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Trans-arterial chemoembolization and external beam radiation therapy for treatment of hepatocellular carcinoma with a tumor thrombus in the inferior vena cava and right atrium.

Duan F, Yu W, Wang Y, Liu FY, Song P, Wang ZJ, Yan JY, Yuan K, Wang MQ - Cancer Imaging (2015)

Bottom Line: All treatments were successful and without significant complications.No severe adverse effects were observed.One patient was monitored for 97 months and no recurrence was observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Interventional Radiology, the General Hospital of Chinese People's Liberation Army, Beijing, 100853, China. duanfeng@vip.sina.com.

ABSTRACT

Background: Hepatocellular carcinoma (HCC) with a tumor thrombus in the inferior vena cava (IVC) and right atrium (RA) rarely occurs and is usually associated with extremely poor prognosis, we carried out this study to evaluate the efficacy and safety of a combination of trans-arterial chemoembolization (TACE) and external beam radiation therapy (EBRT) in the treatment of HCC with a tumor thrombus in the IVC and RA.

Methods: From September 2005 to September 2008, 11 cases of HCC with a tumor thrombus in the IVC and RA were treated with a combination of TACE and EBRT. Clinical adverse events, laboratory toxicity, and survival were retrospectively studied.

Results: Thirty-one interventional procedures were conducted and EBRT was performed 11 times. All treatments were successful and without significant complications. No severe adverse effects were observed. The median survival time of the 11 cases was 21.0 months. One patient was monitored for 97 months and no recurrence was observed.

Conclusion: The combination of TACE and EBRT can be safely performed and may improve the prognosis of the HCC cases with a tumor thrombus in the IVC and RA.

No MeSH data available.


Related in: MedlinePlus

Enhanced CT arterial phase of a 30-year-old female showed filling-defect in IVC/RA (→)
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Fig4: Enhanced CT arterial phase of a 30-year-old female showed filling-defect in IVC/RA (→)

Mentions: In the present study, a tumor thrombus in IVC and RA was distinct from a portal vein tumor thrombus in that it has a defined arterial blood supply, which included the hepatic artery (5/11) and inferior phrenic artery (IPA) (6/11). During the TACE procedure, we delivered lipiodol-chemotherapeutic agents to the tumor thrombus via a microcatheter, and follow-up images showed lipiodol deposition (Figs. 2, 3, 4 and 5).Fig. 2


Trans-arterial chemoembolization and external beam radiation therapy for treatment of hepatocellular carcinoma with a tumor thrombus in the inferior vena cava and right atrium.

Duan F, Yu W, Wang Y, Liu FY, Song P, Wang ZJ, Yan JY, Yuan K, Wang MQ - Cancer Imaging (2015)

Enhanced CT arterial phase of a 30-year-old female showed filling-defect in IVC/RA (→)
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4488985&req=5

Fig4: Enhanced CT arterial phase of a 30-year-old female showed filling-defect in IVC/RA (→)
Mentions: In the present study, a tumor thrombus in IVC and RA was distinct from a portal vein tumor thrombus in that it has a defined arterial blood supply, which included the hepatic artery (5/11) and inferior phrenic artery (IPA) (6/11). During the TACE procedure, we delivered lipiodol-chemotherapeutic agents to the tumor thrombus via a microcatheter, and follow-up images showed lipiodol deposition (Figs. 2, 3, 4 and 5).Fig. 2

Bottom Line: All treatments were successful and without significant complications.No severe adverse effects were observed.One patient was monitored for 97 months and no recurrence was observed.

View Article: PubMed Central - PubMed

Affiliation: Department of Interventional Radiology, the General Hospital of Chinese People's Liberation Army, Beijing, 100853, China. duanfeng@vip.sina.com.

ABSTRACT

Background: Hepatocellular carcinoma (HCC) with a tumor thrombus in the inferior vena cava (IVC) and right atrium (RA) rarely occurs and is usually associated with extremely poor prognosis, we carried out this study to evaluate the efficacy and safety of a combination of trans-arterial chemoembolization (TACE) and external beam radiation therapy (EBRT) in the treatment of HCC with a tumor thrombus in the IVC and RA.

Methods: From September 2005 to September 2008, 11 cases of HCC with a tumor thrombus in the IVC and RA were treated with a combination of TACE and EBRT. Clinical adverse events, laboratory toxicity, and survival were retrospectively studied.

Results: Thirty-one interventional procedures were conducted and EBRT was performed 11 times. All treatments were successful and without significant complications. No severe adverse effects were observed. The median survival time of the 11 cases was 21.0 months. One patient was monitored for 97 months and no recurrence was observed.

Conclusion: The combination of TACE and EBRT can be safely performed and may improve the prognosis of the HCC cases with a tumor thrombus in the IVC and RA.

No MeSH data available.


Related in: MedlinePlus