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Lack of Association between the TSPAN18 Gene and Schizophrenia Based on New Data from Han Chinese and a Meta-Analysis.

Zhang B, Li DX, Lu N, Fan QR, Li WH, Feng ZF - Int J Mol Sci (2015)

Bottom Line: Furthermore, a genome-wide association study (GWAS) identified TSPAN18 as a possible susceptibility gene for SCZ.To validate these findings and reveal the effects of different inheritance models, seven single nucleotide polymorphisms (SNPs) of the TSPAN18 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent via the SNPscan method.We observed genotypes and allele distributions of TSPAN18 gene did not show any significant associations in the Han Chinese population based on our experimental and meta-analytical results.

View Article: PubMed Central - PubMed

Affiliation: College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. zhangbao_814@mail.xjtu.edu.cn.

ABSTRACT
Tetraspanin-18 (TSPAN18) potentially plays a role in the calcium signaling that is associated with dopamine-induced cortical neuron apoptosis and is considered to be an important mechanism in the pathogenesis of schizophrenia (SCZ). Furthermore, a genome-wide association study (GWAS) identified TSPAN18 as a possible susceptibility gene for SCZ. To validate these findings and reveal the effects of different inheritance models, seven single nucleotide polymorphisms (SNPs) of the TSPAN18 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent via the SNPscan method. Single SNP, genotype, and association analyses with different models (i.e., additive, dominant, and recessive models) were performed, and the published datasets (2062 cases and 2053 controls) were combined with our results to determine the inheritance effects of the SNPs on SCZ. We observed genotypes and allele distributions of TSPAN18 gene did not show any significant associations in the Han Chinese population based on our experimental and meta-analytical results. Our findings indicate that the TSPAN18 gene is unlikely to be a major susceptibility gene for schizophrenia in Han Chinese.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the TSPAN18 rs11038172 polymorphism and Schizophrenia (SCZ) risk in the overall population.
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ijms-16-11864-f002: Forest plot of the TSPAN18 rs11038172 polymorphism and Schizophrenia (SCZ) risk in the overall population.

Mentions: For the meta-analysis, we combined and analyzed the data from two previous studies with those from the current study for totals of 2505 cases and 2681 controls [7,8]. A statistical summary of the meta-analysis of rs11038172 is shown in Figure 2.


Lack of Association between the TSPAN18 Gene and Schizophrenia Based on New Data from Han Chinese and a Meta-Analysis.

Zhang B, Li DX, Lu N, Fan QR, Li WH, Feng ZF - Int J Mol Sci (2015)

Forest plot of the TSPAN18 rs11038172 polymorphism and Schizophrenia (SCZ) risk in the overall population.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490419&req=5

ijms-16-11864-f002: Forest plot of the TSPAN18 rs11038172 polymorphism and Schizophrenia (SCZ) risk in the overall population.
Mentions: For the meta-analysis, we combined and analyzed the data from two previous studies with those from the current study for totals of 2505 cases and 2681 controls [7,8]. A statistical summary of the meta-analysis of rs11038172 is shown in Figure 2.

Bottom Line: Furthermore, a genome-wide association study (GWAS) identified TSPAN18 as a possible susceptibility gene for SCZ.To validate these findings and reveal the effects of different inheritance models, seven single nucleotide polymorphisms (SNPs) of the TSPAN18 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent via the SNPscan method.We observed genotypes and allele distributions of TSPAN18 gene did not show any significant associations in the Han Chinese population based on our experimental and meta-analytical results.

View Article: PubMed Central - PubMed

Affiliation: College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. zhangbao_814@mail.xjtu.edu.cn.

ABSTRACT
Tetraspanin-18 (TSPAN18) potentially plays a role in the calcium signaling that is associated with dopamine-induced cortical neuron apoptosis and is considered to be an important mechanism in the pathogenesis of schizophrenia (SCZ). Furthermore, a genome-wide association study (GWAS) identified TSPAN18 as a possible susceptibility gene for SCZ. To validate these findings and reveal the effects of different inheritance models, seven single nucleotide polymorphisms (SNPs) of the TSPAN18 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent via the SNPscan method. Single SNP, genotype, and association analyses with different models (i.e., additive, dominant, and recessive models) were performed, and the published datasets (2062 cases and 2053 controls) were combined with our results to determine the inheritance effects of the SNPs on SCZ. We observed genotypes and allele distributions of TSPAN18 gene did not show any significant associations in the Han Chinese population based on our experimental and meta-analytical results. Our findings indicate that the TSPAN18 gene is unlikely to be a major susceptibility gene for schizophrenia in Han Chinese.

No MeSH data available.


Related in: MedlinePlus