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Have You Ever Seen the Impact of Crossing Fiber in DTI?: Demonstration of the Corticospinal Tract Pathway.

Lee DH, Park JW, Park SH, Hong C - PLoS ONE (2015)

Bottom Line: The identification of the corticospinal tract (CST) pathway with a deterministic fiber tracking approach is limited because of crossing fibers, especially for the hand fibers of the CST due to the crossing superior longitudinal fasciculus (SLF).The apparent diffusion coefficient (ADC), fractional anisotropy (FA), relative anisotropy (RA), and volume ratio (VR) were measured based on the extracted fiber tracts.Our results clearly show the impact of the crossing fiber for the hand motor fibers of the CST pathway with deterministic tracking algorithms in diffusion tensor tractography.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

ABSTRACT

Objective: The identification of the corticospinal tract (CST) pathway with a deterministic fiber tracking approach is limited because of crossing fibers, especially for the hand fibers of the CST due to the crossing superior longitudinal fasciculus (SLF). We examined a patient with congenital bilateral perisylvian syndrome (CBPS) who did not have the SLF, in order to visualize CST hand fibers that were not affected by crossing fibers.

Methods: A 10-year-old girl without the SLF due to CBPS and three normal healthy subjects participated in this study. We used a deterministic fiber tracking algorithm, and the regions of interest (ROIs) were drawn in the posterior limb of internal capsule (PLIC) and the primary motor cortex. The apparent diffusion coefficient (ADC), fractional anisotropy (FA), relative anisotropy (RA), and volume ratio (VR) were measured based on the extracted fiber tracts.

Results: The ADC values were not different between the normal subjects and the patient with CBPS. The FA, RA, and VR values of the normal subjects were similar, but were relatively higher than those of the patient with CBPS.

Conclusion: Our results clearly show the impact of the crossing fiber for the hand motor fibers of the CST pathway with deterministic tracking algorithms in diffusion tensor tractography.

No MeSH data available.


Related in: MedlinePlus

The measured quantitative values of the apparent diffusion coefficient (ADC), FA, relative anisotropy (RA), and the volume ratio (VR) for one patient with CBPS and three normal subjects.The values represent the mean (± standard deviation).
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pone.0112045.g002: The measured quantitative values of the apparent diffusion coefficient (ADC), FA, relative anisotropy (RA), and the volume ratio (VR) for one patient with CBPS and three normal subjects.The values represent the mean (± standard deviation).

Mentions: Fig 2 shows the means and standard deviations of the ADC, FA, RA, and VR values. The ADC values between the normal subjects and the patient with CBPS were not significantly different. The FA, RA, and VR values in the normal subjects were similar to each other and relatively higher compared to the patient with CBPS. The percentage differences in the FA, RA, and VR values among the subjects were about 20%, 30%, and 40%, respectively.


Have You Ever Seen the Impact of Crossing Fiber in DTI?: Demonstration of the Corticospinal Tract Pathway.

Lee DH, Park JW, Park SH, Hong C - PLoS ONE (2015)

The measured quantitative values of the apparent diffusion coefficient (ADC), FA, relative anisotropy (RA), and the volume ratio (VR) for one patient with CBPS and three normal subjects.The values represent the mean (± standard deviation).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4489772&req=5

pone.0112045.g002: The measured quantitative values of the apparent diffusion coefficient (ADC), FA, relative anisotropy (RA), and the volume ratio (VR) for one patient with CBPS and three normal subjects.The values represent the mean (± standard deviation).
Mentions: Fig 2 shows the means and standard deviations of the ADC, FA, RA, and VR values. The ADC values between the normal subjects and the patient with CBPS were not significantly different. The FA, RA, and VR values in the normal subjects were similar to each other and relatively higher compared to the patient with CBPS. The percentage differences in the FA, RA, and VR values among the subjects were about 20%, 30%, and 40%, respectively.

Bottom Line: The identification of the corticospinal tract (CST) pathway with a deterministic fiber tracking approach is limited because of crossing fibers, especially for the hand fibers of the CST due to the crossing superior longitudinal fasciculus (SLF).The apparent diffusion coefficient (ADC), fractional anisotropy (FA), relative anisotropy (RA), and volume ratio (VR) were measured based on the extracted fiber tracts.Our results clearly show the impact of the crossing fiber for the hand motor fibers of the CST pathway with deterministic tracking algorithms in diffusion tensor tractography.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

ABSTRACT

Objective: The identification of the corticospinal tract (CST) pathway with a deterministic fiber tracking approach is limited because of crossing fibers, especially for the hand fibers of the CST due to the crossing superior longitudinal fasciculus (SLF). We examined a patient with congenital bilateral perisylvian syndrome (CBPS) who did not have the SLF, in order to visualize CST hand fibers that were not affected by crossing fibers.

Methods: A 10-year-old girl without the SLF due to CBPS and three normal healthy subjects participated in this study. We used a deterministic fiber tracking algorithm, and the regions of interest (ROIs) were drawn in the posterior limb of internal capsule (PLIC) and the primary motor cortex. The apparent diffusion coefficient (ADC), fractional anisotropy (FA), relative anisotropy (RA), and volume ratio (VR) were measured based on the extracted fiber tracts.

Results: The ADC values were not different between the normal subjects and the patient with CBPS. The FA, RA, and VR values of the normal subjects were similar, but were relatively higher than those of the patient with CBPS.

Conclusion: Our results clearly show the impact of the crossing fiber for the hand motor fibers of the CST pathway with deterministic tracking algorithms in diffusion tensor tractography.

No MeSH data available.


Related in: MedlinePlus