TNM stage (p < 0.001). Vertical bars represent censored patients.
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ijms-16-12108-f002: Kaplan-Meier analysis of five-year survival rates in 115 colorectal cancer patients according to (A) POSTN expression (p = 0.022); (B) Serosal invasion (SI) (p < 0.001); (C) Lymph nodes metastasis (p < 0.001); and (D) TNM stage (p < 0.001). Vertical bars represent censored patients.

Mentions: To further demonstrate the importance of high POSTN expression in the prognosis of colorectal cancer progression, we analyzed the correlations between POSTN expression and factors associated with the aggressiveness of colorectal cancer. The cumulative 5-year overall survival rate was 59.13%, and the 5-year cumulative probability of survival for patients with high levels of POSTN expression (45.6%) was significantly lower than that for patients with low levels of POSTN expression (78.7%) (p = 0.001, Figure 2A). In addition, the results of Kaplan-Meier analysis and log-rank test showed that survival time was also associated with serosal invasion (p = 0.014, Figure 2B), lymph nodes metastasis (p < 0.001, Figure 2C) and tumor stage (p = 0.01, Figure 2D).


Periostin expression and its prognostic value for colorectal cancer.

Li Z, Zhang X, Yang Y, Yang S, Dong Z, Du L, Wang L, Wang C - Int J Mol Sci (2015)

Kaplan-Meier analysis of five-year survival rates in 115 colorectal cancer patients according to (A) POSTN expression (p = 0.022); (B) Serosal invasion (SI) (p < 0.001); (C) Lymph nodes metastasis (p < 0.001); and (D) TNM stage (p < 0.001). Vertical bars represent censored patients.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4490432&req=5

ijms-16-12108-f002: Kaplan-Meier analysis of five-year survival rates in 115 colorectal cancer patients according to (A) POSTN expression (p = 0.022); (B) Serosal invasion (SI) (p < 0.001); (C) Lymph nodes metastasis (p < 0.001); and (D) TNM stage (p < 0.001). Vertical bars represent censored patients.
Mentions: To further demonstrate the importance of high POSTN expression in the prognosis of colorectal cancer progression, we analyzed the correlations between POSTN expression and factors associated with the aggressiveness of colorectal cancer. The cumulative 5-year overall survival rate was 59.13%, and the 5-year cumulative probability of survival for patients with high levels of POSTN expression (45.6%) was significantly lower than that for patients with low levels of POSTN expression (78.7%) (p = 0.001, Figure 2A). In addition, the results of Kaplan-Meier analysis and log-rank test showed that survival time was also associated with serosal invasion (p = 0.014, Figure 2B), lymph nodes metastasis (p < 0.001, Figure 2C) and tumor stage (p = 0.01, Figure 2D).

Bottom Line: The positive expression rate of POSTN protein (59.13%, 68/115) in colorectal cancers was significantly higher than that in adjacent normal colon mucosa (0.47%, 11/109).Further analysis showed that patients with advanced stage colorectal cancer and high POSTN expression levels had lower survival rates than those with early stage colorectal cancer and low POSTN expression levels.Overall, our results showed that POSTN played an important role in the progression of colorectal cancers.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan 250012, China. lizwlgs@yeah.net.

ABSTRACT
Integrin is important for cell growth, invasion and metastasis, which are frequently observed in malignant tumors. The periostin (POSTN) gene encodes the ligand for integrin, one of the key focal adhesion proteins contributing to the formation of a structural link between the extracellular matrix and integrins. High expression levels of the POSTN gene are correlated with numerous human malignancies. We examined POSTN protein in colorectal cancer specimens from 115 patients by strictly following up using immunohistochemistry. Cytoplasm immunohistochemical staining showed POSTN protein expression in colorectal cancers. The positive expression rate of POSTN protein (59.13%, 68/115) in colorectal cancers was significantly higher than that in adjacent normal colon mucosa (0.47%, 11/109). POSTN over-expression in colorectal cancers was positively correlated with tumor size, differentiation, lymph node metastasis, serosal invasion, clinical stage and five-year survival rates. Further analysis showed that patients with advanced stage colorectal cancer and high POSTN expression levels had lower survival rates than those with early stage colorectal cancer and low POSTN expression levels. Overall, our results showed that POSTN played an important role in the progression of colorectal cancers.

No MeSH data available.


Related in: MedlinePlus