Limits...
Telomere length is associated with oppositional defiant behavior and maternal clinical depression in Latino preschool children.

Wojcicki JM, Heyman MB, Elwan D, Shiboski S, Lin J, Blackburn E, Epel E - Transl Psychiatry (2015)

Bottom Line: Thus, exposure to maternal clinical depression (versus depressive symptoms) in early childhood was associated with deleterious consequences on child cellular health as indicated by shorter TL at 4 and 5 years of age.Similarly, children with oppositional defiant behavior also had shorter TL, possibly related to early exposures to maternal clinical depression.Our study is the first to link maternal clinical depression and oppositional defiant behavior with shorter TL in the preschool years in a relatively homogenous population of low-income Latino children.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.

ABSTRACT
Exposure to psychological stress and depression are associated with shorter white blood cell telomere length (TL) in adults, possibly via associated lifelong oxidative stressors. Exposure to maternal depression increases risk for future depression and behavior problems in children, and Latino youth are at high risk. Few studies have evaluated the role of exposure to maternal depression or child behavior in relation to TL in children. We assessed early-childhood exposures to maternal depression from birth to the age of 5 years and child behavior from ages 3-5 years in a cohort of Latino children in relation to child leukocyte TL at ages 4 and 5 years. Children who had oppositional defiant behavior at 3, 4 or 5 years had shorter TL than those without by ~450 base pairs (P < 0.01). In multivariate analyses, independent predictors for shorter TL at 4 and 5 years of age included oppositional defiant disorder at 3, 4 or 5 years (β = -359.25, 95% CI -633.84 to 84.66; P = 0.01), exposure to maternal clinical depression at 3 years of age (β = -363.99, 95% CI -651.24 to 764.74; P = 0.01), shorter maternal TL (β = 502.92, 95% CI 189.21-816.63) and younger paternal age at the child's birth (β = 24.63, 95% CI 1.14-48.12). Thus, exposure to maternal clinical depression (versus depressive symptoms) in early childhood was associated with deleterious consequences on child cellular health as indicated by shorter TL at 4 and 5 years of age. Similarly, children with oppositional defiant behavior also had shorter TL, possibly related to early exposures to maternal clinical depression. Our study is the first to link maternal clinical depression and oppositional defiant behavior with shorter TL in the preschool years in a relatively homogenous population of low-income Latino children.

No MeSH data available.


Related in: MedlinePlus

The frequency of telomere length for those with any oppositional defiant behavior versus none. The x axis is telomere length in base pairs and y axis is probability with the area under the curve representing 1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4490282&req=5

fig1: The frequency of telomere length for those with any oppositional defiant behavior versus none. The x axis is telomere length in base pairs and y axis is probability with the area under the curve representing 1.

Mentions: We found statistically significant associations between child behavior at 3, 4 and 5 years of age and TL. Child anxiety at 5 years of age was associated with reduced TL by ~350 base pairs (7479.73±97.07 versus 7818.05±69.32; P<0.01). At 4 years of age, TL was also slightly but not statistically significantly lower in those children with anxiety (7552.01±164.40 versus 7823.48±69.62; P=0.13). Children with oppositional defiant behavior at 3 and 4 years had shorter TL compared with those without oppositional defiant behavior (6981.04±336.02 versus 7816.29±66.83; P=0.02 for 3 years and 7401.84±155.20 versus 7822.30±68.69; P=0.01 for 4 years; Table 2). Children who had oppositional defiant behavior at 3, 4 or 5 years (11/117 or 9.4%) also had shorter TL than those without (7366.03±176.64 versus 7847.69±71.27, or approximately a 500-base-pair difference (P=0.01) (Figure 1). We were unable to examine the relationship between chronic child behavior issues and TL because of the small sample size in the groups with chronic behavior issues beyond one time point.


Telomere length is associated with oppositional defiant behavior and maternal clinical depression in Latino preschool children.

Wojcicki JM, Heyman MB, Elwan D, Shiboski S, Lin J, Blackburn E, Epel E - Transl Psychiatry (2015)

The frequency of telomere length for those with any oppositional defiant behavior versus none. The x axis is telomere length in base pairs and y axis is probability with the area under the curve representing 1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4490282&req=5

fig1: The frequency of telomere length for those with any oppositional defiant behavior versus none. The x axis is telomere length in base pairs and y axis is probability with the area under the curve representing 1.
Mentions: We found statistically significant associations between child behavior at 3, 4 and 5 years of age and TL. Child anxiety at 5 years of age was associated with reduced TL by ~350 base pairs (7479.73±97.07 versus 7818.05±69.32; P<0.01). At 4 years of age, TL was also slightly but not statistically significantly lower in those children with anxiety (7552.01±164.40 versus 7823.48±69.62; P=0.13). Children with oppositional defiant behavior at 3 and 4 years had shorter TL compared with those without oppositional defiant behavior (6981.04±336.02 versus 7816.29±66.83; P=0.02 for 3 years and 7401.84±155.20 versus 7822.30±68.69; P=0.01 for 4 years; Table 2). Children who had oppositional defiant behavior at 3, 4 or 5 years (11/117 or 9.4%) also had shorter TL than those without (7366.03±176.64 versus 7847.69±71.27, or approximately a 500-base-pair difference (P=0.01) (Figure 1). We were unable to examine the relationship between chronic child behavior issues and TL because of the small sample size in the groups with chronic behavior issues beyond one time point.

Bottom Line: Thus, exposure to maternal clinical depression (versus depressive symptoms) in early childhood was associated with deleterious consequences on child cellular health as indicated by shorter TL at 4 and 5 years of age.Similarly, children with oppositional defiant behavior also had shorter TL, possibly related to early exposures to maternal clinical depression.Our study is the first to link maternal clinical depression and oppositional defiant behavior with shorter TL in the preschool years in a relatively homogenous population of low-income Latino children.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.

ABSTRACT
Exposure to psychological stress and depression are associated with shorter white blood cell telomere length (TL) in adults, possibly via associated lifelong oxidative stressors. Exposure to maternal depression increases risk for future depression and behavior problems in children, and Latino youth are at high risk. Few studies have evaluated the role of exposure to maternal depression or child behavior in relation to TL in children. We assessed early-childhood exposures to maternal depression from birth to the age of 5 years and child behavior from ages 3-5 years in a cohort of Latino children in relation to child leukocyte TL at ages 4 and 5 years. Children who had oppositional defiant behavior at 3, 4 or 5 years had shorter TL than those without by ~450 base pairs (P < 0.01). In multivariate analyses, independent predictors for shorter TL at 4 and 5 years of age included oppositional defiant disorder at 3, 4 or 5 years (β = -359.25, 95% CI -633.84 to 84.66; P = 0.01), exposure to maternal clinical depression at 3 years of age (β = -363.99, 95% CI -651.24 to 764.74; P = 0.01), shorter maternal TL (β = 502.92, 95% CI 189.21-816.63) and younger paternal age at the child's birth (β = 24.63, 95% CI 1.14-48.12). Thus, exposure to maternal clinical depression (versus depressive symptoms) in early childhood was associated with deleterious consequences on child cellular health as indicated by shorter TL at 4 and 5 years of age. Similarly, children with oppositional defiant behavior also had shorter TL, possibly related to early exposures to maternal clinical depression. Our study is the first to link maternal clinical depression and oppositional defiant behavior with shorter TL in the preschool years in a relatively homogenous population of low-income Latino children.

No MeSH data available.


Related in: MedlinePlus