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Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects.

Fan SJ, Yang BY, Zhi XY, He M, Wang D, Wang YX, Wang YN, Wei J, Zheng QM, Sun GF - Int J Mol Sci (2015)

Bottom Line: However, the results are still controversial.The following meta-analysis confirmed our case-control results.Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings.

View Article: PubMed Central - PubMed

Affiliation: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110013, China. fanfan0721ykl@163.com.

ABSTRACT
Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of the study selection process in this meta-analysis.
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ijms-16-11849-f001: Flow diagram of the study selection process in this meta-analysis.

Mentions: Figure 1 details the process of selecting and excluding articles. A total of nine publications [4,5,6,7,8,9,10,11,12] with 13 studies (combining the current study) comprising 5431 cases and 24,896 controls were included in the meta-analysis. Characteristics and genotype distributions of these studies are summarized in Table S1 and Table 3, respectively.


Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects.

Fan SJ, Yang BY, Zhi XY, He M, Wang D, Wang YX, Wang YN, Wei J, Zheng QM, Sun GF - Int J Mol Sci (2015)

Flow diagram of the study selection process in this meta-analysis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490418&req=5

ijms-16-11849-f001: Flow diagram of the study selection process in this meta-analysis.
Mentions: Figure 1 details the process of selecting and excluding articles. A total of nine publications [4,5,6,7,8,9,10,11,12] with 13 studies (combining the current study) comprising 5431 cases and 24,896 controls were included in the meta-analysis. Characteristics and genotype distributions of these studies are summarized in Table S1 and Table 3, respectively.

Bottom Line: However, the results are still controversial.The following meta-analysis confirmed our case-control results.Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings.

View Article: PubMed Central - PubMed

Affiliation: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110013, China. fanfan0721ykl@163.com.

ABSTRACT
Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings.

No MeSH data available.


Related in: MedlinePlus