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High Mannose-Binding Lectin Serum Levels Are Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes.

Huang Q, Shang G, Deng H, Liu J, Mei Y, Xu Y - PLoS ONE (2015)

Bottom Line: MBL improved the area under the receiver operating characteristic curve of the diabetes duration for DRfrom 0.82(95% confidence interval [CI], 0.77-0.86) to 0.88(95% CI, 0.82-0.96; P<0.01) and for VDTR from 0.85(95% CI, 0.77-0.92) to 0.90(95% CI, 0.83-0.96; P<0.01).Multivariate logistic regression analysis adjusted for common risk factors showed that serum MBL levels(per log-unit increase) was an independent predictor of DR (OR=3.45; 95%CI: 1.42-7.05) and VTDR (OR=4.42; 95%CI: 1.51-8.18).MBL is a novel, independent diagnostic marker of DR in type 2 diabetic patients, suggesting that MBL may be involved in the pathogenesis of DR in diabetic patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei province, P. R. China.

ABSTRACT

Objective: To investigate mannose-binding lectin (MBL) serum levels in type 2 diabetic patients with and without diabetic retinopathy (DR).

Methods: Serum MBL levels were determined in type 2 diabetic patients (N=324) as well as in 300 healthy control Subjects. Multivariate analyses were performed using logistic regression models. Receiver operating characteristic curves (ROC) was used to test the overall predict accuracy of MBL and other markers.

Results: Diabetic patients with DR and vision-threatening diabetic retinopathy (VTDR) had significantly higher MBL levels on admission (P<0.0001 and P<0.0001). MBL improved the area under the receiver operating characteristic curve of the diabetes duration for DRfrom 0.82(95% confidence interval [CI], 0.77-0.86) to 0.88(95% CI, 0.82-0.96; P<0.01) and for VDTR from 0.85(95% CI, 0.77-0.92) to 0.90(95% CI, 0.83-0.96; P<0.01). Multivariate logistic regression analysis adjusted for common risk factors showed that serum MBL levels(per log-unit increase) was an independent predictor of DR (OR=3.45; 95%CI: 1.42-7.05) and VTDR (OR=4.42; 95%CI: 1.51-8.18).

Conclusion: MBL is a novel, independent diagnostic marker of DR in type 2 diabetic patients, suggesting that MBL may be involved in the pathogenesis of DR in diabetic patients.

No MeSH data available.


Related in: MedlinePlus

A separate histogram of serum MBL levels in diabetic patientsand normal controls.The horizontal lines in the top indicate mean levels.Pvalues refer to Mann-Whitney U tests for differencesbetween groups.
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pone.0130665.g001: A separate histogram of serum MBL levels in diabetic patientsand normal controls.The horizontal lines in the top indicate mean levels.Pvalues refer to Mann-Whitney U tests for differencesbetween groups.

Mentions: The results indicated that the serum MBL levels were significantly (P<0.0001) higher in diabetes patients as compared to normal cases [2976(IQR, 2421–3521μg/L); 732(IQR, 576–894μg/L), respectively; Fig 1]. There was a modest positive correlation between levels of MBL and HbA1c (r = 0.385, P<0.0001; Fig 2A). In addition, there was a significant, albeit weak, positive correlation between MBL levels and Hs-CRP (r = 0.159, P = 0.004; Fig 2B). Furthermore, there was no correlation between serumlevels of MBL and others factors, such as, sex, age, creatinine, triglyceride, cholesterol, LDL and HDL, duration of diabetes, or daily insulin dose(P>0.05).


High Mannose-Binding Lectin Serum Levels Are Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes.

Huang Q, Shang G, Deng H, Liu J, Mei Y, Xu Y - PLoS ONE (2015)

A separate histogram of serum MBL levels in diabetic patientsand normal controls.The horizontal lines in the top indicate mean levels.Pvalues refer to Mann-Whitney U tests for differencesbetween groups.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4489651&req=5

pone.0130665.g001: A separate histogram of serum MBL levels in diabetic patientsand normal controls.The horizontal lines in the top indicate mean levels.Pvalues refer to Mann-Whitney U tests for differencesbetween groups.
Mentions: The results indicated that the serum MBL levels were significantly (P<0.0001) higher in diabetes patients as compared to normal cases [2976(IQR, 2421–3521μg/L); 732(IQR, 576–894μg/L), respectively; Fig 1]. There was a modest positive correlation between levels of MBL and HbA1c (r = 0.385, P<0.0001; Fig 2A). In addition, there was a significant, albeit weak, positive correlation between MBL levels and Hs-CRP (r = 0.159, P = 0.004; Fig 2B). Furthermore, there was no correlation between serumlevels of MBL and others factors, such as, sex, age, creatinine, triglyceride, cholesterol, LDL and HDL, duration of diabetes, or daily insulin dose(P>0.05).

Bottom Line: MBL improved the area under the receiver operating characteristic curve of the diabetes duration for DRfrom 0.82(95% confidence interval [CI], 0.77-0.86) to 0.88(95% CI, 0.82-0.96; P<0.01) and for VDTR from 0.85(95% CI, 0.77-0.92) to 0.90(95% CI, 0.83-0.96; P<0.01).Multivariate logistic regression analysis adjusted for common risk factors showed that serum MBL levels(per log-unit increase) was an independent predictor of DR (OR=3.45; 95%CI: 1.42-7.05) and VTDR (OR=4.42; 95%CI: 1.51-8.18).MBL is a novel, independent diagnostic marker of DR in type 2 diabetic patients, suggesting that MBL may be involved in the pathogenesis of DR in diabetic patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei province, P. R. China.

ABSTRACT

Objective: To investigate mannose-binding lectin (MBL) serum levels in type 2 diabetic patients with and without diabetic retinopathy (DR).

Methods: Serum MBL levels were determined in type 2 diabetic patients (N=324) as well as in 300 healthy control Subjects. Multivariate analyses were performed using logistic regression models. Receiver operating characteristic curves (ROC) was used to test the overall predict accuracy of MBL and other markers.

Results: Diabetic patients with DR and vision-threatening diabetic retinopathy (VTDR) had significantly higher MBL levels on admission (P<0.0001 and P<0.0001). MBL improved the area under the receiver operating characteristic curve of the diabetes duration for DRfrom 0.82(95% confidence interval [CI], 0.77-0.86) to 0.88(95% CI, 0.82-0.96; P<0.01) and for VDTR from 0.85(95% CI, 0.77-0.92) to 0.90(95% CI, 0.83-0.96; P<0.01). Multivariate logistic regression analysis adjusted for common risk factors showed that serum MBL levels(per log-unit increase) was an independent predictor of DR (OR=3.45; 95%CI: 1.42-7.05) and VTDR (OR=4.42; 95%CI: 1.51-8.18).

Conclusion: MBL is a novel, independent diagnostic marker of DR in type 2 diabetic patients, suggesting that MBL may be involved in the pathogenesis of DR in diabetic patients.

No MeSH data available.


Related in: MedlinePlus