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Association between Periodontitis and Alzheimer's Disease.

Abbayya K, Puthanakar NY, Naduwinmani S, Chidambar YS - N Am J Med Sci (2015)

Bottom Line: Alzheimer's disease (AD) is a neurodegenerative disease which significantly increases with age.Its onset can be either early or late.AD is characterized by the salient inflammatory features, microglial activation, and increased levels of proinflammatory cytokines which contribute to the inflammatory status of the central nervous system (CNS).

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, Satara, India.

ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease which significantly increases with age. Its onset can be either early or late. AD is characterized by the salient inflammatory features, microglial activation, and increased levels of proinflammatory cytokines which contribute to the inflammatory status of the central nervous system (CNS). Whereas, periodontitis is a common oral infection associated with the gram negative anaerobic bacteria. Periodontitis can be marked as a "low-grade systemic disease" by release of proinflammatory cytokines into systemic circulation and elevation of C-reactive protein (CRP). Inflammation is known to play a pivotal role in both the disease process serving as a connecting link between periodontitis and AD. The present review throws a light on possible enigmatic link between AD and periodontitis. This review is designed by collecting data from PubMed database using key words like "Alzheimer's disease", "inflammation", "periodontitis", and "proinflammatory cytokines".

No MeSH data available.


Related in: MedlinePlus

Possible pathway between periodontal infection and AD
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Figure 3: Possible pathway between periodontal infection and AD

Mentions: Periodontal pathogens have the capability to gain access to systemic circulation and subsequently colonize different distant anatomic sites in the body. For example, periodontal bacteria have been implicated in several systemic diseases including endocarditis and brain abscesses [Figure 3].Figure 3


Association between Periodontitis and Alzheimer's Disease.

Abbayya K, Puthanakar NY, Naduwinmani S, Chidambar YS - N Am J Med Sci (2015)

Possible pathway between periodontal infection and AD
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488989&req=5

Figure 3: Possible pathway between periodontal infection and AD
Mentions: Periodontal pathogens have the capability to gain access to systemic circulation and subsequently colonize different distant anatomic sites in the body. For example, periodontal bacteria have been implicated in several systemic diseases including endocarditis and brain abscesses [Figure 3].Figure 3

Bottom Line: Alzheimer's disease (AD) is a neurodegenerative disease which significantly increases with age.Its onset can be either early or late.AD is characterized by the salient inflammatory features, microglial activation, and increased levels of proinflammatory cytokines which contribute to the inflammatory status of the central nervous system (CNS).

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, Satara, India.

ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease which significantly increases with age. Its onset can be either early or late. AD is characterized by the salient inflammatory features, microglial activation, and increased levels of proinflammatory cytokines which contribute to the inflammatory status of the central nervous system (CNS). Whereas, periodontitis is a common oral infection associated with the gram negative anaerobic bacteria. Periodontitis can be marked as a "low-grade systemic disease" by release of proinflammatory cytokines into systemic circulation and elevation of C-reactive protein (CRP). Inflammation is known to play a pivotal role in both the disease process serving as a connecting link between periodontitis and AD. The present review throws a light on possible enigmatic link between AD and periodontitis. This review is designed by collecting data from PubMed database using key words like "Alzheimer's disease", "inflammation", "periodontitis", and "proinflammatory cytokines".

No MeSH data available.


Related in: MedlinePlus