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Terra incognita-cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia.

Tan RH, Devenney E, Kiernan MC, Halliday GM, Hodges JR, Hornberger M - Front Aging Neurosci (2015)

Bottom Line: Our results demonstrate a relationship between cognitive and neuropsychiatric decline across various domains of memory, language, emotion, executive, visuospatial function, and motivation and the degree of gray matter degeneration in cerebellar lobules V-VII.Most notably, bilateral cerebellar lobule VII and the posterior vermis emerged as distinct for memory processes, the right cerebellar hemisphere underpinned emotion, and the posterior vermis was highlighted in language dysfunction in bvFTD.Overall, the present study underscores the significance of cortical-cerebellar networks associated with cognition and neuropsychiatric dysfunction in bvFTD.

View Article: PubMed Central - PubMed

Affiliation: Ageing and Neurodegeneration, Neuroscience Research Australia Randwick, NSW, Australia ; School of Medical Sciences, University of New South Wales Sydney, NSW, Australia.

ABSTRACT
Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive and neuropsychiatric deficits. The present study assessed whether degeneration in specific cerebellar subregions associate with indices of cognition and neuropsychiatric performance in bvFTD. Our results demonstrate a relationship between cognitive and neuropsychiatric decline across various domains of memory, language, emotion, executive, visuospatial function, and motivation and the degree of gray matter degeneration in cerebellar lobules V-VII. Most notably, bilateral cerebellar lobule VII and the posterior vermis emerged as distinct for memory processes, the right cerebellar hemisphere underpinned emotion, and the posterior vermis was highlighted in language dysfunction in bvFTD. Based on cortico-cerebellar connectivity maps, these findings in the cerebellum are consistent with the neural connections with the cortices involved in these domains in patients with bvFTD. Overall, the present study underscores the significance of cortical-cerebellar networks associated with cognition and neuropsychiatric dysfunction in bvFTD.

No MeSH data available.


Related in: MedlinePlus

Voxel-based morphometry analyses showing cerebellar regions in which gray matter intensity correlates significantly with memory, language, executive, emotion, visuospatial task performance, and motivation measures across all participant groups. Colored voxels show regions that were significant in the analyses for p < 0.01 uncorrected and a cluster threshold of 20 contiguous voxels. All clusters reported t > 3.5. Clusters are overlaid on the MNI standard brain with a mask for lobule VII (crus 1, 2, and VIIb) shown in blue and a mask for the vermis shown in light blue. L, Left Hemisphere; R, Right Hemisphere.
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Figure 1: Voxel-based morphometry analyses showing cerebellar regions in which gray matter intensity correlates significantly with memory, language, executive, emotion, visuospatial task performance, and motivation measures across all participant groups. Colored voxels show regions that were significant in the analyses for p < 0.01 uncorrected and a cluster threshold of 20 contiguous voxels. All clusters reported t > 3.5. Clusters are overlaid on the MNI standard brain with a mask for lobule VII (crus 1, 2, and VIIb) shown in blue and a mask for the vermis shown in light blue. L, Left Hemisphere; R, Right Hemisphere.

Mentions: As can be seen in Figure 1 and Table 2, correlations between cerebellar gray matter atrophy with cognitive and neuropsychiatric measures were examined across all groups. Memory scores (brown color, Figure 1 and Table 2) correlated significantly with gray matter volumes in the posterior lobules VI–VIIB and vermis, with mild involvement identified in anterior lobules I–V. Composite scores of language (blue color, Figure 1 and Table 2) correlated significantly with gray matter volumes in the posterior lobule VI, left lobule VII (Crus I) and the vermis, with mild involvement also seen in lobule V. Executive measures (pink color, Figure 1 and Table 2) were found to associate with gray matter volumes in the posterior lobule VI and VII (Crus 1), with a mild association seen in lobule V. Emotion scores (green color, Figure 1 and Table 2) correlated with gray matter atrophy in the posterior lobule VI and Crus I. Visuospatial measures (red color, Figure 1 and Table 2) correlated with gray matter volume in the left cerebellar lobule VI. Patients' performance on tasks of motivation (red-yellow color, Figure 1 and Table 2) showed a significant association with gray matter volume in right-lateralized lobule VI. No significant correlations were identified between cerebellar volumes with neuropsychiatric measures of abnormal behavior, motivation, stereotypic behavior, mood, eating habits, and beliefs.


