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Longevity factor klotho and chronic psychological stress.

Prather AA, Epel ES, Arenander J, Broestl L, Garay BI, Wang D, Dubal DB - Transl Psychiatry (2015)

Bottom Line: We found that women under high chronic stress displayed significantly lower levels of the longevity hormone klotho compared with low-stress controls (t(176) = 2.92, P = 0.004; d = 0.44), and the decrease among those under high stress was age-dependent.In addition, high-stress caregivers who reported more depressive symptoms displayed even lower klotho levels compared with low-stress participants.These findings provide the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting stress, depression and risk for accelerated disease development.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.

ABSTRACT
Chronic psychological stress is associated with accelerated aging and premature morbidity and mortality; however, the biology linking chronic psychological stress and its maladaptive effects remains largely unknown. Klotho is a pleiotropic hormone that regulates the aging process and promotes better brain and body health. Whether klotho is linked to psychosocial stress or its negative impact in humans has not been investigated. To address this gap, we recruited 178 healthy women who were either chronically high-stress maternal caregivers for a child with autism spectrum disorder (n = 90) or low-stress control mothers of a typically developing child (n = 88). We found that women under high chronic stress displayed significantly lower levels of the longevity hormone klotho compared with low-stress controls (t(176) = 2.92, P = 0.004; d = 0.44), and the decrease among those under high stress was age-dependent. In addition, high-stress caregivers who reported more depressive symptoms displayed even lower klotho levels compared with low-stress participants. These findings provide the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting stress, depression and risk for accelerated disease development. Furthermore, these findings have important implications for understanding the plasticity of the aging process and may represent a therapeutic target for mitigating the deleterious effects of chronic psychological stress on health and well-being.

No MeSH data available.


Related in: MedlinePlus

Klotho levels are lower in young women under chronic, high stress. Fasting morning serum klotho levels of high-stress maternal caregiver women (n=90) and low-stress controls (n=88) are shown. Analysis of covariance (ANCOVA) analyses revealed that high-stress women showed lower levels of klotho compared with low-stress controls (t(176)=2.92, **P=0.004). These differences remained significant after accounting for effects of age and body mass index (BMI; F(1, 173)=7.27, P=0.008). Analyses were carried out on log10-transformed klotho values. Data are means±s.e.m.
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fig1: Klotho levels are lower in young women under chronic, high stress. Fasting morning serum klotho levels of high-stress maternal caregiver women (n=90) and low-stress controls (n=88) are shown. Analysis of covariance (ANCOVA) analyses revealed that high-stress women showed lower levels of klotho compared with low-stress controls (t(176)=2.92, **P=0.004). These differences remained significant after accounting for effects of age and body mass index (BMI; F(1, 173)=7.27, P=0.008). Analyses were carried out on log10-transformed klotho values. Data are means±s.e.m.

Mentions: We hypothesized that high stress would be associated with lower levels of circulating klotho. We found that women with high chronic stress displayed lower serum levels (M=836.0 pg ml−1, s.d.=327.7) of klotho compared with low-stress controls (M=949.0 pg ml−1, s.d.=311.8) by 12% (t(176)=2.92, P=0.004; d=0.44). This difference remained statistically significant after adjusting separately for age (P=0.006; d=0.42), BMI (P=0.006; d=0.42), and after adjusting for these factors together (P=0.008; d=0.41; adjusted means displayed in Figure 1). Higher levels of perceived stress were statistically related to lower levels of klotho in bivariate (r=−0.11, P=0.04) but not age-adjusted (r=−0.10, P=0.17) analyses.


Longevity factor klotho and chronic psychological stress.

Prather AA, Epel ES, Arenander J, Broestl L, Garay BI, Wang D, Dubal DB - Transl Psychiatry (2015)

Klotho levels are lower in young women under chronic, high stress. Fasting morning serum klotho levels of high-stress maternal caregiver women (n=90) and low-stress controls (n=88) are shown. Analysis of covariance (ANCOVA) analyses revealed that high-stress women showed lower levels of klotho compared with low-stress controls (t(176)=2.92, **P=0.004). These differences remained significant after accounting for effects of age and body mass index (BMI; F(1, 173)=7.27, P=0.008). Analyses were carried out on log10-transformed klotho values. Data are means±s.e.m.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490291&req=5

fig1: Klotho levels are lower in young women under chronic, high stress. Fasting morning serum klotho levels of high-stress maternal caregiver women (n=90) and low-stress controls (n=88) are shown. Analysis of covariance (ANCOVA) analyses revealed that high-stress women showed lower levels of klotho compared with low-stress controls (t(176)=2.92, **P=0.004). These differences remained significant after accounting for effects of age and body mass index (BMI; F(1, 173)=7.27, P=0.008). Analyses were carried out on log10-transformed klotho values. Data are means±s.e.m.
Mentions: We hypothesized that high stress would be associated with lower levels of circulating klotho. We found that women with high chronic stress displayed lower serum levels (M=836.0 pg ml−1, s.d.=327.7) of klotho compared with low-stress controls (M=949.0 pg ml−1, s.d.=311.8) by 12% (t(176)=2.92, P=0.004; d=0.44). This difference remained statistically significant after adjusting separately for age (P=0.006; d=0.42), BMI (P=0.006; d=0.42), and after adjusting for these factors together (P=0.008; d=0.41; adjusted means displayed in Figure 1). Higher levels of perceived stress were statistically related to lower levels of klotho in bivariate (r=−0.11, P=0.04) but not age-adjusted (r=−0.10, P=0.17) analyses.

Bottom Line: We found that women under high chronic stress displayed significantly lower levels of the longevity hormone klotho compared with low-stress controls (t(176) = 2.92, P = 0.004; d = 0.44), and the decrease among those under high stress was age-dependent.In addition, high-stress caregivers who reported more depressive symptoms displayed even lower klotho levels compared with low-stress participants.These findings provide the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting stress, depression and risk for accelerated disease development.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.

ABSTRACT
Chronic psychological stress is associated with accelerated aging and premature morbidity and mortality; however, the biology linking chronic psychological stress and its maladaptive effects remains largely unknown. Klotho is a pleiotropic hormone that regulates the aging process and promotes better brain and body health. Whether klotho is linked to psychosocial stress or its negative impact in humans has not been investigated. To address this gap, we recruited 178 healthy women who were either chronically high-stress maternal caregivers for a child with autism spectrum disorder (n = 90) or low-stress control mothers of a typically developing child (n = 88). We found that women under high chronic stress displayed significantly lower levels of the longevity hormone klotho compared with low-stress controls (t(176) = 2.92, P = 0.004; d = 0.44), and the decrease among those under high stress was age-dependent. In addition, high-stress caregivers who reported more depressive symptoms displayed even lower klotho levels compared with low-stress participants. These findings provide the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting stress, depression and risk for accelerated disease development. Furthermore, these findings have important implications for understanding the plasticity of the aging process and may represent a therapeutic target for mitigating the deleterious effects of chronic psychological stress on health and well-being.

No MeSH data available.


Related in: MedlinePlus