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Lack of Association between the TSPAN18 Gene and Schizophrenia Based on New Data from Han Chinese and a Meta-Analysis.

Zhang B, Li DX, Lu N, Fan QR, Li WH, Feng ZF - Int J Mol Sci (2015)

Bottom Line: Furthermore, a genome-wide association study (GWAS) identified TSPAN18 as a possible susceptibility gene for SCZ.To validate these findings and reveal the effects of different inheritance models, seven single nucleotide polymorphisms (SNPs) of the TSPAN18 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent via the SNPscan method.We observed genotypes and allele distributions of TSPAN18 gene did not show any significant associations in the Han Chinese population based on our experimental and meta-analytical results.

View Article: PubMed Central - PubMed

Affiliation: College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. zhangbao_814@mail.xjtu.edu.cn.

ABSTRACT
Tetraspanin-18 (TSPAN18) potentially plays a role in the calcium signaling that is associated with dopamine-induced cortical neuron apoptosis and is considered to be an important mechanism in the pathogenesis of schizophrenia (SCZ). Furthermore, a genome-wide association study (GWAS) identified TSPAN18 as a possible susceptibility gene for SCZ. To validate these findings and reveal the effects of different inheritance models, seven single nucleotide polymorphisms (SNPs) of the TSPAN18 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent via the SNPscan method. Single SNP, genotype, and association analyses with different models (i.e., additive, dominant, and recessive models) were performed, and the published datasets (2062 cases and 2053 controls) were combined with our results to determine the inheritance effects of the SNPs on SCZ. We observed genotypes and allele distributions of TSPAN18 gene did not show any significant associations in the Han Chinese population based on our experimental and meta-analytical results. Our findings indicate that the TSPAN18 gene is unlikely to be a major susceptibility gene for schizophrenia in Han Chinese.

No MeSH data available.


Related in: MedlinePlus

Linkage disequilibrium (LD) plot of 7 single nucleotide polymorphisms (SNPs) of the TSPAN18 (Tetraspanin-8) gene. The values in the squares indicate the pair-wise calculations of R2. The white squares with “0” indicate R2 = 0 (i.e., no LD between a pair of SNPs).
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ijms-16-11864-f001: Linkage disequilibrium (LD) plot of 7 single nucleotide polymorphisms (SNPs) of the TSPAN18 (Tetraspanin-8) gene. The values in the squares indicate the pair-wise calculations of R2. The white squares with “0” indicate R2 = 0 (i.e., no LD between a pair of SNPs).

Mentions: Seven SNPs in the TSPAN18 gene were genotyped in 443 SCZ cases and 628 controls. No significant deviations from Hardy–Weinberg equilibrium (HWE) were found in either group. The frequencies of the alleles and genotypes of the seven SNPs are shown in Table 1. When all of the samples were considered, the allele frequencies and genotype association analysis for the patients with SCZ did not significantly differ from those of the control group. After the linkage disequilibrium (LD) blocks were created, we found that seven SNPs exhibited very low R2 values (Figure 1), indicating that the calculations of the haplotype frequencies were not required.


Lack of Association between the TSPAN18 Gene and Schizophrenia Based on New Data from Han Chinese and a Meta-Analysis.

Zhang B, Li DX, Lu N, Fan QR, Li WH, Feng ZF - Int J Mol Sci (2015)

Linkage disequilibrium (LD) plot of 7 single nucleotide polymorphisms (SNPs) of the TSPAN18 (Tetraspanin-8) gene. The values in the squares indicate the pair-wise calculations of R2. The white squares with “0” indicate R2 = 0 (i.e., no LD between a pair of SNPs).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490419&req=5

ijms-16-11864-f001: Linkage disequilibrium (LD) plot of 7 single nucleotide polymorphisms (SNPs) of the TSPAN18 (Tetraspanin-8) gene. The values in the squares indicate the pair-wise calculations of R2. The white squares with “0” indicate R2 = 0 (i.e., no LD between a pair of SNPs).
Mentions: Seven SNPs in the TSPAN18 gene were genotyped in 443 SCZ cases and 628 controls. No significant deviations from Hardy–Weinberg equilibrium (HWE) were found in either group. The frequencies of the alleles and genotypes of the seven SNPs are shown in Table 1. When all of the samples were considered, the allele frequencies and genotype association analysis for the patients with SCZ did not significantly differ from those of the control group. After the linkage disequilibrium (LD) blocks were created, we found that seven SNPs exhibited very low R2 values (Figure 1), indicating that the calculations of the haplotype frequencies were not required.

Bottom Line: Furthermore, a genome-wide association study (GWAS) identified TSPAN18 as a possible susceptibility gene for SCZ.To validate these findings and reveal the effects of different inheritance models, seven single nucleotide polymorphisms (SNPs) of the TSPAN18 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent via the SNPscan method.We observed genotypes and allele distributions of TSPAN18 gene did not show any significant associations in the Han Chinese population based on our experimental and meta-analytical results.

View Article: PubMed Central - PubMed

Affiliation: College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. zhangbao_814@mail.xjtu.edu.cn.

ABSTRACT
Tetraspanin-18 (TSPAN18) potentially plays a role in the calcium signaling that is associated with dopamine-induced cortical neuron apoptosis and is considered to be an important mechanism in the pathogenesis of schizophrenia (SCZ). Furthermore, a genome-wide association study (GWAS) identified TSPAN18 as a possible susceptibility gene for SCZ. To validate these findings and reveal the effects of different inheritance models, seven single nucleotide polymorphisms (SNPs) of the TSPAN18 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent via the SNPscan method. Single SNP, genotype, and association analyses with different models (i.e., additive, dominant, and recessive models) were performed, and the published datasets (2062 cases and 2053 controls) were combined with our results to determine the inheritance effects of the SNPs on SCZ. We observed genotypes and allele distributions of TSPAN18 gene did not show any significant associations in the Han Chinese population based on our experimental and meta-analytical results. Our findings indicate that the TSPAN18 gene is unlikely to be a major susceptibility gene for schizophrenia in Han Chinese.

No MeSH data available.


Related in: MedlinePlus