Terra incognita-cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia.

Tan RH, Devenney E, Kiernan MC, Halliday GM, Hodges JR, Hornberger M - Front Aging Neurosci (2015)

Voxel-based morphometry analyses showing cerebellar regions in which gray matter intensity correlates significantly with memory, language, executive, emotion, visuospatial task performance, and motivation measures across all participant groups. Colored voxels show regions that were significant in the analyses for p < 0.01 uncorrected and a cluster threshold of 20 contiguous voxels. All clusters reported t > 3.5. Clusters are overlaid on the MNI standard brain with a mask for lobule VII (crus 1, 2, and VIIb) shown in blue and a mask for the vermis shown in light blue. L, Left Hemisphere; R, Right Hemisphere.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488961&req=5

Figure 1: Voxel-based morphometry analyses showing cerebellar regions in which gray matter intensity correlates significantly with memory, language, executive, emotion, visuospatial task performance, and motivation measures across all participant groups. Colored voxels show regions that were significant in the analyses for p < 0.01 uncorrected and a cluster threshold of 20 contiguous voxels. All clusters reported t > 3.5. Clusters are overlaid on the MNI standard brain with a mask for lobule VII (crus 1, 2, and VIIb) shown in blue and a mask for the vermis shown in light blue. L, Left Hemisphere; R, Right Hemisphere.
Mentions: As can be seen in Figure 1 and Table 2, correlations between cerebellar gray matter atrophy with cognitive and neuropsychiatric measures were examined across all groups. Memory scores (brown color, Figure 1 and Table 2) correlated significantly with gray matter volumes in the posterior lobules VI–VIIB and vermis, with mild involvement identified in anterior lobules I–V. Composite scores of language (blue color, Figure 1 and Table 2) correlated significantly with gray matter volumes in the posterior lobule VI, left lobule VII (Crus I) and the vermis, with mild involvement also seen in lobule V. Executive measures (pink color, Figure 1 and Table 2) were found to associate with gray matter volumes in the posterior lobule VI and VII (Crus 1), with a mild association seen in lobule V. Emotion scores (green color, Figure 1 and Table 2) correlated with gray matter atrophy in the posterior lobule VI and Crus I. Visuospatial measures (red color, Figure 1 and Table 2) correlated with gray matter volume in the left cerebellar lobule VI. Patients' performance on tasks of motivation (red-yellow color, Figure 1 and Table 2) showed a significant association with gray matter volume in right-lateralized lobule VI. No significant correlations were identified between cerebellar volumes with neuropsychiatric measures of abnormal behavior, motivation, stereotypic behavior, mood, eating habits, and beliefs.

Bottom Line: Our results demonstrate a relationship between cognitive and neuropsychiatric decline across various domains of memory, language, emotion, executive, visuospatial function, and motivation and the degree of gray matter degeneration in cerebellar lobules V-VII.Most notably, bilateral cerebellar lobule VII and the posterior vermis emerged as distinct for memory processes, the right cerebellar hemisphere underpinned emotion, and the posterior vermis was highlighted in language dysfunction in bvFTD.Overall, the present study underscores the significance of cortical-cerebellar networks associated with cognition and neuropsychiatric dysfunction in bvFTD.

View Article: PubMed Central - PubMed

Affiliation: Ageing and Neurodegeneration, Neuroscience Research Australia Randwick, NSW, Australia ; School of Medical Sciences, University of New South Wales Sydney, NSW, Australia.

ABSTRACT
Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive and neuropsychiatric deficits. The present study assessed whether degeneration in specific cerebellar subregions associate with indices of cognition and neuropsychiatric performance in bvFTD. Our results demonstrate a relationship between cognitive and neuropsychiatric decline across various domains of memory, language, emotion, executive, visuospatial function, and motivation and the degree of gray matter degeneration in cerebellar lobules V-VII. Most notably, bilateral cerebellar lobule VII and the posterior vermis emerged as distinct for memory processes, the right cerebellar hemisphere underpinned emotion, and the posterior vermis was highlighted in language dysfunction in bvFTD. Based on cortico-cerebellar connectivity maps, these findings in the cerebellum are consistent with the neural connections with the cortices involved in these domains in patients with bvFTD. Overall, the present study underscores the significance of cortical-cerebellar networks associated with cognition and neuropsychiatric dysfunction in bvFTD.

No MeSH data available.


Related in: MedlinePlus