Limits...
Longevity factor klotho and chronic psychological stress.

Prather AA, Epel ES, Arenander J, Broestl L, Garay BI, Wang D, Dubal DB - Transl Psychiatry (2015)

Bottom Line: We found that women under high chronic stress displayed significantly lower levels of the longevity hormone klotho compared with low-stress controls (t(176) = 2.92, P = 0.004; d = 0.44), and the decrease among those under high stress was age-dependent.In addition, high-stress caregivers who reported more depressive symptoms displayed even lower klotho levels compared with low-stress participants.These findings provide the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting stress, depression and risk for accelerated disease development.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.

ABSTRACT
Chronic psychological stress is associated with accelerated aging and premature morbidity and mortality; however, the biology linking chronic psychological stress and its maladaptive effects remains largely unknown. Klotho is a pleiotropic hormone that regulates the aging process and promotes better brain and body health. Whether klotho is linked to psychosocial stress or its negative impact in humans has not been investigated. To address this gap, we recruited 178 healthy women who were either chronically high-stress maternal caregivers for a child with autism spectrum disorder (n = 90) or low-stress control mothers of a typically developing child (n = 88). We found that women under high chronic stress displayed significantly lower levels of the longevity hormone klotho compared with low-stress controls (t(176) = 2.92, P = 0.004; d = 0.44), and the decrease among those under high stress was age-dependent. In addition, high-stress caregivers who reported more depressive symptoms displayed even lower klotho levels compared with low-stress participants. These findings provide the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting stress, depression and risk for accelerated disease development. Furthermore, these findings have important implications for understanding the plasticity of the aging process and may represent a therapeutic target for mitigating the deleterious effects of chronic psychological stress on health and well-being.

No MeSH data available.


Related in: MedlinePlus

Klotho levels show age-related decline in young women under high, chronic stress. Klotho levels decreased with increasing age in chronic, high-stress caregivers (linear regression B=−0.26, P=0.014; R2=0.06), but not low-stress women (B=0.01, P=0.934; R2=0.00). This association remained significant after accounting for body mass index (BMI; B=−0.26, P=0.016; ΔR2=0.05). Analyses were carried out on log10-transformed klotho values.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4490291&req=5

fig2: Klotho levels show age-related decline in young women under high, chronic stress. Klotho levels decreased with increasing age in chronic, high-stress caregivers (linear regression B=−0.26, P=0.014; R2=0.06), but not low-stress women (B=0.01, P=0.934; R2=0.00). This association remained significant after accounting for body mass index (BMI; B=−0.26, P=0.016; ΔR2=0.05). Analyses were carried out on log10-transformed klotho values.

Mentions: As chronic psychological stress is associated with accelerated biological aging,44, 46, 47 we explored whether age-related decline in klotho occurs more rapidly under high stress. We found that high-stress women (B=−0.26, P=0.014; R2=0.06), but not low-stress controls (B=0.01, P=0.934; R2=0.00), showed a significant age-related decline in klotho levels (Figure 2). The association between low klotho and age among high-stress caregivers remained significant after adjusting for BMI (high stress: B=−0.26, P=0.016; ΔR2=0.05; low stress: B=0.03, P=0.815; ΔR2=0.00). There was a trend for a significant group difference in these associations (Z=1.87, P=0.06). Thus, even among young otherwise healthy women, those under chronic psychological stress, but not under lower levels of stress, showed accelerated age-dependent decline in klotho.


Longevity factor klotho and chronic psychological stress.

Prather AA, Epel ES, Arenander J, Broestl L, Garay BI, Wang D, Dubal DB - Transl Psychiatry (2015)

Klotho levels show age-related decline in young women under high, chronic stress. Klotho levels decreased with increasing age in chronic, high-stress caregivers (linear regression B=−0.26, P=0.014; R2=0.06), but not low-stress women (B=0.01, P=0.934; R2=0.00). This association remained significant after accounting for body mass index (BMI; B=−0.26, P=0.016; ΔR2=0.05). Analyses were carried out on log10-transformed klotho values.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490291&req=5

fig2: Klotho levels show age-related decline in young women under high, chronic stress. Klotho levels decreased with increasing age in chronic, high-stress caregivers (linear regression B=−0.26, P=0.014; R2=0.06), but not low-stress women (B=0.01, P=0.934; R2=0.00). This association remained significant after accounting for body mass index (BMI; B=−0.26, P=0.016; ΔR2=0.05). Analyses were carried out on log10-transformed klotho values.
Mentions: As chronic psychological stress is associated with accelerated biological aging,44, 46, 47 we explored whether age-related decline in klotho occurs more rapidly under high stress. We found that high-stress women (B=−0.26, P=0.014; R2=0.06), but not low-stress controls (B=0.01, P=0.934; R2=0.00), showed a significant age-related decline in klotho levels (Figure 2). The association between low klotho and age among high-stress caregivers remained significant after adjusting for BMI (high stress: B=−0.26, P=0.016; ΔR2=0.05; low stress: B=0.03, P=0.815; ΔR2=0.00). There was a trend for a significant group difference in these associations (Z=1.87, P=0.06). Thus, even among young otherwise healthy women, those under chronic psychological stress, but not under lower levels of stress, showed accelerated age-dependent decline in klotho.

Bottom Line: We found that women under high chronic stress displayed significantly lower levels of the longevity hormone klotho compared with low-stress controls (t(176) = 2.92, P = 0.004; d = 0.44), and the decrease among those under high stress was age-dependent.In addition, high-stress caregivers who reported more depressive symptoms displayed even lower klotho levels compared with low-stress participants.These findings provide the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting stress, depression and risk for accelerated disease development.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.

ABSTRACT
Chronic psychological stress is associated with accelerated aging and premature morbidity and mortality; however, the biology linking chronic psychological stress and its maladaptive effects remains largely unknown. Klotho is a pleiotropic hormone that regulates the aging process and promotes better brain and body health. Whether klotho is linked to psychosocial stress or its negative impact in humans has not been investigated. To address this gap, we recruited 178 healthy women who were either chronically high-stress maternal caregivers for a child with autism spectrum disorder (n = 90) or low-stress control mothers of a typically developing child (n = 88). We found that women under high chronic stress displayed significantly lower levels of the longevity hormone klotho compared with low-stress controls (t(176) = 2.92, P = 0.004; d = 0.44), and the decrease among those under high stress was age-dependent. In addition, high-stress caregivers who reported more depressive symptoms displayed even lower klotho levels compared with low-stress participants. These findings provide the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting stress, depression and risk for accelerated disease development. Furthermore, these findings have important implications for understanding the plasticity of the aging process and may represent a therapeutic target for mitigating the deleterious effects of chronic psychological stress on health and well-being.

No MeSH data available.


Related in: MedlinePlus