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Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients--a randomized controlled trial.

Carvalho RF, Huguenin GV, Luiz RR, Moreira AS, Oliveira GM, Rosa G - Nutr J (2015)

Bottom Line: The placebo group showed a reduction in FT3 levels (-0.1 ± 0.4, P = 0.03) and increased Lp(a) levels (5.9 ± 18.0 mg/dL, P = 0.02).There were no statistical differences in blood pressure and serum lipids between Brazil nut and placebo group.Supplementation with Brazil nuts seems to favor the maintenance of FT3 levels and contributes to lipemia reduction in hypercholesterolemic and euthyroid patients.

View Article: PubMed Central - PubMed

Affiliation: Post Graduate Program, Federal Universityof Rio de Janeiro, Professor Rodolpho Paulo Rocco St, 225, Rio de Janeiro, Brazil. beta_franca_carvalho@yahoo.com.br.

ABSTRACT

Objective: Thyroid hormones can lower levels of atherogenic lipoproteins, and selenium is important in thyroid hormone homeostasis. We aimed to investigate the effects of a healthy diet associated with the Brazil nut (Bertholletia excelsa) in dyslipidemic and hypertensive patients.

Methods: This study was a randomized, placebo-controlled, double-blind trial. Seventy-seven dyslipidemic and hypertensive patients already receiving lipid-lowering drugs received either a dietary treatment associated with partially defatted Brazil nut flour (13 g/day providing 227,5 μg of selenium/day),or with dyed cassava flour as a placebo. All patients received a personalized dietary guideline with nutritional recommendations for dyslipidemia and hypertension and were followed for 90 days.

Results: The Brazil nut group showed reductions in total cholesterol (-20.5 ± 61.2 mg/dL, P = 0.02), non HDL-cholesterol (-19.5 ± 61.2 mg/dL, P = 0.02) and Apo A-1 (-10.2 ± 26.7 mg/dL, P = 0.03) without significant alterations in the Apo B/Apo A-1 ratio. The placebo group showed a reduction in FT3 levels (-0.1 ± 0.4, P = 0.03) and increased Lp(a) levels (5.9 ± 18.0 mg/dL, P = 0.02). There were no statistical differences in blood pressure and serum lipids between Brazil nut and placebo group.

Conclusions: Supplementation with Brazil nuts seems to favor the maintenance of FT3 levels and contributes to lipemia reduction in hypercholesterolemic and euthyroid patients.

Trial registration: ClinicalTrials.gov Identifier NCT01990391.

No MeSH data available.


Related in: MedlinePlus

Serum total cholesterol levels in both groups over 90 days. Values are expressed as means and standard deviations with 95 % CI, n = 77. Values were measured for both groups on days 0, 30, 60 and 90. Values differed significantly only for the Brazil nut group at the T90
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Fig3: Serum total cholesterol levels in both groups over 90 days. Values are expressed as means and standard deviations with 95 % CI, n = 77. Values were measured for both groups on days 0, 30, 60 and 90. Values differed significantly only for the Brazil nut group at the T90

Mentions: Serum lipoprotein levels are presented in Table 4. There were no significant differences within or between groups in LDL-c, HDL-c, triglycerides, Apo B and the Apo B / Apo A-1 ratio during the study. After 90 days, total cholesterol (P = 0.02), non-HDL cholesterol (P = 0.02) and Apo A-1 (P = 0.03) decreased significantly only in the Brazil nut group, however there was no difference between groups. The placebo group presented an increase in Lp(a) levels (P = 0.02). Figure 3 presents the changes in total cholesterol between groups during the study.Fig. 3


Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients--a randomized controlled trial.

Carvalho RF, Huguenin GV, Luiz RR, Moreira AS, Oliveira GM, Rosa G - Nutr J (2015)

Serum total cholesterol levels in both groups over 90 days. Values are expressed as means and standard deviations with 95 % CI, n = 77. Values were measured for both groups on days 0, 30, 60 and 90. Values differed significantly only for the Brazil nut group at the T90
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4488974&req=5

Fig3: Serum total cholesterol levels in both groups over 90 days. Values are expressed as means and standard deviations with 95 % CI, n = 77. Values were measured for both groups on days 0, 30, 60 and 90. Values differed significantly only for the Brazil nut group at the T90
Mentions: Serum lipoprotein levels are presented in Table 4. There were no significant differences within or between groups in LDL-c, HDL-c, triglycerides, Apo B and the Apo B / Apo A-1 ratio during the study. After 90 days, total cholesterol (P = 0.02), non-HDL cholesterol (P = 0.02) and Apo A-1 (P = 0.03) decreased significantly only in the Brazil nut group, however there was no difference between groups. The placebo group presented an increase in Lp(a) levels (P = 0.02). Figure 3 presents the changes in total cholesterol between groups during the study.Fig. 3

Bottom Line: The placebo group showed a reduction in FT3 levels (-0.1 ± 0.4, P = 0.03) and increased Lp(a) levels (5.9 ± 18.0 mg/dL, P = 0.02).There were no statistical differences in blood pressure and serum lipids between Brazil nut and placebo group.Supplementation with Brazil nuts seems to favor the maintenance of FT3 levels and contributes to lipemia reduction in hypercholesterolemic and euthyroid patients.

View Article: PubMed Central - PubMed

Affiliation: Post Graduate Program, Federal Universityof Rio de Janeiro, Professor Rodolpho Paulo Rocco St, 225, Rio de Janeiro, Brazil. beta_franca_carvalho@yahoo.com.br.

ABSTRACT

Objective: Thyroid hormones can lower levels of atherogenic lipoproteins, and selenium is important in thyroid hormone homeostasis. We aimed to investigate the effects of a healthy diet associated with the Brazil nut (Bertholletia excelsa) in dyslipidemic and hypertensive patients.

Methods: This study was a randomized, placebo-controlled, double-blind trial. Seventy-seven dyslipidemic and hypertensive patients already receiving lipid-lowering drugs received either a dietary treatment associated with partially defatted Brazil nut flour (13 g/day providing 227,5 μg of selenium/day),or with dyed cassava flour as a placebo. All patients received a personalized dietary guideline with nutritional recommendations for dyslipidemia and hypertension and were followed for 90 days.

Results: The Brazil nut group showed reductions in total cholesterol (-20.5 ± 61.2 mg/dL, P = 0.02), non HDL-cholesterol (-19.5 ± 61.2 mg/dL, P = 0.02) and Apo A-1 (-10.2 ± 26.7 mg/dL, P = 0.03) without significant alterations in the Apo B/Apo A-1 ratio. The placebo group showed a reduction in FT3 levels (-0.1 ± 0.4, P = 0.03) and increased Lp(a) levels (5.9 ± 18.0 mg/dL, P = 0.02). There were no statistical differences in blood pressure and serum lipids between Brazil nut and placebo group.

Conclusions: Supplementation with Brazil nuts seems to favor the maintenance of FT3 levels and contributes to lipemia reduction in hypercholesterolemic and euthyroid patients.

Trial registration: ClinicalTrials.gov Identifier NCT01990391.

No MeSH data available.


Related in: MedlinePlus