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Association between Periodontitis and Alzheimer's Disease.

Abbayya K, Puthanakar NY, Naduwinmani S, Chidambar YS - N Am J Med Sci (2015)

Bottom Line: Alzheimer's disease (AD) is a neurodegenerative disease which significantly increases with age.Its onset can be either early or late.AD is characterized by the salient inflammatory features, microglial activation, and increased levels of proinflammatory cytokines which contribute to the inflammatory status of the central nervous system (CNS).

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, Satara, India.

ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease which significantly increases with age. Its onset can be either early or late. AD is characterized by the salient inflammatory features, microglial activation, and increased levels of proinflammatory cytokines which contribute to the inflammatory status of the central nervous system (CNS). Whereas, periodontitis is a common oral infection associated with the gram negative anaerobic bacteria. Periodontitis can be marked as a "low-grade systemic disease" by release of proinflammatory cytokines into systemic circulation and elevation of C-reactive protein (CRP). Inflammation is known to play a pivotal role in both the disease process serving as a connecting link between periodontitis and AD. The present review throws a light on possible enigmatic link between AD and periodontitis. This review is designed by collecting data from PubMed database using key words like "Alzheimer's disease", "inflammation", "periodontitis", and "proinflammatory cytokines".

No MeSH data available.


Related in: MedlinePlus

Pathogenesis of periodontitis
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Figure 1: Pathogenesis of periodontitis

Mentions: Periodontitis is basically a result of inflammation caused due to wide array of pathogenic microorganisms [Figure 1]. These microorganisms release numerous proteolytic enzymes, resulting in destruction of soft and hard tissues supporting the teeth. Release of LPSs from the gram negative bacteria results in the expression of proinflammatory factors/cytokines like IL-1α and -1β, IL-6, TNF-α, prostanoids, MMP, and by the host tissue cells (neutrophils and monocytes); ultimately paving way to more destruction of periodontal tissues. Hence, host response plays a role of diabolical “dual role” leading to self-destruction, due to the exaggerated expression of tissue proteolytic enzymes.[36]


Association between Periodontitis and Alzheimer's Disease.

Abbayya K, Puthanakar NY, Naduwinmani S, Chidambar YS - N Am J Med Sci (2015)

Pathogenesis of periodontitis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488989&req=5

Figure 1: Pathogenesis of periodontitis
Mentions: Periodontitis is basically a result of inflammation caused due to wide array of pathogenic microorganisms [Figure 1]. These microorganisms release numerous proteolytic enzymes, resulting in destruction of soft and hard tissues supporting the teeth. Release of LPSs from the gram negative bacteria results in the expression of proinflammatory factors/cytokines like IL-1α and -1β, IL-6, TNF-α, prostanoids, MMP, and by the host tissue cells (neutrophils and monocytes); ultimately paving way to more destruction of periodontal tissues. Hence, host response plays a role of diabolical “dual role” leading to self-destruction, due to the exaggerated expression of tissue proteolytic enzymes.[36]

Bottom Line: Alzheimer's disease (AD) is a neurodegenerative disease which significantly increases with age.Its onset can be either early or late.AD is characterized by the salient inflammatory features, microglial activation, and increased levels of proinflammatory cytokines which contribute to the inflammatory status of the central nervous system (CNS).

View Article: PubMed Central - PubMed

Affiliation: Department of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, Satara, India.

ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease which significantly increases with age. Its onset can be either early or late. AD is characterized by the salient inflammatory features, microglial activation, and increased levels of proinflammatory cytokines which contribute to the inflammatory status of the central nervous system (CNS). Whereas, periodontitis is a common oral infection associated with the gram negative anaerobic bacteria. Periodontitis can be marked as a "low-grade systemic disease" by release of proinflammatory cytokines into systemic circulation and elevation of C-reactive protein (CRP). Inflammation is known to play a pivotal role in both the disease process serving as a connecting link between periodontitis and AD. The present review throws a light on possible enigmatic link between AD and periodontitis. This review is designed by collecting data from PubMed database using key words like "Alzheimer's disease", "inflammation", "periodontitis", and "proinflammatory cytokines".

No MeSH data available.


Related in: MedlinePlus