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Attenuated cerebral vasodilatory capacity in response to hypercapnia in college-aged African Americans.

Hurr C, Kim K, Harrison ML, Brothers RM - Exp. Physiol. (2014)

Bottom Line: What is the central question of this study?Twenty-one healthy, college-aged AA (10 male) and 21 age- and sex-matched CA (10 male) subjects participated in this study.A four-parameter logistic regression was used for curve fitting the responses of CBFV and CVCI relative to changes in P(ET,CO2).

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Affiliation: Environmental and Autonomic Physiology Laboratory, Department of Kinesiology and Health Education, The University of Texas at Austin, TX, USA.

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Group differences for a and y0Total range of change in CVCI and CBFV (parameter a; A) as well as the maximal increase in CVCI and CBFV (parameter y0; B) during hypercapnic period were attenuated in AA relative to CA. The left Y axis in each figure represents the CVCI values while the right Y axis in each figure represents the CBFV values. Values are shown as means + SD. *P < 0.001.
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fig03: Group differences for a and y0Total range of change in CVCI and CBFV (parameter a; A) as well as the maximal increase in CVCI and CBFV (parameter y0; B) during hypercapnic period were attenuated in AA relative to CA. The left Y axis in each figure represents the CVCI values while the right Y axis in each figure represents the CBFV values. Values are shown as means + SD. *P < 0.001.

Mentions: The correlation coefficients (r2) for logistic regression were 0.95 and 0.94 for CBFV versus and CVCI versus, respectively. From Table 3, the total range of changes in CBFV (a; as a percentage) was attenuated in AAs (CA, 101 ± 18% versus AA, 69 ± 23%; P < 0.001). Likewise, the total range of changes in CVCI (a; as a percentage) was reduced in AAs (CA, 83 ± 21% versus AA, 58 ± 21%; P < 0.001). The maximal increase in CBFV (y0; as a percentage) was lower in AAs (CA, 205 ± 24% versus AA, 169 ± 24%; P < 0.001). Likewise, the maximal increase in CVCI (y0; as a percentage) was lower in AAs (CA, 188 ± 28% versus AA, 154 ± 19%; P < 0.001). The levels of that exhibited the highest CO2 sensitivity (x0; in millimetres of mercury) were not different between the two groups. Group differences for a and y0 are shown graphically in Fig.3A and B, respectively.


Attenuated cerebral vasodilatory capacity in response to hypercapnia in college-aged African Americans.

Hurr C, Kim K, Harrison ML, Brothers RM - Exp. Physiol. (2014)

Group differences for a and y0Total range of change in CVCI and CBFV (parameter a; A) as well as the maximal increase in CVCI and CBFV (parameter y0; B) during hypercapnic period were attenuated in AA relative to CA. The left Y axis in each figure represents the CVCI values while the right Y axis in each figure represents the CBFV values. Values are shown as means + SD. *P < 0.001.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4489322&req=5

fig03: Group differences for a and y0Total range of change in CVCI and CBFV (parameter a; A) as well as the maximal increase in CVCI and CBFV (parameter y0; B) during hypercapnic period were attenuated in AA relative to CA. The left Y axis in each figure represents the CVCI values while the right Y axis in each figure represents the CBFV values. Values are shown as means + SD. *P < 0.001.
Mentions: The correlation coefficients (r2) for logistic regression were 0.95 and 0.94 for CBFV versus and CVCI versus, respectively. From Table 3, the total range of changes in CBFV (a; as a percentage) was attenuated in AAs (CA, 101 ± 18% versus AA, 69 ± 23%; P < 0.001). Likewise, the total range of changes in CVCI (a; as a percentage) was reduced in AAs (CA, 83 ± 21% versus AA, 58 ± 21%; P < 0.001). The maximal increase in CBFV (y0; as a percentage) was lower in AAs (CA, 205 ± 24% versus AA, 169 ± 24%; P < 0.001). Likewise, the maximal increase in CVCI (y0; as a percentage) was lower in AAs (CA, 188 ± 28% versus AA, 154 ± 19%; P < 0.001). The levels of that exhibited the highest CO2 sensitivity (x0; in millimetres of mercury) were not different between the two groups. Group differences for a and y0 are shown graphically in Fig.3A and B, respectively.

Bottom Line: What is the central question of this study?Twenty-one healthy, college-aged AA (10 male) and 21 age- and sex-matched CA (10 male) subjects participated in this study.A four-parameter logistic regression was used for curve fitting the responses of CBFV and CVCI relative to changes in P(ET,CO2).

View Article: PubMed Central - PubMed

Affiliation: Environmental and Autonomic Physiology Laboratory, Department of Kinesiology and Health Education, The University of Texas at Austin, TX, USA.

Show MeSH
Related in: MedlinePlus