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Fetuin-A is related to infarct size, left ventricular function and remodelling after acute STEMI.

Feistritzer HJ, Klug G, Reinstadler SJ, Gröber MT, Mair J, Kirchmair R, Henninger B, Franz WM, Metzler B - Open Heart (2015)

Bottom Line: Fetuin-A levels (median 568 µg/mL, IQR 478-763 µg/mL) were significantly correlated with infarct size and LV ejection fraction at baseline and follow-up (all p<0.05).According to multivariate logistic regression analysis, fetuin-A concentrations (HR=0.17, 95% CI 0.03 to 0.89, p=0.036) besides the presence of late microvascular obstruction (HR=10.03, 95% CI 0.98 to 102.43, p=0.05) were significantly related to the occurrence of adverse LV remodelling at 4 months.In addition, it might be useful to identify patients at increased risk for adverse LV remodelling.

View Article: PubMed Central - PubMed

Affiliation: University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck , Innsbruck , Austria.

ABSTRACT

Objective: To investigate the relationship between plasma fetuin-A, an anti-inflammatory glycoprotein which might be involved in myocardial healing after acute infarction, and infarct size, left ventricular (LV) function and dimensions as well as the occurrence of adverse remodelling at 4 months after acute ST segment elevation myocardial infarction (STEMI).

Methods: In this single-centre prospective, observational study, 89 patients underwent cardiac MR within the first week and 4 months after mechanical reperfusion for first STEMI. Infarct size, LV function and dimensions were assessed at both time points. Fetuin-A levels were determined from blood samples drawn at a median of 49 h (IQR 30-59 h) after STEMI by an immunofluorescent assay.

Results: Fetuin-A levels (median 568 µg/mL, IQR 478-763 µg/mL) were significantly correlated with infarct size and LV ejection fraction at baseline and follow-up (all p<0.05). Moreover, fetuin-A was related to the increase in the end-diastolic volume index (r=-0.383, p<0.001). According to multivariate logistic regression analysis, fetuin-A concentrations (HR=0.17, 95% CI 0.03 to 0.89, p=0.036) besides the presence of late microvascular obstruction (HR=10.03, 95% CI 0.98 to 102.43, p=0.05) were significantly related to the occurrence of adverse LV remodelling at 4 months.

Conclusions: Circulating fetuin-A at day 2 after STEMI is related to acute and chronic infarct size, LV function and dimensions. In addition, it might be useful to identify patients at increased risk for adverse LV remodelling.

No MeSH data available.


Related in: MedlinePlus

Analysis of receiver operating characteristic of fetuin-A. The area under the curve of fetuin-A (0.68, 95% CI 0.56 to 0.80) with the optimal cut-off value of 544 µg/mL provided 71% sensitivity and 61% specificity for the prediction of adverse left ventricular remodelling at 4 months. The corresponding negative and positive predictive values were 92% and 26%.
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OPENHRT2015000244F3: Analysis of receiver operating characteristic of fetuin-A. The area under the curve of fetuin-A (0.68, 95% CI 0.56 to 0.80) with the optimal cut-off value of 544 µg/mL provided 71% sensitivity and 61% specificity for the prediction of adverse left ventricular remodelling at 4 months. The corresponding negative and positive predictive values were 92% and 26%.

Mentions: ROC curves indicating the risk for LV remodelling are shown in figures 3 and 4.


Fetuin-A is related to infarct size, left ventricular function and remodelling after acute STEMI.

Feistritzer HJ, Klug G, Reinstadler SJ, Gröber MT, Mair J, Kirchmair R, Henninger B, Franz WM, Metzler B - Open Heart (2015)

Analysis of receiver operating characteristic of fetuin-A. The area under the curve of fetuin-A (0.68, 95% CI 0.56 to 0.80) with the optimal cut-off value of 544 µg/mL provided 71% sensitivity and 61% specificity for the prediction of adverse left ventricular remodelling at 4 months. The corresponding negative and positive predictive values were 92% and 26%.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4488888&req=5

OPENHRT2015000244F3: Analysis of receiver operating characteristic of fetuin-A. The area under the curve of fetuin-A (0.68, 95% CI 0.56 to 0.80) with the optimal cut-off value of 544 µg/mL provided 71% sensitivity and 61% specificity for the prediction of adverse left ventricular remodelling at 4 months. The corresponding negative and positive predictive values were 92% and 26%.
Mentions: ROC curves indicating the risk for LV remodelling are shown in figures 3 and 4.

Bottom Line: Fetuin-A levels (median 568 µg/mL, IQR 478-763 µg/mL) were significantly correlated with infarct size and LV ejection fraction at baseline and follow-up (all p<0.05).According to multivariate logistic regression analysis, fetuin-A concentrations (HR=0.17, 95% CI 0.03 to 0.89, p=0.036) besides the presence of late microvascular obstruction (HR=10.03, 95% CI 0.98 to 102.43, p=0.05) were significantly related to the occurrence of adverse LV remodelling at 4 months.In addition, it might be useful to identify patients at increased risk for adverse LV remodelling.

View Article: PubMed Central - PubMed

Affiliation: University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck , Innsbruck , Austria.

ABSTRACT

Objective: To investigate the relationship between plasma fetuin-A, an anti-inflammatory glycoprotein which might be involved in myocardial healing after acute infarction, and infarct size, left ventricular (LV) function and dimensions as well as the occurrence of adverse remodelling at 4 months after acute ST segment elevation myocardial infarction (STEMI).

Methods: In this single-centre prospective, observational study, 89 patients underwent cardiac MR within the first week and 4 months after mechanical reperfusion for first STEMI. Infarct size, LV function and dimensions were assessed at both time points. Fetuin-A levels were determined from blood samples drawn at a median of 49 h (IQR 30-59 h) after STEMI by an immunofluorescent assay.

Results: Fetuin-A levels (median 568 µg/mL, IQR 478-763 µg/mL) were significantly correlated with infarct size and LV ejection fraction at baseline and follow-up (all p<0.05). Moreover, fetuin-A was related to the increase in the end-diastolic volume index (r=-0.383, p<0.001). According to multivariate logistic regression analysis, fetuin-A concentrations (HR=0.17, 95% CI 0.03 to 0.89, p=0.036) besides the presence of late microvascular obstruction (HR=10.03, 95% CI 0.98 to 102.43, p=0.05) were significantly related to the occurrence of adverse LV remodelling at 4 months.

Conclusions: Circulating fetuin-A at day 2 after STEMI is related to acute and chronic infarct size, LV function and dimensions. In addition, it might be useful to identify patients at increased risk for adverse LV remodelling.

No MeSH data available.


Related in: MedlinePlus