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The relationship of area under temperature curve during MR guided HIFU and diffusion coefficient in patient screening

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Different type of fibroid shows different response to MR guided HIFU, which is believed to reflect different blood suplly... Our study is to assess the relationship of AUC (area under curve) calculated from the temperature curve during sonication in MR guided HIFU therapy for fibroid and the diffusion coefficient derived from multiple b-values DW-MRI in patient screening... In the screening, subjects were positioned prone, feet first, on the 3T MRI scanner (Achieva TX, Philips Medical Systems, Best, the Netherlands) using a 32-channel phased array coil... IVIM MR images were acquired on the axial plan across the uterus... For low b-value (<100 s/mm2), monoexp model was used to calculate diffusion coefficient which mainly represented blood perfusion... Thermometry got during the treatments was used to create temperature curves... For better interpretation, two points were chosen on the temperature curve: The first point was the time point at the end of the ascending segment before the temperature got stable... The second point was the time point at the beginning of the descending segment before the temperature began to decay... Fibroids with relatively high AUC which represented more energy during sonication had large diffusion coefficient representative of hyper blood perfusion... However, there was no statistically significant difference of diffusion coefficient among the 3 group (p=0.121)... Conclusion: AUC of the temperature curve was related with diffusion coefficient derived from multiple b-values combined with DW-MRI which correlated very well with the biological features of fibroids such as vascularity... Fibroids with high diffusion coefficient representative of hyper blood perfusion need more sonication energy during MR guided HIFU which ensures good therapeutic effects.

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The relationship of area under temperature curve during MR guided HIFU and diffusion coefficient in patient screening
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4489503&req=5

View Article: PubMed Central - HTML

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Different type of fibroid shows different response to MR guided HIFU, which is believed to reflect different blood suplly... Our study is to assess the relationship of AUC (area under curve) calculated from the temperature curve during sonication in MR guided HIFU therapy for fibroid and the diffusion coefficient derived from multiple b-values DW-MRI in patient screening... In the screening, subjects were positioned prone, feet first, on the 3T MRI scanner (Achieva TX, Philips Medical Systems, Best, the Netherlands) using a 32-channel phased array coil... IVIM MR images were acquired on the axial plan across the uterus... For low b-value (<100 s/mm2), monoexp model was used to calculate diffusion coefficient which mainly represented blood perfusion... Thermometry got during the treatments was used to create temperature curves... For better interpretation, two points were chosen on the temperature curve: The first point was the time point at the end of the ascending segment before the temperature got stable... The second point was the time point at the beginning of the descending segment before the temperature began to decay... Fibroids with relatively high AUC which represented more energy during sonication had large diffusion coefficient representative of hyper blood perfusion... However, there was no statistically significant difference of diffusion coefficient among the 3 group (p=0.121)... Conclusion: AUC of the temperature curve was related with diffusion coefficient derived from multiple b-values combined with DW-MRI which correlated very well with the biological features of fibroids such as vascularity... Fibroids with high diffusion coefficient representative of hyper blood perfusion need more sonication energy during MR guided HIFU which ensures good therapeutic effects.

No MeSH data available.