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Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation.

Smucny J, Stevens KE, Olincy A, Tregellas JR - Transl Psychiatry (2015)

Bottom Line: We show that drug effects on the P20-N40 are highly predictive of human effects across similar dose ranges.Furthermore, mental status (for example, anesthetized vs alert) does not appear to diminish the predictive capacity of these recordings.We then discuss hypothesized neuropharmacologic mechanisms that may underlie gating effects for each drug studied.

View Article: PubMed Central - PubMed

Affiliation: 1] Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA [2] Research Service, Denver VA Medical Center, Denver, CO, USA [3] Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

ABSTRACT
Impaired gating of the auditory evoked P50 potential is one of the most pharmacologically well-characterized features of schizophrenia. This deficit is most commonly modeled in rodents by implanted electrode recordings from the hippocampus of the rodent analog of the P50, the P20-N40. The validity and effectiveness of this tool, however, has not been systematically reviewed. Here, we summarize findings from studies that have examined the effects of pharmacologic modulation on gating of the rodent hippocampal P20-N40 and the human P50. We show that drug effects on the P20-N40 are highly predictive of human effects across similar dose ranges. Furthermore, mental status (for example, anesthetized vs alert) does not appear to diminish the predictive capacity of these recordings. We then discuss hypothesized neuropharmacologic mechanisms that may underlie gating effects for each drug studied. Overall, this review supports continued use of hippocampal P20-N40 gating as a translational tool for schizophrenia research.

No MeSH data available.


Related in: MedlinePlus

Location of CA3 electrodes in the mouse hippocampus for recording P20/N40 evoked potentials. Figure adapted from Guo et al.24 ERP, event-related potential.
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fig3: Location of CA3 electrodes in the mouse hippocampus for recording P20/N40 evoked potentials. Figure adapted from Guo et al.24 ERP, event-related potential.

Mentions: The results of this study became the basis for using depth electrode recordings from the hippocampus (CA3 region, Figure 3) to study auditory gating in mouse and rat models of schizophrenia. Hippocampal localization of gating and its schizophrenia-associated deficit in humans has since been supported in studies using implanted electrodes from epileptic patients21 and noninvasive techniques such as electroencephalography combined with functional magnetic resonance imaging.22, 23


Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation.

Smucny J, Stevens KE, Olincy A, Tregellas JR - Transl Psychiatry (2015)

Location of CA3 electrodes in the mouse hippocampus for recording P20/N40 evoked potentials. Figure adapted from Guo et al.24 ERP, event-related potential.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490287&req=5

fig3: Location of CA3 electrodes in the mouse hippocampus for recording P20/N40 evoked potentials. Figure adapted from Guo et al.24 ERP, event-related potential.
Mentions: The results of this study became the basis for using depth electrode recordings from the hippocampus (CA3 region, Figure 3) to study auditory gating in mouse and rat models of schizophrenia. Hippocampal localization of gating and its schizophrenia-associated deficit in humans has since been supported in studies using implanted electrodes from epileptic patients21 and noninvasive techniques such as electroencephalography combined with functional magnetic resonance imaging.22, 23

Bottom Line: We show that drug effects on the P20-N40 are highly predictive of human effects across similar dose ranges.Furthermore, mental status (for example, anesthetized vs alert) does not appear to diminish the predictive capacity of these recordings.We then discuss hypothesized neuropharmacologic mechanisms that may underlie gating effects for each drug studied.

View Article: PubMed Central - PubMed

Affiliation: 1] Neuroscience Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA [2] Research Service, Denver VA Medical Center, Denver, CO, USA [3] Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

ABSTRACT
Impaired gating of the auditory evoked P50 potential is one of the most pharmacologically well-characterized features of schizophrenia. This deficit is most commonly modeled in rodents by implanted electrode recordings from the hippocampus of the rodent analog of the P50, the P20-N40. The validity and effectiveness of this tool, however, has not been systematically reviewed. Here, we summarize findings from studies that have examined the effects of pharmacologic modulation on gating of the rodent hippocampal P20-N40 and the human P50. We show that drug effects on the P20-N40 are highly predictive of human effects across similar dose ranges. Furthermore, mental status (for example, anesthetized vs alert) does not appear to diminish the predictive capacity of these recordings. We then discuss hypothesized neuropharmacologic mechanisms that may underlie gating effects for each drug studied. Overall, this review supports continued use of hippocampal P20-N40 gating as a translational tool for schizophrenia research.

No MeSH data available.


Related in: MedlinePlus