Limits...
Giant parietal lobe infantile gliosarcoma in a 5-year-old child.

Savant HV, Balasubramaniam S, Mahajan V - J Pediatr Neurosci (2015 Apr-Jun)

Bottom Line: A 5-year-old female child came to us with history of fever and loss of appetite since 2 weeks and right sided weakness since 4 days.The patient was given adjuvant therapy following surgery and survived until 9 months following surgery.The etiopathogenesis, treatment modalities and prognosis of GSM is discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, BYL Nair Hospital and T.N. Medical College, Mumbai, Maharashtra, India.

ABSTRACT
The relative frequency of pediatric gliosarcoma (GSM) is 1.9% among glioblastomas and 0.5% among pediatric central nervous system tumors. A 5-year-old female child came to us with history of fever and loss of appetite since 2 weeks and right sided weakness since 4 days. Magnetic resonance imaging showed a large heterogeneously enhancing space occupying lesion in the left parieto-occipital region. A parieto-occipital craniotomy with radical excision of tumor was performed. The patient was given adjuvant therapy following surgery and survived until 9 months following surgery. The etiopathogenesis, treatment modalities and prognosis of GSM is discussed.

No MeSH data available.


Related in: MedlinePlus

The small cortisectomy through which piecemeal excision of the tumor was performed
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4489064&req=5

Figure 3: The small cortisectomy through which piecemeal excision of the tumor was performed

Mentions: The patient was operated in right lateral position. A parieto-occipital craniotomy was performed, and the brain was found to be extremely tense. A small cortisectomy was done in the posterior parietal region and tumor identified [Figure 3]. The tumor was grayish in color, firm in consistency and had a good plane of cleavage from surrounding brain parenchyma. The lesion was excised completely in piecemeal fashion. The choroid plexus with ependyma was found adherent to the capsule that was preserved. Histopathology was suggestive of the malignant spindle cell tumor with densely packed tumor cells. Immunohistochemistry (IHC) was performed which was IHC-negative for glial fibrillary acidic protein and S-100. MIB-1 labeling index at some areas was up to 40%.


Giant parietal lobe infantile gliosarcoma in a 5-year-old child.

Savant HV, Balasubramaniam S, Mahajan V - J Pediatr Neurosci (2015 Apr-Jun)

The small cortisectomy through which piecemeal excision of the tumor was performed
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4489064&req=5

Figure 3: The small cortisectomy through which piecemeal excision of the tumor was performed
Mentions: The patient was operated in right lateral position. A parieto-occipital craniotomy was performed, and the brain was found to be extremely tense. A small cortisectomy was done in the posterior parietal region and tumor identified [Figure 3]. The tumor was grayish in color, firm in consistency and had a good plane of cleavage from surrounding brain parenchyma. The lesion was excised completely in piecemeal fashion. The choroid plexus with ependyma was found adherent to the capsule that was preserved. Histopathology was suggestive of the malignant spindle cell tumor with densely packed tumor cells. Immunohistochemistry (IHC) was performed which was IHC-negative for glial fibrillary acidic protein and S-100. MIB-1 labeling index at some areas was up to 40%.

Bottom Line: A 5-year-old female child came to us with history of fever and loss of appetite since 2 weeks and right sided weakness since 4 days.The patient was given adjuvant therapy following surgery and survived until 9 months following surgery.The etiopathogenesis, treatment modalities and prognosis of GSM is discussed.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, BYL Nair Hospital and T.N. Medical College, Mumbai, Maharashtra, India.

ABSTRACT
The relative frequency of pediatric gliosarcoma (GSM) is 1.9% among glioblastomas and 0.5% among pediatric central nervous system tumors. A 5-year-old female child came to us with history of fever and loss of appetite since 2 weeks and right sided weakness since 4 days. Magnetic resonance imaging showed a large heterogeneously enhancing space occupying lesion in the left parieto-occipital region. A parieto-occipital craniotomy with radical excision of tumor was performed. The patient was given adjuvant therapy following surgery and survived until 9 months following surgery. The etiopathogenesis, treatment modalities and prognosis of GSM is discussed.

No MeSH data available.


Related in: MedlinePlus