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Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps.

Park M, Mendes PV, Hirota AS, dos Santos EV, Costa EL, Azevedo LC - Rev Bras Ter Intensiva (2015 Apr-Jun)

Bottom Line: Blood flow/pump rotation ratio variations are negatively associated with transmembrane pressure (R2 = 0.5 for blood flow = 1500mL/minute and R2 = 0.4 for blood flow = 3500mL/minute, both with p < 0.001) and positively associated with CO2 transfer variations (R2 = 0.2 for sweep gas flow ≤ 6L/minute, p < 0.001, and R2 = 0.1 for sweep gas flow > 6L/minute, p = 0.006), and the blood flow/pump rotation ratio is not associated with O2 transfer variations (R2 = 0.01 for blood flow = 1500mL/minute, p = 0.19, and R2 = - 0.01 for blood flow = 3500 mL/minute, p = 0.46).Blood flow/pump rotation ratio variation is negatively associated with transmembrane pressure and positively associated with CO2 transfer in this animal model.According to the clinical situation, a decrease in the blood flow/pump rotation ratio can indicate artificial lung dysfunction without the occurrence of hypoxemia.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Emergências Clínicas, Unidade de Terapia Intensiva, Hospital das Clínicas de São Paulo, São Paulo, SP, Brasil.

ABSTRACT

Objective: To analyze the correlations of the blood flow/pump rotation ratio and the transmembrane pressure, CO2 and O2 transfer during the extracorporeal respiratory support.

Methods: Five animals were instrumented and submitted to extracorporeal membrane oxygenation in a five-step protocol, including abdominal sepsis and lung injury.

Results: This study showed that blood flow/pump rotations ratio variations are dependent on extracorporeal membrane oxygenation blood flow in a positive logarithmic fashion. Blood flow/pump rotation ratio variations are negatively associated with transmembrane pressure (R2 = 0.5 for blood flow = 1500mL/minute and R2 = 0.4 for blood flow = 3500mL/minute, both with p < 0.001) and positively associated with CO2 transfer variations (R2 = 0.2 for sweep gas flow ≤ 6L/minute, p < 0.001, and R2 = 0.1 for sweep gas flow > 6L/minute, p = 0.006), and the blood flow/pump rotation ratio is not associated with O2 transfer variations (R2 = 0.01 for blood flow = 1500mL/minute, p = 0.19, and R2 = - 0.01 for blood flow = 3500 mL/minute, p = 0.46).

Conclusion: Blood flow/pump rotation ratio variation is negatively associated with transmembrane pressure and positively associated with CO2 transfer in this animal model. According to the clinical situation, a decrease in the blood flow/pump rotation ratio can indicate artificial lung dysfunction without the occurrence of hypoxemia.

No MeSH data available.


Related in: MedlinePlus

Correlation between the blood flow/rotations ratio and CO2 transfer.Panel A) correlation of 98 pairs of data with a sweep gas flow ≤6L/minute, and Panel B) correlation of 94 pairs of data with a sweep gas flow> 6L/minute.BFRR - blood flow/rotations ratio.
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f05: Correlation between the blood flow/rotations ratio and CO2 transfer.Panel A) correlation of 98 pairs of data with a sweep gas flow ≤6L/minute, and Panel B) correlation of 94 pairs of data with a sweep gas flow> 6L/minute.BFRR - blood flow/rotations ratio.

Mentions: The correlations between CO2 transfer and BFRR are presented in figure 5 (Panels A and B), stratified according tothe sweep gas flow ≤ 6L/minute or > 6L/minute, respectively.


Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps.

Park M, Mendes PV, Hirota AS, dos Santos EV, Costa EL, Azevedo LC - Rev Bras Ter Intensiva (2015 Apr-Jun)

Correlation between the blood flow/rotations ratio and CO2 transfer.Panel A) correlation of 98 pairs of data with a sweep gas flow ≤6L/minute, and Panel B) correlation of 94 pairs of data with a sweep gas flow> 6L/minute.BFRR - blood flow/rotations ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4489787&req=5

f05: Correlation between the blood flow/rotations ratio and CO2 transfer.Panel A) correlation of 98 pairs of data with a sweep gas flow ≤6L/minute, and Panel B) correlation of 94 pairs of data with a sweep gas flow> 6L/minute.BFRR - blood flow/rotations ratio.
Mentions: The correlations between CO2 transfer and BFRR are presented in figure 5 (Panels A and B), stratified according tothe sweep gas flow ≤ 6L/minute or > 6L/minute, respectively.

Bottom Line: Blood flow/pump rotation ratio variations are negatively associated with transmembrane pressure (R2 = 0.5 for blood flow = 1500mL/minute and R2 = 0.4 for blood flow = 3500mL/minute, both with p < 0.001) and positively associated with CO2 transfer variations (R2 = 0.2 for sweep gas flow ≤ 6L/minute, p < 0.001, and R2 = 0.1 for sweep gas flow > 6L/minute, p = 0.006), and the blood flow/pump rotation ratio is not associated with O2 transfer variations (R2 = 0.01 for blood flow = 1500mL/minute, p = 0.19, and R2 = - 0.01 for blood flow = 3500 mL/minute, p = 0.46).Blood flow/pump rotation ratio variation is negatively associated with transmembrane pressure and positively associated with CO2 transfer in this animal model.According to the clinical situation, a decrease in the blood flow/pump rotation ratio can indicate artificial lung dysfunction without the occurrence of hypoxemia.

View Article: PubMed Central - PubMed

Affiliation: Departamento de Emergências Clínicas, Unidade de Terapia Intensiva, Hospital das Clínicas de São Paulo, São Paulo, SP, Brasil.

ABSTRACT

Objective: To analyze the correlations of the blood flow/pump rotation ratio and the transmembrane pressure, CO2 and O2 transfer during the extracorporeal respiratory support.

Methods: Five animals were instrumented and submitted to extracorporeal membrane oxygenation in a five-step protocol, including abdominal sepsis and lung injury.

Results: This study showed that blood flow/pump rotations ratio variations are dependent on extracorporeal membrane oxygenation blood flow in a positive logarithmic fashion. Blood flow/pump rotation ratio variations are negatively associated with transmembrane pressure (R2 = 0.5 for blood flow = 1500mL/minute and R2 = 0.4 for blood flow = 3500mL/minute, both with p < 0.001) and positively associated with CO2 transfer variations (R2 = 0.2 for sweep gas flow ≤ 6L/minute, p < 0.001, and R2 = 0.1 for sweep gas flow > 6L/minute, p = 0.006), and the blood flow/pump rotation ratio is not associated with O2 transfer variations (R2 = 0.01 for blood flow = 1500mL/minute, p = 0.19, and R2 = - 0.01 for blood flow = 3500 mL/minute, p = 0.46).

Conclusion: Blood flow/pump rotation ratio variation is negatively associated with transmembrane pressure and positively associated with CO2 transfer in this animal model. According to the clinical situation, a decrease in the blood flow/pump rotation ratio can indicate artificial lung dysfunction without the occurrence of hypoxemia.

No MeSH data available.


Related in: MedlinePlus